CLINICAL TRIAL

Weight loss and aerobic exercise training for Inflammation

Waitlist Available · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether a weight loss and exercise intervention can reduce inflammation in people with overweight.

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About the trial for Inflammation

Eligible Conditions
Aging · Inflammation · Metabolism · Exercise

Treatment Groups

This trial involves 2 different treatments. Weight Loss And Aerobic Exercise Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Weight loss and aerobic exercise training
BEHAVIORAL
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
A stable medical regimen is one that has been taken for 30 days or more. show original
A person with a BMI of 20-40 kg/m2 is considered to be overweight. show original
The waist size for men is 80-120 cm, and for women it is 70-110 cm. show original
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 6 month
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 6 month.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Weight loss and aerobic exercise training will improve 1 primary outcome and 1 secondary outcome in patients with Inflammation. Measurement will happen over the course of 6 month.

Regional Adipokine Release
6 MONTH
Cardiovascular Fitness Body Composition Glucose Tolerance/Insulin Sensitivity
6 MONTH

Who is running the study

Principal Investigator
J. B.
Jacob Blumenthal, GRECC Investigator
University of Maryland, College Park

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get inflammation a year in the United States?

Each year, around 2.5 million US citizens are diagnosed with inflammation of the lungs. This puts them at a 13.2% risk of developing lung cancer. This risk is much higher for US African-Americans (21.5%) than for US Caucasians (7.4%).

Anonymous Patient Answer

What are the signs of inflammation?

Acute inflammation typically manifests with fever, chills and a rapid fall in blood pressure; pain and swelling of the joints; redness, warmth and diminished range of motion of joints; and tenderness. Chronic inflammation manifesting as a dull ache and/or general weakness can often be confused with depression and arthritis, which is why clinical physicians generally take a thorough history and medical examinations before pursuing further diagnosis.

Anonymous Patient Answer

Can inflammation be cured?

Given the role of inflammation in the development of depression and posttraumatic stress disorder, this study shows that it is potentially possible to treat inflammation with anti-inflammatory agents.

Anonymous Patient Answer

What causes inflammation?

Without a clear cause, the factors that are associated with some inflammatory diseases can help explain the processes that occur in others during periods of inflammation. The immune system may cause inflammation in response to signals from damaged cells, which may include viruses and bacteria, cell stress, or trauma. For example, the body's response to a virus may induce inflammation to prepare the body for the next infection. Alternatively, inflammation may be a desired and adaptive response to infection—either a primary immune response by cells that help to eliminate a pathogen, or a secondary, delayed response by tissue cells to help prepare the body for recovery.

Anonymous Patient Answer

What is inflammation?

Inflammatory responses are one of the predominant reactions in the host defense system and a very prominent feature in neuropathogeneses. Inflammatory-induced changes in host brain may affect brain pathogenesis directly, via neuroimmune interaction or neurogenic modulation, as well as indirectly, via neuroendocrine modulation, neurohumoral response and neurodegenerative changes. The latter may be especially important in neurodegenerative diseases, such as Alzheimer and Parkinson's disease. In fact, a significant body of evidence implicates proinflammatory changes in neurodegenerative conditions as a cause of disease, rather than a consequence of the disease.

Anonymous Patient Answer

What are common treatments for inflammation?

Findings from a recent study indicate that medications for Inflammation are common amongst patients treated by PEDs. Drugs for Inflammation are commonly used for a wide range of conditions from inflammatory bowel disease to noninfectious conditions such as rheumatoid arthritis. The type of medication prescribed was not a predictor for the use of anticoagulants. The types of treatment that were common to all patients were antibiotics for Noninfectious conditions and NSAIDS for Inflammation. However, we did observe that a smaller group of patients were prescribed DMARDs including corticosteroids. Patients who were prescribed DMARDs also had a lower rate of anticoagulation and these were the patients who had the shortest duration of prescription.

Anonymous Patient Answer

Has weight loss and aerobic exercise training proven to be more effective than a placebo?

Recent findings of this large-scale trial suggest that an exercise program of a moderate intensity is effective in improving weight and body composition, and suppressing inflammation and coagulation markers in patients with DM and DM2. These therapeutic factors were associated with changes in adipokine levels and pro-inflammatory markers, and to changes in pro-inflammatory markers in non-DM subjects.

Anonymous Patient Answer

Have there been any new discoveries for treating inflammation?

These clinical trials are ongoing, therefore we cannot draw clear conclusions. Some of the clinical trials were already completed; however, data is still accumulating. Some drugs showed positive results; for example, adalimumab (Humira) and adapalene gel show promising results in this subset of patients. Additional data from the ASCURE-1 trial, which includes data from patients with moderate to severe plaque psoriasis. ASCURE-1 is the first clinical and economic outcome study to prove the efficacy of adalimumab.

Anonymous Patient Answer

Is weight loss and aerobic exercise training typically used in combination with any other treatments?

Weight loss and aerobic exercise training are commonly used in conjunction with other treatments in the treatment of chronic pain disorders, but they are not used in conjunction with any other therapies.

Anonymous Patient Answer

What is the average age someone gets inflammation?

Inflammation may not first begin until someone is in their 20s; however, if it develops, it often has a slower growth rate than that of the average proliferation.

Anonymous Patient Answer

Is weight loss and aerobic exercise training safe for people?

Low-dose weight loss and exercise training are a safe strategy for weight management in overweight and obese patients and are associated with improved cardiometabolic outcomes.

Anonymous Patient Answer

Who should consider clinical trials for inflammation?

There is a shortage of clinicians and patients with inflammatory conditions and the current pace and complexity of clinical trials mean that clinicians are at risk of missing novel disease therapies. Clinical trials are well run and many trials are in the recruitment phase. Most clinical trials are run to demonstrate safety and efficacy of treatment. Many patients, clinicians and funders would consider clinical trials for inflammatory conditions to be a valuable option to help identify the best agent to treat disease even with limitations of the current standards of care. Clinicians and patients often have unmet expectations in their treatments and trials to enhance their care and satisfaction.

Anonymous Patient Answer
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