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Diuretics for Chronic Kidney Failure (DIURESED Trial)

Phase 4

Waitlist Available

Led By Branko Braam, MD/Ph.D.

Research Sponsored by University of Alberta

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up week 5

Awards & highlights

DIURESED Trial Summary

This trial is studying if diuretics (water pills) can help dialysis patients preserve kidney function, increase urine output, and reduce weight gain. No guidelines exist for their use.

Who is the study for?

This trial is for adults over 18 who started hemodialysis within the last year, still produce a fair amount of urine, and are expected to live at least another 6 months. They must understand and sign consent. It's not for those allergic to the study drugs, unable to take pills by mouth, changing dialysis type soon, or with recent severe electrolyte problems.Check my eligibility

What is being tested?

The trial tests if diuretics like Chlorthalidone and Furosemide can help maintain kidney function in dialysis patients. It aims to see if these 'water pills' increase urine output and reduce weight gain between treatments since there's no current standard on using them in this situation.See study design

What are the potential side effects?

Diuretics may cause dehydration, low blood pressure, dizziness upon standing up quickly (orthostatic hypotension), electrolyte imbalances like low potassium or magnesium levels which could affect heart rhythm or muscle function.

DIURESED Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ week 5

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~week 5

This trial's timeline: 3 weeks for screening, Varies for treatment, and week 5 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in 24-hour urine output

Change in residual renal function

Secondary outcome measures

Adverse effects

Interdialytic weight gain

Patient-reported outcomes - ESAS-r

+2 more

DIURESED Trial Design

1Treatment groups

Experimental Treatment

Group I: Diuretic TherapyExperimental Treatment2 Interventions

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Chlorthalidone

2013

Completed Phase 4

~55260

Furosemide

2015

Completed Phase 4

~4240

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of AlbertaLead Sponsor

889 Previous Clinical Trials

385,104 Total Patients Enrolled

Branko Braam, MD/Ph.D.Principal InvestigatorUniversity of Alberta

Media Library

Diuretic Therapy Clinical Trial Eligibility Overview. Trial Name: NCT05915286 — Phase 4

Kidney Disease Research Study Groups: Diuretic Therapy

Kidney Disease Clinical Trial 2023: Diuretic Therapy Highlights & Side Effects. Trial Name: NCT05915286 — Phase 4

Diuretic Therapy 2023 Treatment Timeline for Medical Study. Trial Name: NCT05915286 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Diuretic Therapy a safe and effective treatment for individuals?

"Proper safety protocols have been verified through a Phase 4 trial, resulting in Diuretic Therapy receiving an appraisal of 3."

Answered by AI

Are they currently enrolling participants for this project?

"The study is currently gathering participants, based on information from clinicaltrials.gov, which notes that the trial was initially uploaded to their database on May 29th 2023 and recently updated June 13th of same year."

Answered by AI

What are the aims of this investigation?

"The principal measurement of efficacy in this investigation will take place around Week 5 and will be evaluating changes to residual renal function. Additional assessments include patient-reported outcomes using the Edmonton Symptom Assessment System-revised (ESAS-r) questionnaire, subjective reports on muscle cramps, and adverse effects as shown through symptoms and weekly bloodwork tests."

Answered by AI

How many participants are being accepted for this clinical trial?

"Affirmative. Per the information on clinicaltrials.gov, this health experiment is actively seeking out recruits; it was first posted on May 29th 2023 and last modified on June 13th 2023. The research needs 34 participants from one site to be completed successfully."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Diuretic Use in Hemodialysis Patients With Residual Renal Function

2023. "Diuretic Use in Hemodialysis Patients With Residual Renal Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05915286.