Hormone Therapy for Breast Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how hormone therapy affects breast cancer screening. It gathers data from breast imaging and examines the experiences and perceptions of individuals on hormone therapy undergoing screening. The trial also identifies barriers to effective breast cancer screening. Individuals who have been on hormone therapy for at least 9 months, have family members with breast cancer, and can communicate in English might be suitable participants. As an unphased trial, it provides a unique opportunity to contribute to understanding and improving breast cancer screening for those on hormone therapy.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. It focuses on individuals already on hormone therapy, so you may be able to continue your current treatment.
What prior data suggests that this breast cancer screening method is safe for individuals on hormone therapy?
Research has shown that hormone therapy can increase the risk of breast cancer, particularly for those with a history of the disease. This means that using hormone therapy raises the chance of breast cancer recurrence. However, cancers that develop in individuals using hormone therapy often grow more slowly and may be less aggressive. Careful consideration of these risks is important.
The safety of hormone therapy has been extensively studied. While it is used for various treatments, the risk of breast cancer remains a significant factor, especially for those with a previous diagnosis. Discussing these risks with a doctor is advisable to make an informed decision.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to improve breast cancer screening for individuals on hormone therapy by using a combination of standard mammography and whole breast ultrasound. Unlike traditional screening methods that might not account for the unique needs of those on hormone therapy, this approach gathers more comprehensive imaging data. Additionally, it seeks to enhance the screening process by understanding the experiences and perceptions of both patients and healthcare providers. This could lead to more personalized, equitable, and effective breast cancer screening protocols in the future.
What evidence suggests that hormone therapy is effective for breast cancer screening?
Research has shown that hormone therapy can affect breast cancer risk, highlighting the importance of regular screening. In this trial, individuals on hormone therapy will undergo breast imaging, including standard screening mammography and whole breast ultrasound. Studies have found that regular mammograms have led to a 28% reduction in breast cancer deaths among women aged 40 and older. Regular mammograms effectively detect breast cancer early. However, the benefits and potential downsides can vary based on factors such as age and breast density. People on hormone therapy should consider these factors when discussing screening options with their healthcare providers.24678
Who Is on the Research Team?
Chandler S Cortina, MD, MS
Principal Investigator
The Medical College of Wisconsin
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Breast Imaging and Data Collection
Participants undergo breast imaging, including standard screening mammography and whole breast ultrasound, and data is collected on gender-affirming therapy and family cancer history.
Qualitative Data Collection
Participants complete surveys and participate in interviews to gather qualitative data on their experiences and perceptions of breast cancer screening.
Follow-up
Participants are monitored for callback and biopsy rates after breast cancer screening.
What Are the Treatments Tested in This Trial?
Interventions
- Hormone Therapy
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Breast imaging data in the form of standard screening mammography in addition to screening whole breast ultrasound will be gathered and interpretations will follow the standard Breast Imaging Reporting and Data Systems. Insight on the perceptions and experiences of being involved in a breast cancer screening program will be gathered.
A semi-structure focus group to explore radiology faculty and staff experiences while capturing information on the perceived screening barriers, what support and/or training staff require to ensure patients are treated equitable in the screening process, and areas for providers and healthcare systems to improve breast cancer screening for individuals on hormone therapy.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor
Citations
Outcomes of Screening Mammography by Frequency, Breast ...
One study supporting our findings found that mammography every 3 to 4 years was cost-effective for women aged 50 to 79 years with fatty breasts and no other ...
Outcomes of Screening Mammography by Frequency ...
Objective To compare the benefits and harms of screening mammography frequencies according to age, breast density, and postmenopausal hormone ...
Effect of Three Decades of Screening Mammography on ...
Among women 40 years of age or older, deaths from breast cancer decreased from 71 to 51 deaths per 100,000 women — a 28% decrease. This ...
Breast Cancer Risk Assessment and Screening in Average ...
The review reported results from the Breast Cancer Surveillance Consortium that noted a 10-year, cumulative false-positive rate of 61% with annual screening and ...
5.
uspreventiveservicestaskforce.org
uspreventiveservicestaskforce.org/uspstf/recommendation/breast-cancer-screeningRecommendation: Breast Cancer: Screening
The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of supplemental screening for breast ...
Use of hormone therapy and risk of breast cancer detected ...
The population attributable fraction of breast cancer due to HT use was 19.8% overall. Ever users of HT tended to develop a cancer of lower grade. No other ...
HRT and Breast Cancer Risk Explained | BCRF
A 2021 review of systemic HRT in women with a history of breast cancer found that HRT significantly increased the risk of breast cancer recurrence, especially ...
Hormone Therapy and Breast Cancer Incidence Data
This aggregate dataset includes frequencies and adjusted quarterly rates of postmenopausal hormone therapy use and breast cancer.
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.