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HD-tDCS for Depression

Q: Is this study looking for participants of a certain age or older?

The age range for inclusion into this medical experiment is 18 to 65. This trial has 193 qualifying cases for minors and 970 studies open to individuals aged over 65 years old.

Q: Are there still open slots available for participants in the trial?

Affirmative. According to the information published on clinicaltrials.gov, this medical trial has been actively recruiting since December 1st 2020 and is looking for up to 100 participants from a single site. The study was last updated on May 16th 2022.

Q: Is there any way to become involved in this experiment?

The requirements for enrollment in this medical trial are: a diagnosis of psychosis, involutional <a href="https://www.withpower.com/clinical-trials/depression">depression</a> and an age ranging from 18 to 65. The research team is hoping to accept 100 participants.

Q: What is the aggregate amount of individuals participating in this clinical experiment?

Affirmative. The details hosted on clinicaltrials.gov confirm that this medical study is actively seeking participants, having been posted on the first of December 2020 and last updated on the sixteenth of May 2022. It aims to recruit up to 100 people from one centre.

N/A

Waitlist Available

Led By Katherine L Narr, PhD

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Capacity to provide informed consent

Meet DSM-5 criteria for a moderate-to-severe MDE, with Hamilton Rating Scale for Depression (HAMD) score of ≥14 and <24

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 weeks

Awards & highlights

Study Summary

This trial will study the effects of high-definition transcranial direct current stimulation (HD-tDCS) compared to sham HD-tDCS in people with depression. HD-tDCS is a low-intensity neuromodulation technique that has been used to reduce depressive symptoms. The trial will last 12 sessions, each lasting 20 minutes, and will involve 100 people with depression.

Who is the study for?

This trial is for adults who can consent, live near UCLA, and have moderate-to-severe depression with specific scores on a depression scale. They must be treatment-naive or on stable antidepressants without changes for 6 weeks prior to the study. Participants should not make major hair changes during the study.Check my eligibility

What is being tested?

The trial tests High-Definition transcranial Direct Current Stimulation (HD-tDCS) against a sham procedure in reducing depressive symptoms over 12 sessions. It includes brain imaging to map current flow and track blood flow changes, along with clinical ratings and cognitive tests.See study design

What are the potential side effects?

tDCS may cause mild side effects like tingling, itching or discomfort at the electrode site, fatigue, headache, nausea or insomnia. Serious side effects are rare but could include mania in people with bipolar disorder.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I understand the details of the clinical trial and can consent to participate.

Select...

I have been diagnosed with moderate to severe depression.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Measured joint longitudinal change in rCBF and mood scores over the tDCS trial

Secondary outcome measures

Measured joint longitudinal change in regional brain activation and mood scores over the tDCS trial

Measured magnetic fields and rCBF at baseline and change in mood scores over the tDCS trial

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active - HD tDCSExperimental Treatment1 Intervention

Participants randomized to this arm will receive 12 sessions of high definition tDCS (HD-tDCS) stimulation (Soterix Medical) delivered to the left dorsolateral prefrontal cortex for 20-30 minutes.

Group II: Sham - HD tDCSPlacebo Group1 Intervention

Participants randomized to this arm will receive 12 sessions of sham HD tDCS stimulation (Soterix Medical) delivered to the left dorsolateral prefrontal cortex for 20-30 minutes.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Active - HD tDCS

2018

N/A

~70

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor

1,530 Previous Clinical Trials

10,264,615 Total Patients Enrolled

101 Trials studying Depression

48,371 Patients Enrolled for Depression

National Institutes of Health (NIH)NIH

2,698 Previous Clinical Trials

7,492,427 Total Patients Enrolled

54 Trials studying Depression

47,136 Patients Enrolled for Depression

National Institute of Mental Health (NIMH)NIH

2,785 Previous Clinical Trials

2,689,684 Total Patients Enrolled

666 Trials studying Depression

251,512 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this study looking for participants of a certain age or older?

"The age range for inclusion into this medical experiment is 18 to 65. This trial has 193 qualifying cases for minors and 970 studies open to individuals aged over 65 years old."

Answered by AI

Are there still open slots available for participants in the trial?

"Affirmative. According to the information published on clinicaltrials.gov, this medical trial has been actively recruiting since December 1st 2020 and is looking for up to 100 participants from a single site. The study was last updated on May 16th 2022."

Answered by AI

Is there any way to become involved in this experiment?

"The requirements for enrollment in this medical trial are: a diagnosis of psychosis, involutional depression and an age ranging from 18 to 65. The research team is hoping to accept 100 participants."

Answered by AI

What is the aggregate amount of individuals participating in this clinical experiment?

"Affirmative. The details hosted on clinicaltrials.gov confirm that this medical study is actively seeking participants, having been posted on the first of December 2020 and last updated on the sixteenth of May 2022. It aims to recruit up to 100 people from one centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression

Katherine Narr 2020. "Transcranial Direct Current Stimulation (tDCS) Therapy in Major Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04507243.

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