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Moderate intensity continuous exercise (MICE) for Inflammation (AEX Trial)

N/A
Waitlist Available
Led By Jonathan P Little, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-exercise to immediately, 30-, and 90-min post-exercise
Awards & highlights

Summary

This trial shows exercise can reduce risk of chronic diseases by reducing chronic inflammation, measured by cytokines. Exercise intensity and pattern can affect the immune cell response, so understanding them helps know best exercises for health.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-exercise to immediately, 30-, and 90-min post-exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-exercise to immediately, 30-, and 90-min post-exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
IL-10 mediated STAT3 phosphorylation
Secondary outcome measures
Extracellular vesicles
Hematology panel
IL-10 mediated TNF-alpha inhibition
+5 more

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Moderate intensity continuous exercise (MICE)Experimental Treatment1 Intervention
Experimental session involving an acute bout of moderate intensity continuous exercise (MICE; continous cycling expending 350 kcal at 70% of lactate threshold)
Group II: High intensity interval exercise (HIIT)Experimental Treatment1 Intervention
Experimental session involving an acute bout of high intensity interval exercise (HIIT; cycling intervals expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)
Group III: High intensity continuous exercise (HICE)Experimental Treatment1 Intervention
Experimental session involving an acute bout of high intensity continuous exercise (HICE; continuous cycling expending 350 kcal at 10% of the difference between lactate threshold and VO2peak)
Group IV: Resting (no exercise) controlPlacebo Group1 Intervention
Resting (no exercise) control condition

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Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,431 Previous Clinical Trials
2,478,887 Total Patients Enrolled
7 Trials studying Inflammation
1,435 Patients Enrolled for Inflammation
Jonathan P Little, PhDPrincipal InvestigatorUBC Okanagan
5 Previous Clinical Trials
267 Total Patients Enrolled
1 Trials studying Inflammation
20 Patients Enrolled for Inflammation
~6 spots leftby Jul 2025
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