Reviewed by Michael Gill, B. Sc.
Image of University of California Los Angeles Medical Center in Los Angeles, United States.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety

Antiarrhythmic Drugfor Cardiomyopathies

18+
All Sexes
Premature ventricular contractions (PVCs) coexist in patients with heart failure (HF) and LV dysfunction. Frequent PVCs have shown to induce a reversible cardiomyopathy (PVC-CM). This clinical pilot study will enroll 36 patients with frequent PVCs (burden >10%) and CM (LVEF <45%) and randomize them to either: 1) RFA or 2) AADs. Prior to treatment, patients will undergo a baseline cardiac MR if clinically indicated followed by 3-month observation period (optimal HF medical therapy). Changes in LV function/scar, PVC burden/arrhythmias and clinical/functional status (QOL, HF symptoms and admissions, NYHA class) and adverse events will be assessed throughout the observation period and compare with PVC suppression strategies (RFA or AAD). Similar comparison will be made between RFA and AAD treatment groups during a 12-month follow up using a Prospective Randomized Open, Blinded End-point (PROBE) study design. The treatment regimens will be compared in an intention-to-treat analysis. In addition, a total of 20,000 consecutive ambulatory ECG Holter monitors from all participating centers will be screened to identify all patients with probable diagnosis of PVC-CM. This pilot study is intended to estimate the prevalence of this clinical entity and pave the way for a large full scale randomized trial to identify best treatment strategy for patients with PVC-CM. Treating and reversing this underestimated PVC-CM may improve patient's health and subsequently decrease HF healthcare spending.
Phase 4
Waitlist Available
University of California Los Angeles Medical Center (+10 Sites)Jose F Huizar, M.D.
Image of University Health Network in Toronto, Canada.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety

CarnitineDeficientfor Carnitine Deficiency

18+
All Sexes
There are some adults with skeletal muscle weakness (called "myopathy") and heart muscle weakness (called "cardiomyopathy") who have low blood levels of a compound called carnitine as a cause of their problems. Carnitine is very important to energy production in muscles. In fact, there are reports of some people with carnitine deficiency who have developed myopathy and cardiomyopathy that was completely reversed with carnitine treatment. The main objective of our project is to determine the number of patients who have carnitine deficiency as a cause of their myopathy and cardiomyopathy. The investigators will be measuring carnitine levels in 1000 patients with cardiomyopathy and will describe the specific features in all the study patients to see if there are any trends that may help us predict which patients with muscle weakness are at risk of developing low carnitine levels. The investigators will be treating patients with low carnitine levels with carnitine and observing them to see if their cardiomyopathy and their muscle weakness improve. Knowing the exact percentage of myopathy and cardiomyopathy patients with carnitine deficiency may allow for screening of patients in a cheap and targeted way to treat the serious complication of this condition, including heart failure and sudden death.
Phase 4
Waitlist Available
University Health NetworkFaghfoury Hannaneh, MD
25 Cardiomyopathy Clinical Trials Near Me
Top Hospitals for Cardiomyopathy Clinical Trials
Image of Brigham and Women's Hospital in Massachusetts.
Brigham and Women's Hospital
Boston
8Active Trials
24All Time Trials for Cardiomyopathy
2006First Cardiomyopathy Trial
Image of Cedars-Sinai Medical Center in California.
Cedars-Sinai Medical Center
Los Angeles
5Active Trials
15All Time Trials for Cardiomyopathy
2007First Cardiomyopathy Trial
Top Cities for Cardiomyopathy Clinical Trials
Most Recent Cardiomyopathy Clinical Trials
Top Treatments for Cardiomyopathy Clinical Trials
Treatment Name
Active Cardiomyopathy Clinical Trials
All Time Trials for Cardiomyopathy
First Recorded Cardiomyopathy Trial
Carvedilol
2
5
2000
Pacing intervention
1
1
2022
AAVrh.10hFXN, serotype rh.10 adeno-associated virus (AAV) gene transfer vector expressing the cDNA coding for human FXN
1
1
2022
Bromocriptine Treatment Arm
1
1
2022
Intra-Op Prophylactic VT ablation
1
1
2022
Recently Completed Studies with FDA Approved Treatments for Cardiomyopathy
Treatment
Year
Sponsor
Standard of Care for Heart Failure
2016
M.D. Anderson Cancer Center

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 7th, 2021

Last Reviewed: October 4th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

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