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Cognitive Behavioral Therapy for Depression (CBT Trial)

N/A
Waitlist Available
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-treatment which is within 2 weeks after final therapy session (i.e. estimated 12-14 weeks after initial intake interview)
Awards & highlights

CBT Trial Summary

This trial is testing a new type of therapy, Adapted Cognitive-Behavior Therapy (ACBT), to see if it works better than the standard Cognitive Behavior Therapy (CBT) for women with depression and low literacy.

Who is the study for?
This trial is for English-speaking women over 18 with major depressive disorder who are willing to try different types of therapy and complete all study assessments. They must not plan to move from the Chicagoland area during the study, have no severe substance use disorders, suicidal actions in recent months, or significant neurological diseases.Check my eligibility
What is being tested?
The trial compares Adapted Cognitive-Behavior Therapy (ACBT), designed for those with low literacy, against standard Cognitive Behavior Therapy (CBT) to see which is more effective at improving outcomes for women suffering from depression.See study design
What are the potential side effects?
While CBT typically doesn't cause physical side effects, participants may experience emotional discomfort discussing personal issues. Some might feel anxious or upset temporarily after sessions.

CBT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-treatment which is within 2 weeks after final therapy session (i.e. estimated 12-14 weeks after initial intake interview)
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-treatment which is within 2 weeks after final therapy session (i.e. estimated 12-14 weeks after initial intake interview) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
PROMIS Depression: : 3-month follow-up (defined as 3 months after the last (i.e., 12th) session of cognitive behavior therapy.
PROMIS Depression: Post-treatment (defined as completing 12 therapy session)
Secondary outcome measures
World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0): 3-month follow-up (defined as 3 months after the end of treatment)
World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0): Post-treatment (defined as completing 12 sessions of therapy; this will occur an estimated 12-14 weeks after initial intake interview)
Other outcome measures
California Psychotherapy Alliance Scale - Participant version short-form - Post-treatment (defined as completing 12 sessions of therapy; this will occur an estimated 12-14 weeks after initial intake interview)
Patient Global Impression of Change (PGIC) 3-month follow-up (defined as 3 months after the end of treatment)
Patient Global Impression of Change (PGIC): Post-treatment (defined as completing 12 sessions of therapy; this will occur an estimated 12-14 weeks after initial intake interview)

CBT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Adapted CBTExperimental Treatment1 Intervention
Adapted CBT, 12 sessions each lasting 45 minutes
Group II: Standard CBTActive Control1 Intervention
Standard CBT, 12 sessions each lasting 45 minutes
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Adapted CBT
2020
N/A
~30

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Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,585 Previous Clinical Trials
917,209 Total Patients Enrolled
66 Trials studying Depression
28,403 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants have been accepted into this research project?

"Affirmative. According to information on clinicaltrials.gov, this medical experiment is actively seeking participants. It was first posted on February 14th 2020 and has most recently been updated June 16th 2022. The trial is looking for 40 individuals across 1 site in total."

Answered by AI

What is the overarching aim of this clinical experiment?

"This medical trial's principal aim, monitored over a 3-month period after the protocol concludes, is to assess treatment progress via Hamilton Depression Rating Scale (HAM-D). Secondary objectives are Structured Clinical Interview for DSM 5 (SCID-5) post-treatment outcomes and World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) presented in both at the end of therapy and following a 3 month follow up period; which will be used to quantify any changes made by intervention."

Answered by AI

Is this experiment accepting participants at present?

"As per the clinicaltrials.gov repository, this study is currently enrolling participants. The trial was first published on February 14th 2020 and modifications were last made to it on June 16th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
How old are they?
18 - 65
What site did they apply to?
James W. Griffith
What portion of applicants met pre-screening criteria?
Met criteria

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
Testing Different Modes of Cognitive Behavior Therapy
James W Griffith 2020. "Testing Different Modes of Cognitive Behavior Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04279028.
~4 spots leftby Apr 2025
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