Repetitive Transcranial Magnetic Stimulation (rTMS) for Schizophrenia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
New York State Psychiatric Institute, New York, NYSchizophreniaRepetitive Transcranial Magnetic Stimulation (rTMS) - Device
Eligibility
22 - 55
All Sexes
What conditions do you have?
Select

Study Summary

This trial will use magnetic pulses to try and lessen symptoms of schizophrenia, specifically auditory hallucinations.

Eligible Conditions
  • Schizophrenia

Treatment Effectiveness

Study Objectives

2 Primary · 7 Secondary · Reporting Duration: Up to 4 weeks.

2 weeks
Change in Clinical Global Impression Improvement (CGI-I) Scale
Change in Clinical Global Impression Severity (CGI-S) Scale
2 weeks.
Total number of rTMS sessions completed
Total number of treatment emergent adverse events
Up to 4 weeks.
Change in Auditory Hallucination Rating Scale (AHRS)
Change in Cardiff Anomalous Perceptions Scale (CAPS)
Change in Positive and Negative Syndrome Scale (PANSS)
Change in Psychotic Symptom Rating Scale (PSYRATS)
Change in Scale for the Assessment of Positive Symptoms (SAPS)

Trial Safety

Trial Design

1 Treatment Group

Individualized magnetic resonance imaging (MRI) guided rTMS
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Repetitive Transcranial Magnetic Stimulation (rTMS) · No Placebo Group · N/A

Individualized magnetic resonance imaging (MRI) guided rTMS
Device
Experimental Group · 1 Intervention: Repetitive Transcranial Magnetic Stimulation (rTMS) · Intervention Types: Device
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation (rTMS)
2011
Completed Phase 2
~710

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to 4 weeks.

Who is running the clinical trial?

Columbia UniversityLead Sponsor
1,316 Previous Clinical Trials
1,623,971 Total Patients Enrolled
21 Trials studying Schizophrenia
1,945 Patients Enrolled for Schizophrenia
Michael Avissar, MD, PhDPrincipal InvestigatorNew York State Psychiatric Institute
1 Previous Clinical Trials
12 Total Patients Enrolled
1 Trials studying Schizophrenia
12 Patients Enrolled for Schizophrenia

Eligibility Criteria

Age 22 - 55 · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have normal hearing.
You have been diagnosed with schizophrenia or schizoaffective disorder according to the DSM-5.
You must be right-handed.

Who else is applying?

What state do they live in?
California100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
New York State Psychiatric Institute100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%

Frequently Asked Questions

How many participants are actively engaged in this research endeavor?

"Confirmed. According to the information available on clinicaltrials.gov, this medical experiment is actively enrolling participants since its initial posting on August 1st 2022 and last update of August 2nd 2022. A total of 12 patients are needed from a single location." - Anonymous Online Contributor

Unverified Answer

Does the recruitment for this research include individuals older than twenty?

"According to the specified inclusion criteria, only individuals aged between 22 and 55 can join this clinical trial. Those younger than 18 are limited to 47 studies while there is a greater assortment of options for those over 65 with 169 available." - Anonymous Online Contributor

Unverified Answer

Are there open slots to take part in the clinical research presently?

"Affirmative, the information found on clinicaltrials.gov shows that this study is currently recruiting participants. The trial was initially posted on August 1st 2022 and last updated a single day later, with 12 patients sought from one site." - Anonymous Online Contributor

Unverified Answer

What objectives is the research team looking to accomplish with this clinical trial?

"The principle objective of this experimental trial, to be assessed over a two-week period, is the total number of treatment emergent adverse events. Secondary objectives include gauging changes in Cardiff Anomalous Perceptions Scale (CAPS), Psychotic Symptom Rating Scale (PSYRATS) and Scale for the Assessment of Positive Symptoms (SAPS). CAPS scores range from 0-32 with higher numbers indicating more perceptual anomalies; PSYRATS consists of 17 items rated from none to severe on auditory hallucinations and delusions; SAPS includes 34 items that measure positive symptoms related to schizophrenia each given an intensity score between 0-5." - Anonymous Online Contributor

Unverified Answer

What are the ideal characteristics of a participant for this research effort?

"Candidates aged 22 to 55 with a schizophrenia diagnosis are eligible for this clinical trial. A ceiling of 12 participants exists for the experiment." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.