Combination of furosemide (Lasix) and albumin for Liver Cirrhosis

Rush University Medical Center, Chicago, IL
Liver Cirrhosis+2 More ConditionsFurosemide Injection - Drug
Eligibility
18+
All Sexes

Study Summary

This trial is testing whether adding albumin to diuretics helps people with cirrhosis and fluid retention.

Eligible Conditions
  • Liver Cirrhosis
  • Fluid Overload
  • Volume Overload

Treatment Effectiveness

Phase-Based Effectiveness

3 of 3
Phase 4
This is further along than 93% of similar trials

Study Objectives

2 Primary · 4 Secondary · Reporting Duration: 1 year

1 year
Patient survival
2-7 days
Amount of urine
Change in weight
30 days from discharge
30-day readmission rates
Year 1
Hospital length of stay
Day 7
Change in serum creatinine

Trial Safety

Phase-Based Safety

3 of 3
This is further along than 85% of similar trials

Awards & Highlights

Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

2 Treatment Groups

Combination of furosemide (Lasix) and albumin
1 of 2
Furosemide (Lasix) alone
1 of 2

Active Control

150 Total Participants · 2 Treatment Groups

Primary Treatment: Combination of furosemide (Lasix) and albumin · No Placebo Group · Phase 4

Combination of furosemide (Lasix) and albuminActiveComparator Group · 2 Interventions: Furosemide Injection, Albumin Human · Intervention Types: Drug, Drug
Furosemide (Lasix) alone
Drug
ActiveComparator Group · 1 Intervention: Furosemide Injection · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
396 Previous Clinical Trials
152,815 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

What therapeutic purpose does the amalgamation of furosemide (Lasix) and albumin serve?

"For the treatment of mediastinitis, furosemide (Lasix) and albumin are administered in tandem. It has further application for alleviating liver failure, acute edema, as well as preventing hypovolemia." - Anonymous Online Contributor

Unverified Answer

What is the anticipated outcome of this clinical investigation?

"Over a time frame of 2-7 days, this trial will be assessing changes in weight while secondary outcomes include patient survival rate, alteration in renal function as measured by serum creatinine levels, and the number of readmissions within 30 days post-discharge." - Anonymous Online Contributor

Unverified Answer

How many individuals are enrolled in this trial at present?

"Affirmative, the information on clinicaltrials.gov illustrates that this medicinal trial is currently enrolling participants. This endeavor was first announced on December 19th 2019 and most recently edited January 8th 2020. 150 people are needed to join from one single medical centre." - Anonymous Online Contributor

Unverified Answer

Has the utilization of furosemide (Lasix) in tandem with albumin been ratified by the FDA?

"Due to the fact that this is a Phase 4 trial, implying that the combination of furosemide (Lasix) and albumin has already been approved, we rated its safety as 3." - Anonymous Online Contributor

Unverified Answer

Are there still opportunities for individuals to participate in this experiment?

"As shown on clinicaltrials.gov, this medical trial is actively seeking participants; the initial post date was December 19th 2019 and edits were made as recent as January 8th 2020." - Anonymous Online Contributor

Unverified Answer

Is this medical experiment the inaugural undertaking of its type?

"Since the 2007 pilot study sponsored by Celgene Corporation, which saw 47 participants trialling Combination of furosemide (Lasix) and albumin, this medication has been approved for Phase 1 & 2 drug trials. Currently, there are 147 active studies in 922 cities across 35 nations." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.