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Moderate intensity continuous exercise (MICE) for Inflammation (AEX Trial)

N/A
Waitlist Available
Led By Jonathan P Little, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Body mass index between 18.5-30 kg/m^2
Free of cardiometabolic and autoimmune/inflammatory disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-exercise to immediately, 30-, and 90-min post-exercise
Awards & highlights

AEX Trial Summary

This trial shows exercise can reduce risk of chronic diseases by reducing chronic inflammation, measured by cytokines. Exercise intensity and pattern can affect the immune cell response, so understanding them helps know best exercises for health.

AEX Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Your body mass index (BMI) is within a normal range of 18.5 to 30 kg/m^2.
Select...
You do not have any heart, metabolism, autoimmune, or inflammatory problems.

AEX Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-exercise to immediately, 30-, and 90-min post-exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-exercise to immediately, 30-, and 90-min post-exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
IL-10 mediated STAT3 phosphorylation
Secondary outcome measures
Extracellular vesicles
Hematology panel
IL-10 mediated TNF-alpha inhibition
+5 more

AEX Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Moderate intensity continuous exercise (MICE)Experimental Treatment1 Intervention
Experimental session involving an acute bout of moderate intensity continuous exercise (MICE; continous cycling expending 350 kcal at 70% of lactate threshold)
Group II: High intensity interval exercise (HIIT)Experimental Treatment1 Intervention
Experimental session involving an acute bout of high intensity interval exercise (HIIT; cycling intervals expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)
Group III: High intensity continuous exercise (HICE)Experimental Treatment1 Intervention
Experimental session involving an acute bout of high intensity continuous exercise (HICE; continuous cycling expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)
Group IV: Resting (no exercise) controlPlacebo Group1 Intervention
Resting (no exercise) control condition

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,415 Previous Clinical Trials
2,467,000 Total Patients Enrolled
7 Trials studying Inflammation
1,435 Patients Enrolled for Inflammation
Jonathan P Little, PhDPrincipal InvestigatorUBC Okanagan
5 Previous Clinical Trials
267 Total Patients Enrolled
1 Trials studying Inflammation
20 Patients Enrolled for Inflammation

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study permit applicants aged fifty or more?

"According to the eligibility requirements for this clinical trial, participants must fall between 18-35 years of age."

Answered by AI

What is the sample size of this research endeavor?

"Absolutely. Data found on clinicaltrials.gov confirms that this study, which was initially posted on September 15th 2022, is currently recruiting patients. The trial requires 20 participants to be sourced from one medical centre."

Answered by AI

Am I eligible to take part in this medical research?

"This clinical experiment necessitates the recruitment of 20 individuals with inflammation, aged between 18 to 35. In addition, potential participants must have a body mass index ranging from 18.5-30 kg/m^2 and be free of cardiometabolic or autoimmune/inflammatory illnesses."

Answered by AI

Are there any vacancies for volunteers in this research investigation?

"As per the clinicaltrials.gov database, this medical trial is currently onboarding participants after being initially published on September 15th 2022 and recently updated on October 6th 2022."

Answered by AI

Who else is applying?

What site did they apply to?
UBC Okanagan
What portion of applicants met pre-screening criteria?
Did not meet criteria
~6 spots leftby Apr 2025