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Peppermint Oil for Urinary Retention

Waitlist Available
Research Sponsored by TriHealth Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Experiencing urinary retention - defined as meeting at least one of the following criteria: More than 6 hours after delivery or foley catheter removal without being able to spontaneously void, Symptomatic urinary retention without being able to spontaneously void, Change in fundal height or position without being able to spontaneously void, Bladder scan showing bladder containing 400mL or more urine
18 years old or older
Must not have
Not able to void in toilet (ex: requiring use of bed pan to void)
Seizure disorder
Screening 3 weeks
Treatment Varies
Follow Up 10 minutes
Awards & highlights


This trial will study whether exposure to peppermint oil can help relieve urinary retention for postpartum women.

Who is the study for?
This trial is for English-speaking women over 18 who've recently given birth at Bethesda North Mom Baby Unit and are having trouble urinating on their own. They must be able to use the toilet normally, without a bedpan. Women with peppermint allergies, asthma, active herpes lesions, or seizure disorders cannot participate.Check my eligibility
What is being tested?
The study is testing if inhaling peppermint oil vapors helps postpartum women urinate more easily compared to inhaling mineral oil (placebo). Participants will be randomly assigned to one of these two treatments and monitored for how well they can pee without help and their satisfaction levels.See study design
What are the potential side effects?
Peppermint oil may cause minor side effects like a cooling sensation or tingling in the area where it's applied. In rare cases, it could lead to allergic reactions. Mineral oil is generally considered safe but might cause mild irritation when inhaled.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am unable to urinate on my own and have symptoms or tests confirming this.
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
I cannot use the toilet and need a bed pan.
I have a seizure disorder.
I have asthma.
I currently have active herpes sores.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percent of patients with urinary retention resolved
Secondary outcome measures
Incidence of urinary catheterization
Patient satisfaction
Time to spontaneous urination
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Peppermint OilExperimental Treatment1 Intervention
Subjects will be exposed to vapor of peppermint oil
Group II: PlaceboPlacebo Group1 Intervention
Subjects will be exposed to vapor of placebo (mineral oil)

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for urinary retention often focus on relaxing the muscles of the urinary tract to facilitate urination. For example, peppermint oil vapor is being studied for its aromatic properties, which may help relax the urinary tract muscles, thereby easing the passage of urine. Similarly, muscle relaxants and behavioral interventions like pelvic floor exercises aim to reduce muscle tension and improve bladder function. These mechanisms are crucial for urinary retention patients as they help alleviate the discomfort and potential complications associated with the inability to empty the bladder effectively.
Efficacy of Daily Intake of Dried Cranberry 500 mg in Women with Overactive Bladder: A Randomized, Double-Blind, Placebo Controlled Study.Phytotherapy in the treatment of benign prostatic hyperplasia.

Find a Location

Who is running the clinical trial?

TriHealth Inc.Lead Sponsor
98 Previous Clinical Trials
53,641 Total Patients Enrolled
3 Trials studying Urinary Retention
507 Patients Enrolled for Urinary Retention

Media Library

Mineral Oil Clinical Trial Eligibility Overview. Trial Name: NCT05259800 — N/A
Urinary Retention Research Study Groups: Placebo, Peppermint Oil
Urinary Retention Clinical Trial 2023: Mineral Oil Highlights & Side Effects. Trial Name: NCT05259800 — N/A
Mineral Oil 2023 Treatment Timeline for Medical Study. Trial Name: NCT05259800 — N/A
~35 spots leftby Jan 2026