Eatwell for Cancer Prevention

Overseen By Meghan L Butryn, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Drexel University

Must not be taking: GLP-1 medications

Disqualifiers: Anorexia, Bulimia, Bariatric surgery, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how diet changes can help prevent cancer. Participants will either receive nutrition education or join the Eatwell program, which focuses on healthier grocery shopping and eating habits. The study seeks adults who do not currently follow dietary guidelines known to reduce cancer risk. Participants should be willing to attend sessions and have access to email and video calls. This trial may suit those looking to improve their eating habits to potentially lower their cancer risk.

As an unphased trial, this study offers a unique opportunity for participants to contribute to groundbreaking research on diet and cancer prevention.

Do I need to stop my current medications for the trial?

If you are currently taking medication that can significantly change your appetite or eating behavior, like a GLP-1 medication, you cannot participate in the trial. Otherwise, the protocol does not specify if you need to stop other medications.

What prior data suggests that the Eatwell intervention is safe for cancer prevention?

Research has shown that the Eatwell program helps people follow dietary guidelines that might reduce cancer risk. No specific safety concerns have been reported for this type of diet-focused program. It teaches individuals how to make healthier food choices, particularly when shopping for groceries or dining out.

As this trial does not involve testing a drug or medical device, the risks remain generally low. Participants learn to eat healthier, which is typically safe and well-tolerated. No known negative effects are linked to this type of dietary change. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Eatwell intervention because it offers a holistic approach to cancer prevention through dietary changes. Unlike standard cancer prevention strategies that might focus on supplements or pharmaceuticals, the Eatwell program emphasizes an inclusive lifestyle change involving the entire household. By educating both individuals and their families about nutrition, this approach aims to create a supportive environment that fosters long-term healthy eating habits, which could potentially reduce cancer risk more effectively than individual-focused interventions.

What evidence suggests that the Eatwell intervention could be effective for cancer prevention?

Research shows that diet can greatly affect the chances of developing cancer. Studies have found that healthier food choices can lower cancer risk. In this trial, participants in the Eatwell Condition will receive the Eatwell program, designed to improve grocery shopping habits, making it easier to buy healthy foods and avoid unhealthy ones. The idea is that having healthy food at home can support adherence to a diet that may prevent cancer. Although specific data on Eatwell's effectiveness for cancer prevention is limited, it follows dietary guidelines known to reduce cancer risk. ^{1 2 6 7 8}

Are You a Good Fit for This Trial?

The Eatwell Clinical Trial is for adults who don't usually follow dietary guidelines known to reduce cancer risk. Participants will be community members with low adherence to specific nutrition standards set by the WCRF/AICR, aiming to improve their diet.

Inclusion Criteria

Able and willing to visit a commercial laboratory partnered with this project (e.g., Labcorp) in order to have their blood drawn at the time of study visits

Access to technology necessary to receive emails and join videoconferencing meetings

Ability to read and speak English

Exclusion Criteria

Currently pregnant or planning to become pregnant in the next 18 months

Type 1 Diabetes

Planning to enroll in another lifestyle modification program in the next 18 months

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants are randomized to receive either the Eatwell intervention or traditional nutrition education

18 months

Regular assessments at 0, 6, and 18 months

Follow-up

Participants are monitored for changes in dietary adherence and biomarkers of inflammation

4-6 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Eatwell

Trial Overview This trial tests the effectiveness of the Eatwell intervention against standard nutrition education in helping participants make healthier food choices. It focuses on smarter grocery shopping, eating at home more often, and managing temptations when dining out.

How Is the Trial Designed?

Group I: Eatwell Condition Experimental Treatment 1 Intervention

Index participant and household members receive Eatwell intervention

Group II: Comparison Condition Active Control 1 Intervention

Index participants receive nutrition education sessions; household members receive no intervention contact

Who Is Running the Clinical Trial?

Drexel University

Lead Sponsor

Trials

160

Recruited

48,600+

National Institutes of Health (NIH)

Collaborator

Trials

2,896

Recruited

8,053,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT07225881

Study Details | NCT07225881 | Eatwell Clinical Trial (R01) The purpose of this study is to test an intervention that is designed to facilitate adherence to the dietary guidelines for cancer prevention ( ...

2. eatwellmealkits.com eatwellmealkits.com/impact-and-data/

Impact and Data - EatWell The EatWell Impact Report is an analytics-based executive summary of your populations' health. Focused insights on social determinants like food access.

3. prevention.cancer.gov prevention.cancer.gov/funding-and-grants/funded-grants/R01CA288323

Funded Grants | Division of Cancer Prevention In the Eatwell condition, grocery shopping will be the primary intervention target, with the goal of maximizing availability of healthy foods and limiting ...

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11298086/

The role of diet in cancer: the potential of shaping public policy ... Extensive research has demonstrated that diet plays a role in cancer pathogenesis at the genetic, epigenetic and cellular level.

5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10290234/

Nutrition as prevention for improved cancer health outcomes Only 30% to 50% of cancer patients at risk for malnutrition receive nutrition intervention (12,13). Considering that an estimated 1.9 million individuals were ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12243618/

Enhancing the utilization of healthy living interventions among ... The goal of this study was to identify opportunities to increase cancer survivor utilization of healthy eating and active living interventions aligned to cancer ...

7. cancer.org cancer.org/research/acs-research-news/new-nutrition-and-physical-activity-guidelines-for-cancer-survivors.html

For Your Best Life After Cancer—Eat Well & Be Physically ... Updated ACS guidelines for diet and physical activity aim to help cancer survivors reduce their risk for the cancer's return and for dying from cancer.

8. hsph.harvard.edu hsph.harvard.edu/research/nutrition-physical-activity/projects/

Projects | Prevention Research Center on Nutrition and ... This project addresses significant gaps in translating evidence-based healthful eating and physical activity interventions into practice and key health ...