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Behavioural Intervention
Transmagnetic Stimulation for Primary Progressive Aphasia (TMS in PPA Trial)
N/A
Waitlist Available
Led By Michael H Rosenbloom, MD
Research Sponsored by HealthPartners Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Subjects are between 40-90 years of age
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights
TMS in PPA Trial Summary
This trial studies a non-invasive therapy for Frontotemporal Degeneration (FTD), a type of dementia, using brain scans and magnetic stimulation. The goal is to improve symptoms and support current treatment.
Who is the study for?
This trial is for individuals aged 40-90 with a confirmed diagnosis of nonfluent/agrammatic or semantic variant primary progressive aphasia. They must have had prior brain imaging and a Mini Mental Status Exam score over 10. Those with other types of dementia, seizure disorders, or who can't undergo fMRI due to implants/metal are excluded.Check my eligibility
What is being tested?
The study tests intermittent theta burst stimulation (iTBS), a non-invasive treatment using transcranial magnetic stimulation aimed at improving language functions in people with primary progressive aphasia by targeting specific brain regions.See study design
What are the potential side effects?
While the description doesn't list side effects, iTBS is generally considered safe but may cause discomfort at the stimulation site, headache, lightheadedness, or temporary hearing changes during the procedure.
TMS in PPA Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 40 and 90 years old.
TMS in PPA Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Connectivity measures of the left TGd, 55b, and STV parcellations at baseline and post-treatment
TMS in PPA Trial Design
1Treatment groups
Experimental Treatment
Group I: Intermittent theta burst stimulationExperimental Treatment1 Intervention
All subjects will receive treatment with intermittent theta burst stimulation (iTBS). There will be a total of 5 treatments over a 2-week period. All subjects will receive iTBS to the right TGd region. TBS treatment will also be provided for two additional sites within the large-scale brain networks (LSBNs) that is found to contain the greatest number of connectivity anomalies. Total participation will be 8-10 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Intermittent theta burst stimulation
2022
Completed Phase 2
~90
Find a Location
Who is running the clinical trial?
HealthPartners InstituteLead Sponsor
184 Previous Clinical Trials
3,716,156 Total Patients Enrolled
Michael H Rosenbloom, MDPrincipal InvestigatorHealthPartners Neurology
8 Previous Clinical Trials
281 Total Patients Enrolled
Kashyap Bhavani, PhD,MBBSPrincipal InvestigatorHealthPartners Neuroscience Research
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My condition is a type of dementia, but not FTD.You can't have a brain scan using rs-fMRI because you have metal implants that could be affected by the scan.I have a seizure disorder.I am between 40 and 90 years old.You are unable to tolerate resting-state functional magnetic resonance imaging (rs-fMRI).You have been diagnosed with a specific type of language disorder according to specific medical criteria.Your score on the Mini Mental Status Exam (MMSE) is higher than 10.
Research Study Groups:
This trial has the following groups:- Group 1: Intermittent theta burst stimulation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does the study extend eligibility to persons of 18 years or more?
"As outlined by the criteria to participate, those aged 40-90 are eligible for this experiment. Additionally, 10 trials will be conducted on patients younger than 18 and 130 with people over 65 years old."
Answered by AI
Who qualifies for enrollment in this clinical exploration?
"This trial is seeking participants with primary progressive aphasia, between 40 and 90 years of age. Currently, only 3 people have been recruited for the study."
Answered by AI
Is this research endeavor currently accepting participants?
"According to the official record on clinicaltrials.gov, this medical study is not actively recruiting at present. Initially posted in May of 2023 and last updated 5 days later, it has since concluded its search for patients; however there are still 133 other trials searching for individuals to participate in their research endeavour."
Answered by AI
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