Focal Therapy for Prostate Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies the outcomes of focal therapy, a prostate cancer treatment that targets only the cancerous part of the prostate rather than the entire gland. Researchers aim to gather data to improve care for patients choosing this less invasive option. The trial suits individuals who have already chosen or received focal therapy for prostate cancer. Participants should have a PSA level of 20 or less. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to important findings.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that focal therapy is safe for prostate cancer patients?
Research shows that focal therapy for prostate cancer is usually well-tolerated. Studies have found that serious side effects occur in about 3% of patients, meaning most people do not experience severe problems. Some studies even report no side effects with certain types of focal therapy, such as cryotherapy and brachytherapy. Overall, focal therapy effectively controls cancer for several years while maintaining low side effects.12345
Why are researchers excited about this trial?
Focal therapy is unique because it targets only the cancerous part of the prostate, unlike traditional options like surgery or radiation, which can affect the entire gland. Researchers are excited because this approach aims to minimize side effects, such as incontinence and erectile dysfunction, by preserving as much healthy tissue as possible. This targeted method could offer a more precise and less invasive alternative for men with localized prostate cancer, potentially leading to quicker recovery times and improved quality of life.
What evidence suggests that focal therapy is effective for prostate cancer?
Research has shown that focal therapy, which participants in this trial may receive, is a promising treatment for prostate cancer that hasn't spread. One study found that focal therapy effectively controls cancer, with about 80% of men having no significant cancer in follow-up tests. Another study demonstrated that focal therapy has few side effects and remains effective even after five years. This treatment provides good control of the disease for up to 5–10 years, regardless of the specific techniques used. By targeting only the cancerous parts of the prostate, focal therapy helps protect the surrounding healthy tissue. Overall, these findings suggest that focal therapy can offer effective cancer treatment with fewer side effects.34678
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Focal Therapy
Participants undergo focal ablation of prostate tissue as part of their routine prostate cancer treatment
Follow-up
Participants are monitored for safety and effectiveness after focal therapy, including assessments of incontinence and erectile dysfunction using the EPIC-CP questionnaire
Long-term Follow-up
Participants are monitored for prostate cancer recurrence with PSA tests every 6 months and potential biopsies for up to 10 years
What Are the Treatments Tested in This Trial?
Interventions
- Focal Therapy
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Subjects who have biopsy-proven adenocarcinoma of the prostate, who have met all study inclusion and exclusion criteria, and have elected to receive or have already received focal therapy as part of their routine prostate cancer treatment, will be invited to participate in this observational registry study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Diego
Lead Sponsor
Citations
A Multicentre Study of 5-year Outcomes Following Focal ...
Focal HIFU therapy for patients with clinically significant prostate cancer that has not spread has a low probability of side effects and is effective at 5 yr.
Review article Advances in focal therapy for prostate cancer
Focal therapy (FT) has emerged as a promising treatment option for localized prostate cancer (PCa), offering oncologic control with reduced ...
3.
bjui-journals.onlinelibrary.wiley.com
bjui-journals.onlinelibrary.wiley.com/doi/full/10.1002/bco2.70000Focal therapy in prostate cancer: Development, application ...
This paper discusses the evolution, techniques, outcomes and future prospects of focal therapy for prostate cancer in the United Kingdom.
4.
euoncology.europeanurology.com
euoncology.europeanurology.com/article/S2588-9311(25)00039-2/fulltextOutcomes of Focal Therapy for Localized Prostate Cancer
We found that focal ablation of localized prostate cancer (PCa) is effective, with about 80% of men showing no significant cancer in biopsies ...
State-of-the-Art Lecture: Focal Therapy in Prostate Cancer
Focal therapy has demonstrated favorable locoregional disease control for up to 5–10 years, with reproducible outcomes that appear independent of energy source ...
Outcomes of Focal Therapy for Localized Prostate Cancer
Five-year radical and systemic treatment-free survival was 82% (95% CI: 75-88%). The pooled incidence of grade ≥3 AEs was 3% (95% CI: 2-5%). Pad ...
Outcomes of Focal Therapy for Localized Prostate Cancer
Five-year radical and systemic treatment–free survival was 82% (95% CI: 75–88%). The pooled incidence of grade ≥3 AEs was 3% (95% CI: 2–5%). Pad ...
Functional outcomes and safety of focal therapy for ...
In our review, 6 studies reported no adverse event at all (2 on cryotherapy, 2 on focal brachytherapy, 1 on FLA and 1 on microwave). Overall, ...
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