← Back to Search

Loop Diuretic

Furosemide + Albumin for Liver Cirrhosis

Phase 4

Recruiting

Research Sponsored by Rush University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of cirrhosis

Presents with fluid retention as defined as ascites, edema, or pulmonary effusions requiring diuresis.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

Study Summary

This trial is testing whether adding albumin to diuretics helps people with cirrhosis and fluid retention.

Who is the study for?

This trial is for adults over 18 with cirrhosis who are dealing with fluid retention, like swelling or fluid in the lungs. It's not for those under 18, pregnant women, or patients with a creatinine level above 2 mg/dL (a sign of kidney problems).Check my eligibility

What is being tested?

The study tests if giving albumin (a blood protein) along with furosemide (a diuretic that helps get rid of excess water) works better than just furosemide alone in people with liver cirrhosis and fluid overload.See study design

What are the potential side effects?

Possible side effects include dehydration, electrolyte imbalances from furosemide leading to muscle cramps or weakness, and allergic reactions or infections from the albumin infusion.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with cirrhosis.

Select...

I am experiencing swelling or fluid build-up needing water pills.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Amount of urine

Change in weight

Secondary outcome measures

30-day readmission rates

Change in serum creatinine

Hospital length of stay

+1 more

Trial Design

2Treatment groups

Active Control

Group I: Furosemide (Lasix) aloneActive Control1 Intervention

Cohort 1 will receive furosemide (Lasix) 40 to 80 mg IVP BID for at least 48 hours

Group II: Combination of furosemide (Lasix) and albuminActive Control2 Interventions

Cohort 2 will receive combination of furosemide (Lasix) 40 to 80 mg IVP BID and albumin (25%) 12.5 grams IV BID for at least 48 hours

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor

422 Previous Clinical Trials

163,351 Total Patients Enrolled

Media Library

Furosemide Injection (Loop Diuretic) Clinical Trial Eligibility Overview. Trial Name: NCT04216784 — Phase 4

Liver Cirrhosis Research Study Groups: Furosemide (Lasix) alone, Combination of furosemide (Lasix) and albumin

Liver Cirrhosis Clinical Trial 2023: Furosemide Injection Highlights & Side Effects. Trial Name: NCT04216784 — Phase 4

Furosemide Injection (Loop Diuretic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04216784 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What therapeutic purpose does the amalgamation of furosemide (Lasix) and albumin serve?

"For the treatment of mediastinitis, furosemide (Lasix) and albumin are administered in tandem. It has further application for alleviating liver failure, acute edema, as well as preventing hypovolemia."

Answered by AI

What is the anticipated outcome of this clinical investigation?

"Over a time frame of 2-7 days, this trial will be assessing changes in weight while secondary outcomes include patient survival rate, alteration in renal function as measured by serum creatinine levels, and the number of readmissions within 30 days post-discharge."

Answered by AI

How many individuals are enrolled in this trial at present?

"Affirmative, the information on clinicaltrials.gov illustrates that this medicinal trial is currently enrolling participants. This endeavor was first announced on December 19th 2019 and most recently edited January 8th 2020. 150 people are needed to join from one single medical centre."

Answered by AI

Has the utilization of furosemide (Lasix) in tandem with albumin been ratified by the FDA?

"Due to the fact that this is a Phase 4 trial, implying that the combination of furosemide (Lasix) and albumin has already been approved, we rated its safety as 3."

Answered by AI

Are there still opportunities for individuals to participate in this experiment?

"As shown on clinicaltrials.gov, this medical trial is actively seeking participants; the initial post date was December 19th 2019 and edits were made as recent as January 8th 2020."

Answered by AI

Is this medical experiment the inaugural undertaking of its type?

"Since the 2007 pilot study sponsored by Celgene Corporation, which saw 47 participants trialling Combination of furosemide (Lasix) and albumin, this medication has been approved for Phase 1 & 2 drug trials. Currently, there are 147 active studies in 922 cities across 35 nations."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Comparison of Diuretic Effect With Furosemide Alone Versus the Combination of Furosemide and Albumin in Cirrhotic Patients

Nalvey 2019. "Comparison of Diuretic Effect With Furosemide Alone Versus the Combination of Furosemide and Albumin in Cirrhotic Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04216784.

All > Liver Cirrhosis