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Loop Diuretic

Torsemide vs Furosemide for Heart Failure (TFO Trial)

Phase 3
Waitlist Available
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Plan for a daily outpatient oral loop diuretic regimen with anticipated need for long term loop diuretic use
≥ 18 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year
Awards & highlights

TFO Trial Summary

This trial will compare two different loop diuretics to see which one is more effective in patients who are already taking a stable dose of loop diuretics.

Who is the study for?
This trial is for adults over 18 with stable heart failure who've been on a steady dose of diuretics for at least a month. It's not for pregnant or nursing women, those planning to conceive, patients with end-stage kidney disease on dialysis, heart transplant recipients or candidates, individuals with life-limiting conditions, or anyone allergic to the study drugs.Check my eligibility
What is being tested?
The trial aims to see which diuretic—Furosemide or Torsemide—is more effective in managing stable heart failure when taken orally as part of daily treatment. Participants will be randomly assigned one of these medications and monitored for outcomes.See study design
What are the potential side effects?
Possible side effects from Furosemide and Torsemide include dehydration, electrolyte imbalances (like low potassium), low blood pressure, dizziness upon standing up quickly, kidney issues and gastrointestinal problems such as nausea.

TFO Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am on a daily oral medication for swelling and expect to take it long-term.
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I am 18 years old or older.

TFO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
All-cause mortality, measured at 1 year.
Secondary outcome measures
All-cause hospitalization
Change in weight
Total hospitalizations

TFO Trial Design

2Treatment groups
Active Control
Group I: FurosemideActive Control1 Intervention
Furosemide, oral, dosage and frequency determined by treating physician or provider. 1 mg torsemide to 2-4 mg oral furosemide
Group II: TorsemideActive Control1 Intervention
Torsemide, oral, dosage and frequency determined by treating physician or provider. 1 mg torsemide to 2-4 mg oral furosemide

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,847 Previous Clinical Trials
2,736,403 Total Patients Enrolled
32 Trials studying Heart Failure
55,874 Patients Enrolled for Heart Failure

Media Library

Furosemide (Loop Diuretic) Clinical Trial Eligibility Overview. Trial Name: NCT05093621 — Phase 3
Heart Failure Research Study Groups: Furosemide, Torsemide
Heart Failure Clinical Trial 2023: Furosemide Highlights & Side Effects. Trial Name: NCT05093621 — Phase 3
Furosemide (Loop Diuretic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05093621 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has Furosemide been cleared by the FDA?

"Furosemide was given a score of 3, which means that while it is still in Phase 3 trials, there is some evidence to support both its efficacy and safety."

Answered by AI

Are there other precedents for using Furosemide in a medical setting?

"At present, there are 16 trials studying Furosemide. Of these active studies, 6 are in Phase 3. The majority of research for this medication is conducted in Dayton, Ohio; however, 44 different locations across the United States are running similar trials."

Answered by AI

Could you please share the total amount of individuals enrolled in this research?

"Unfortunately, this particular clinical trial is not presently recruiting candidates. This study was first posted on February 8th 2021 but has not been updated since September 14th of the same year. If you are looking for other studies, there are 735 trials actively admitting participants with heart failure and 16 trials for Furosemide that have open enrolment at this time."

Answered by AI

What treatments is Furosemide typically used in conjunction with?

"Furosemide is used to manage hypertension and can also help patients with chronic kidney disease, cirrhosis, and hypertensive disorders."

Answered by AI

Are there any current openings for enrolment in this experiment?

"Presently, this clinical trial is not enrolling patients. It was initially posted on February 8th 2021 but has not been updated since September 14th of the same year. For individuals searching for similar studies, there are 735 trials for heart failure and 16 furosemide trials that are still recruiting participants."

Answered by AI

Who else is applying?

What site did they apply to?
Yale University
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure
2021. "Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05093621.
All > Heart Failure
~30 spots leftby Apr 2025
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