Treatment for Breast Cancer

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Banner University Medical Center North Campus, Tucson, AZ
Breast Cancer+3 More
Eligibility
18+
Female
Eligible conditions
Select

Study Summary

This study is evaluating whether a drug which is not an opioid may help individuals with bone cancer pain.

See full description

Eligible Conditions

  • Breast Cancer
  • Chronic Pain Due to Malignancy (Finding)

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 1 secondary outcome in patients with Breast Cancer. Measurement will happen over the course of Twelve weeks.

Twelve weeks
Decrease opiate dose.
Overall pain relief.

Trial Safety

Safety Estimate

2 of 3
This is better than 68% of similar trials

Trial Design

2 Treatment Groups

Sulfasalazine
1 of 2
Placebos
1 of 2
Active Control
Non-Treatment Group

This trial requires 40 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.

Sulfasalazine
Drug
Subjects will receive the active drug.
Placebos
Drug
Subjects will receive sugar pill.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: twelve weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly twelve weeks for reporting.

Who is running the study

Principal Investigator
M. I.
Prof. Mohab Ibrahim, MD PhD
University of Arizona

Closest Location

Banner University Medical Center North Campus - Tucson, AZ

Eligibility Criteria

This trial is for female patients aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Adult patient age 18 - <95 years old capable of understanding and providing consent in English and capable of complying with the outcome used.
Diagnosis of cancer with pain moderate to severe pain on stable doses of opioids
3-day average numeric pain rating score (NPRS) for pain of at least 5/10 at baseline evaluation.
Patient consents to double blind design of the experiment in a shared decision- making process with the treating physician.
Pain duration of at least 6 weeks or more.
Prognosis greater than 6 months.
Able to take oral medication

Patient Q&A Section

Can chronic pain be cured?

"It is estimated that roughly one in three men and one in four women will experience chronic pain at some point in their lifetimes; the average duration of chronic pain is 17 years. However, recent studies have found that chronic pain is typically cured. More research is needed to determine the optimum approach for chronic pain management." - Anonymous Online Contributor

Unverified Answer

What are common treatments for chronic pain?

"The majority of chronic pain patients receive a variety of pharmacologic options, including antidepressants, anti-epileptics, anti-inflammatory agents, and a number of other treatments. These solutions are typically managed in a medical outpatient setting. A large portion of these patients receive medications that are inappropriate for their condition." - Anonymous Online Contributor

Unverified Answer

What causes chronic pain?

"Most individuals with [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) have no identifiable cause: most often, chronic pain can develop without a known diagnosis. The prevalence of chronic pain in primary care is high, and it can take months or even years to identify a cause. For some patients, a positive diagnosis can make pain better manageable, while for others treatment focused on its cause can improve patient satisfaction, and can improve quality of life as a result of improved coping skills." - Anonymous Online Contributor

Unverified Answer

What is chronic pain?

"Patients commonly complain that it is difficult to relax in the hospital. Chronic pain affects daily life and is a concern to patients and care providers all around the globe. It has important repercussions not only for quality of life of the patients, but also for the health system. The World Health Organization (WHO) has given this subject the title "World No. 1 Global Priority".\n" - Anonymous Online Contributor

Unverified Answer

How many people get chronic pain a year in the United States?

"Approximately 2.3 million adults per year are diagnosed with chronic pain in the US. Those 65 years old or older are two-and-a-half times more likely to be reported as having chronic pain than younger adults." - Anonymous Online Contributor

Unverified Answer

What are the signs of chronic pain?

"Patients need to realize that their doctor may not be able to tell them all the signs and symptoms of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain). The way they look and act could give them a good clue. The pain is getting worse and worse over time with no known cause or treatment. It might be time for a doctor's visit or new pain treatments. There could be some underlying cancer causing or treatment causing a constant level of pain. If no treatment is found, it might mean that chronic constant pain is not always, or even never, the cause. It might be an inherited (genetic) predisposition combined with a physical injury. You might need to see other types of specialists as well." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"The use of neurostimulation devices had advanced to be used in the treatment of [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) disorders since the 1920s, and several other neurostimulation devices were still or would be (e.g. vagus nerve stimulation), implanted in the 1950s and 1960s. The use of such devices may prove to be a viable alternative as a treatment for chronic pain when patients are unable to achieve satisfying pain relief through current therapies." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Approximately one-third of patients received two or more complementary treatments and about 1 in 5 patients received none. However, these treatments were commonly used in combination with each other and accounted for a significant proportion of the total healthcare expenditure." - Anonymous Online Contributor

Unverified Answer

Is treatment safe for people?

"People's beliefs and attitudes were not congruent with safety, and in many cases people were at risk or at least concerned as much about side effects as they were about the treatment itself." - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"We need to understand what we think about [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) and what our beliefs are about our pain and what we know about treatments before we start our treatments. One way to understand what we treatment that if there is a problem that a large portion of people with chronic pain are unable to cope with and manage their pain is to understand what people may be missing and to have a good understanding of the condition that they are experiencing." - Anonymous Online Contributor

Unverified Answer

What is the survival rate for chronic pain?

"The prevalence of persistent posttraumatic [chronic pain](https://www.withpower.com/clinical-trials/chronic-pain) is estimated to be 16 % in an adult population. The pain is severe and disabling, which results in increased risk for the development of psychiatric disorders and somatic complaints. The pain also has a negative impact on health-related quality of life and socioeconomic conditions in a population of pain sufferers." - Anonymous Online Contributor

Unverified Answer

What are the chances of developing chronic pain?

"It depends on what is defined as an appropriate age for preventive medicine and on how many people have been exposed to risk factors such as physical traumas. Data from a recent study confirm the high levels of chronic pain in Switzerland and are more than four times higher than reported in the German population." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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