IMST for Chronic Kidney Disease and High Blood Pressure
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, you must be on a stable blood pressure medication regimen for at least 6 weeks before joining the study.
What data supports the effectiveness of the treatment IMST for Chronic Kidney Disease and High Blood Pressure?
Research shows that inspiratory muscle training (IMT) can improve respiratory muscle strength and functional capacity in patients with chronic kidney disease. Additionally, IMT has been found to have positive effects on high blood pressure, suggesting it may be a helpful treatment for these conditions.12345
Is inspiratory muscle strength training (IMST) safe for humans?
Research shows that high-resistance inspiratory muscle strength training (IMST) is safe and well-tolerated in adults, including those with high blood pressure. It has been used in various studies without significant safety concerns, making it a generally safe option for improving respiratory and cardiovascular health.13678
How is the treatment IMST different from other treatments for chronic kidney disease and high blood pressure?
IMST (Inspiratory Muscle Strength Training) is unique because it focuses on strengthening the muscles used for breathing, which can improve respiratory muscle strength and lung function. Unlike traditional treatments for high blood pressure and kidney disease, which often involve medication, IMST is a physical training method that can enhance breathing capacity and potentially improve quality of life.23489
What is the purpose of this trial?
More than 80% of individuals with chronic kidney disease have concomitant hypertension and the majority fail to achieve blood pressure control \<130/80 mmHg, leading to high risk of cardiovascular diseases and end-stage kidney disease. A stepwise combination of lifestyle modifications and drug therapy is recommended to lower blood pressure; however, adherence to time-intensive lifestyle interventions such as aerobic exercise in patients with chronic kidney disease is poor. This clinical trial seeks to establish the efficacy of high-resistance inspiratory muscle strength training, a novel time-efficient lifestyle intervention, for lowering systolic blood pressure and improving endothelial function in midlife and older adults with moderate-to-severe chronic kidney disease and inadequately controlled hypertension, and to use innovate translational assessments to understand the mechanisms involved.
Research Team
Michel B Chonchol, MD
Principal Investigator
University of Colorado, Denver
Kristen Nowak, PhD, MPH
Principal Investigator
University of Colorado, Denver
Eligibility Criteria
Adults over 50 with moderate-to-severe chronic kidney disease and high blood pressure that's not well-controlled, despite being on stable medication for at least 6 weeks. Participants should be non-smokers, not have had recent hospitalizations or severe heart failure, and cannot be using immunosuppressants or have significant lung diseases.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo inspiratory muscle strength training (IMST) or sham training for 3 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- IMST
- Sham Training
IMST is already approved in United States, European Union for the following indications:
- Chronic Kidney Disease
- Hypertension
- Chronic Kidney Disease
- Respiratory Muscle Weakness
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
University of Colorado, Boulder
Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator