Treatment for Breast Cancer

Phase-Based Estimates
3
Effectiveness
3
Safety
Ottawa Hospital Research Institute, Ottawa, Canada
Breast Cancer+1 More
Eligibility
18+
All Sexes
Eligible conditions
Breast Cancer

Study Summary

This study is evaluating whether a single dose of pegfilgrastim is as effective as 5 doses of daily filgrastim in reducing bone pain in breast cancer patients.

See full description

Eligible Conditions

  • Breast Cancer
  • Breast Neoplasms
  • Early-stage Breast Cancer

Treatment Effectiveness

Effectiveness Estimate

3 of 3
This is better than 93% of similar trials

Compared to trials

Study Objectives

This trial is evaluating whether Treatment will improve 1 primary outcome and 10 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of 2.5 years after study initiation.

Year 1
Study feasibility
Year 5
Cost-effectiveness
Differences in healthcare resource utilization
HR-QoL
Incidence of Febrile Neutropenia
Incidence of chemotherapy alteration
Incidence of chemotherapy-related mortality
Incidence of treatment-related hospitalizations
Patient G-CSF preference
Rate of G-CSF compliance as prescribed
Day 5
Bone pain

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Compared to trials

Trial Design

2 Treatment Groups

5 Days of Filgrastim

This trial requires 232 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.

5 Days of Filgrastim
Drug
Receive filgrastim subcutaneous injection once daily for five consecutive days starting 24-72 hours after chemotherapy.
Pegfilgrastim
Drug
Receive pegfilgrastim as a single dose subcutaneous injection 24-72 hours after chemotherapy

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 5 days after first g-csf injection
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 5 days after first g-csf injection for reporting.

Closest Location

Ottawa Hospital Research Institute - Ottawa, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Patients with early-stage or locally-advanced breast cancer receiving neoadjuvant or adjuvant chemotherapy requiring primary febrile neutropenia prophylaxis with G-CSF
Able to provide verbal consent
Able to complete questionnaires in English or French

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the latest research for breast cancer?

Add answer

This review summarizes the scientific and clinical advances in breast cancer therapeutics in the last 50 years. This review will be useful to patients, their families, and the health care providers from whom the information descends.

Unverified Answer

What causes breast cancer?

Add answer

Most cases of breast cancer are not related to what one takes on the job or what one is exposed to at home or at school. The vast majority of cases are due to genetic and environmental causes. There is also risk with exposure to occupational irradiation and asbestos. The risk is increased in women with a family history of breast cancer.\n

Unverified Answer

Can breast cancer be cured?

Add answer

Although it is possible to eradicate the disease in more than 50% of cases, cure does not seem to be achievable; however, the possibility may still persist, as in the case of early-stage MCRC (stage I or II) for which a cure is not yet achievable but which can still be eliminated with aggressive treatment.

Unverified Answer

What are common treatments for breast cancer?

Add answer

The current treatment of breast cancer in India is different than the treatments in developed countries where more than 80% of sufferers are treated with hormone therapy. Most Indian women receive hormone therapy when treatment with surgery and/or chemotherapy or radiotherapy have failed. Very rarely will a woman have one of the above treatments given to her together with surgery. It is important to provide an adequate referral to oncology for breast cancer sufferers. A breast cancer register should be established in all Indian hospitals. This will help to develop more accurate statistics on breast cancer.

Unverified Answer

How many people get breast cancer a year in the United States?

Add answer

Approximately 6 million women in the US are diagnosed with breast cancer each year. The rates of women diagnosed with breast cancer will continue to increase, largely as a result of the increase in American women living to an older age, and more women will be diagnosed on the basis of mammography rather than clinical evaluation.

Unverified Answer

What is breast cancer?

Add answer

Breast cancer is a cancer that forms in the breasts and are made up of cells that can form into a mass called a breast lumps, which is why most woman who had breast cancer complain of a lump in one or both breasts. The cells formed into a mass named as malignant tumors. This is why all cancer has the potential to spread. Most common types of breast cancer are; invasive ductal carcinoma (IDC), infiltrating ductal carcinoma, lobular carcinoma, or squamous cell carcinoma.

Unverified Answer

What are the signs of breast cancer?

Add answer

The presence of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) can be indicated by breast lump, nipple redness, nipple discharge, skin color change, or changes in the size, shape or consistency of breast. Breast cancer may also be indicated by a lump in the tissue of the breast, a feeling in the breast, pain in the breast, and unexplained bleeding from the nipple. A breast palpation will reveal the lump present. In a man, some symptoms may be signs of an enlarged prostate.\n

Unverified Answer

What is the average age someone gets breast cancer?

Add answer

Approximately 2 in 6 women are diagnosed with Breast cancer before the age of 50. Older age is associated with worse prognosis and worse survival. It is recommended that a woman over 10 years of age consider having a screening mammogram done to look for any changes that may suggest breast cancer.

Unverified Answer

What is the primary cause of breast cancer?

Add answer

Findings from a recent study of this study suggest the following. First, the majority of cancer patients are aware of breast cancer as a risk factor for women of their age when they have the first visit. Second, all participants were aware of the role of diet in preventing breast cancer and all understood it important to eat a healthy diet (especially folate, B vitamins and physical activity), and that a healthy lifestyle included not smoking, getting exercise regularly, weight control and avoiding alcohol and red wine. However, a majority of participants lacked a correct knowledge about the role of hormones, estrogen and androgens in breast cancer, especially menopausal hormone therapy. Findings from a recent study also suggest that certain social and cultural factors might play a significant role in influencing individuals to get screened.

Unverified Answer

Does breast cancer run in families?

Add answer

Data from a recent study suggest that non-BRCA-familial HBC is relatively rare, however, it represents the majority of HBC cases in Saudi Arabian families, suggesting that BRCA1 and BRCA2 mutations are relatively uncommon in Saudi families. Screening for breast cancer remains one of the main priorities of the Saudi authorities.

Unverified Answer

What does treatment usually treat?

Add answer

Most treatment used in [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) treatment is not aimed at the actual cause of the disease. It is treatment intended to treat symptoms, complications or complications associated with the advanced cancer. But for women and her caregivers who know that it may be difficult to be supportive, it is better to choose treatment based on what will provide the greatest benefit rather than be vague, confusing or merely an avoidance of symptom control.

Unverified Answer

Have there been any new discoveries for treating breast cancer?

Add answer

Breast cancers can be divided into three distinct categories: (1) ER-negative (2) triple negative, and (3) ER-positive cancers (Figure 32). Breast cancers, particularly those expressing ER, are increasingly being treated by targeted therapy with endocrine agents such as hormone receptor antagonists (selective and nonselective) and aromatase inhibitors (AIs). Selective endocrine therapies are increasingly being replaced by AIs because they have fewer side effects.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Breast Cancer by sharing your contact details with the study coordinator.