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Procedure

iCBT + TMS for Depression

N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to post-treatment (6 weeks), as well as 6-month and 9-month follow-up
Awards & highlights

Summary

This trial is researching if combining TMS (a brain stim approach) & internet-deliv. CBT (therapy) can help treat MDD (depression) better than TMS alone.

Who is the study for?
This trial is for individuals with Major Depressive Disorder (MDD) already undergoing Transcranial Magnetic Stimulation (TMS) at the UCLA TMS Clinic. It's not suitable for pregnant individuals, those currently in external CBT programs, people with substance dependence, certain comorbidities, metal implants, psychosis, autism spectrum disorders or complex regional pain syndromes.Check my eligibility
What is being tested?
The study is testing whether combining TMS with an internet-based Cognitive Behavioral Therapy (iCBT) and Psychoeducation provides better outcomes than TMS alone for treating MDD. The iCBT aims to enhance treatment without adding much burden on patients.See study design
What are the potential side effects?
While specific side effects are not listed here, typical ones from TMS may include headaches or discomfort at the stimulation site. Internet-based CBT usually does not have physical side effects but can sometimes cause emotional distress.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to post-treatment (6 weeks), as well as 6-month and 9-month follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to post-treatment (6 weeks), as well as 6-month and 9-month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Dimensional Anhedonia Rating Scale (DARS)
Hamilton Depression Rating Scale (HAM-D)
Inventory of Depressive Symptomatology (IDS)
+1 more
Secondary outcome measures
Generalized Anxiety Disorder (GAD-7)

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: iCBT and TMSActive Control2 Interventions
All participants complete six weeks of TMS treatment (five days per week) within the UCLA TMS Clinic. Participants in this condition additionally access iCBT materials and attend a weekly session for 30 minutes with a trained mental health coach to discuss iCBT content.
Group II: Psychoeducation and TMSPlacebo Group2 Interventions
All participants complete six weeks of TMS treatment (five days per week) within the UCLA TMS Clinic. Participants in this condition additionally access educational materials about mental health and attend a weekly session for 30 minutes with a trained mental health coach to discuss educational content.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Transcranial Magnetic Stimulation (TMS) and Cognitive-Behavioral Therapy (CBT) are two common treatments for depression that work through different mechanisms. TMS is a non-invasive brain stimulation technique that uses magnetic fields to modulate neural activity in brain regions associated with mood regulation, such as the prefrontal cortex. This can help alleviate depressive symptoms by enhancing neural connectivity and activity. CBT is a psychological intervention that aims to change negative thought patterns and behaviors by teaching patients coping skills and strategies to manage their symptoms. Combining TMS and CBT can be particularly effective because TMS can provide immediate neural changes, making the brain more receptive to the cognitive restructuring facilitated by CBT. This dual approach addresses both the biological and psychological aspects of depression, offering a more comprehensive treatment.

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,541 Previous Clinical Trials
10,267,003 Total Patients Enrolled
101 Trials studying Depression
48,403 Patients Enrolled for Depression

Media Library

Internet-Based Cognitive Behavioral Therapy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05988619 — N/A
Depression Research Study Groups: Psychoeducation and TMS, iCBT and TMS
Depression Clinical Trial 2023: Internet-Based Cognitive Behavioral Therapy Highlights & Side Effects. Trial Name: NCT05988619 — N/A
Internet-Based Cognitive Behavioral Therapy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05988619 — N/A
~9 spots leftby Jul 2025