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Neurostimulation

Brain Stimulation for Depression

N/A
Recruiting
Led By Michael Treadway, PhD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1, during tms/ ti stimulation
Awards & highlights

Study Summary

This trial will study how depression affects the ability to make decisions, by looking at how different regions of the brain impact difficult choices. TMS will be used on participants to study this.

Who is the study for?
This trial is for English-speaking adults with depression, who are not at high risk of suicide and have no history of substance abuse in the past year. Participants should not be using psychotropic medications or have conditions that could worsen with neurostimulation. Pregnant women and those with metal implants or a history of seizures are excluded.Check my eligibility
What is being tested?
The study examines how brain stimulation affects decision-making in people with depression. It involves game-like tasks performed while undergoing Transcranial Magnetic Stimulation (TMS) or Transcranial Indirect Stimulation (TI), focusing on the cingulate cortex's role in cognitive control during challenging choices.See study design
What are the potential side effects?
Potential side effects from TMS/TI may include discomfort at the stimulation site, headache, lightheadedness, or seizures (rare). There might also be temporary changes in thinking patterns or mood.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1, during tms/ ti stimulation
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1, during tms/ ti stimulation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Staggered Effort-Based Decision-Making Task

Trial Design

2Treatment groups
Active Control
Group I: Participants with Major Depressive Disorder (MDD)Active Control1 Intervention
Participants with MDD will complete computer tasks while receiving TMS/ TI
Group II: Healthy ControlActive Control1 Intervention
Participants without MDD will complete computer tasks while receiving TMS/TI

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,781 Previous Clinical Trials
2,674,778 Total Patients Enrolled
665 Trials studying Depression
251,234 Patients Enrolled for Depression
Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,560,373 Total Patients Enrolled
59 Trials studying Depression
8,816 Patients Enrolled for Depression
Michael Treadway, PhD4.5573 ReviewsPrincipal Investigator - Emory University
Emory University Hospital, Northside Hospital, Cartersville Medical Center, Northside Hospital - Forsyth
Harvard University, Beth Israel Deaconess Medical Center, Residency in Podiatric Surgery
2 Previous Clinical Trials
292 Total Patients Enrolled
1 Trials studying Depression
42 Patients Enrolled for Depression
5Patient Review
The doctor was very efficient in his work and I left feeling much better.

Media Library

TMS (Neurostimulation) Clinical Trial Eligibility Overview. Trial Name: NCT04099056 — N/A
Depression Research Study Groups: Participants with Major Depressive Disorder (MDD), Healthy Control
Depression Clinical Trial 2023: TMS Highlights & Side Effects. Trial Name: NCT04099056 — N/A
TMS (Neurostimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04099056 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research study permit young adults below the age of 30 to participate?

"This experiment seeks individuals who are within the age range of 18 to 65."

Answered by AI

Are there any recruitment openings for this research endeavor?

"Affirmative. Clinicaltrials.gov has confirmed that this clinical trial, first posted on November 11th 2019, is currently recruiting patients with a target of 200 participants across one site."

Answered by AI

How large is the participant pool of this experiment?

"Indeed, the current information posted on clinicaltrials.gov reveals that this experiment is actively seeking enrolment from participants. This trial first appeared online in November 2019 and has been updated as recently as September 2022; it seeks to recruit 200 volunteers from a single medical site."

Answered by AI

Could I be a participant in this research endeavor?

"To be considered for this research venture, individuals must have a diagnosis of depression and fall within the 18-65 age range. The team is looking to accept approximately 200 people into their study."

Answered by AI

Who else is applying?

What site did they apply to?
Emory University
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
2

Why did patients apply to this trial?

I am currently in need of a depression/anxiety clinical trial. I am currently taking Celexa 20mg. I have a long-history of depression and it runs in my family. I prefer phase 3 or above but open to a phase2 with previous studies or research already conducted.
PatientReceived 2+ prior treatments
~59 spots leftby Mar 2026