Stem Cell Transplant Clinical Trials
Here are the 6 most popular medical studies for stem cell transplant
Alkylating agents
Cyclophosphamide + TBI + IMRT + Stem Cell Transplantation for Systemic Sclerosis
This trial is testing the side effects and feasibility of a new way to give total body radiation therapy (IMRT) with the chemotherapy drug cyclophosphamide before stem cell transplant to treat severe systemic sclerosis.
Hematopoietic Stem Cell Transplantation
Stem Cell Transplantation and Tregs Therapy for Kidney Transplant
This trial will test whether a combination of radiation and drugs followed by infusion of donor cells will allow recipients to eventually stop taking anti-rejection drugs after receiving a kidney from a living donor.
Popular filter options for stem cell transplant trials
Multiple Myeloma Clinical Trials
View 32 Multiple Myeloma medical studies.
Behavioural Intervention
Multidisciplinary Approach for Blood Cancers
This trial is studying a multidisciplinary intervention to help older adults with blood cancers who are planning a stem cell transplant. The intervention includes multiple healthcare professionals and is aimed at improving fitness and the ability to bounce back after transplant.
Acute Myelogenous Leukemia Clinical Trials
View 31 Acute Myelogenous Leukemia medical studies.
Behavioural Intervention
Multidisciplinary Approach for Blood Cancers
This trial is studying a multidisciplinary intervention to help older adults with blood cancers who are planning a stem cell transplant. The intervention includes multiple healthcare professionals and is aimed at improving fitness and the ability to bounce back after transplant.
HLA Positive Clinical Trials
View 16 HLA positive medical studies.
T-cell Therapy
CMVpp65 T-cell Therapy for CMV Infection
This trial is testing whether transfusions of T-cells can help treat CMV infection. T-cells are a type of white blood cell that helps protect the body from infection. In this case, the T-cells are made from the blood of donors who are immune to CMV. The T-cells are then grown and taught to attack the CMV virus in a lab.
HLA-A Positive Clinical Trials
View 9 HLA-A positive medical studies.
Alkylating agents
2-Step Stem Cell Transplant for Blood Cancers
This trial is testing a two-step stem cell transplant approach to treating blood cancers. The first step is chemotherapy and total body irradiation, followed by a transplant of healthy lymphocytes and stem cells from a donor. The trial will test how well this approach works and if it can help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets.
Janus Kinase (JAK) Inhibitor
Ruxolitinib + Chemotherapy + Stem Cell Transplant for Myelofibrosis
This trial is testing the side effects and best dose of a drug when given with chemotherapy before and after a stem cell transplant to treat patients with cancer of the bone marrow.
Histone Deacetylase Inhibitor
Vorinostat + Combination Chemotherapy for Non-Hodgkin Lymphoma
This trial is studying vorinostat in combination with chemotherapy before a stem cell transplant to see how well it works compared to chemotherapy alone in treating patients with relapsed aggressive B-cell or T-cell non-Hodgkin lymphoma.
Phase 3 Stem Cell Transplant Clinical Trials
View 96 phase 3 stem cell transplant medical studies.
Behavioural Intervention
AAT + Corticosteroids for GVHD in HSCT Recipients
This trial will compare the effectiveness of a combination of AAT and corticosteroids to corticosteroids alone as the first treatment for patients at high risk for developing acute GVHD.
Alkylating agents
Combination Therapy + Stem Cell Transplant for Rhabdoid Tumor
This trial is testing a combination of chemotherapy, radiation therapy, and stem cell transplant to treat atypical teratoid/rhabdoid tumor of the central nervous system in young patients.
Retinoid
Isotretinoin +/- Dinutuximab, Aldesleukin, and Sargramostim for Neuroblastoma
This trial will compare isotretinoin alone to isotretinoin with dinutuximab, aldesleukin, and sargramostim following stem cell transplant in treating patients with neuroblastoma.
Stem Cell Transplant Clinical Trials With No Placebo
View 96 stem cell transplant medical studies that do not have a placebo group.
Behavioural Intervention
Multidisciplinary Approach for Blood Cancers
This trial is studying a multidisciplinary intervention to help older adults with blood cancers who are planning a stem cell transplant. The intervention includes multiple healthcare professionals and is aimed at improving fitness and the ability to bounce back after transplant.
View More Stem Cell Transplant Trials
See another 58 many medical studies focused on stem cell transplant.
Frequently Asked Questions
Introduction to stem cell transplant
What are the top hospitals conducting stem cell transplant research?
When it comes to cutting-edge research in stem cell transplant, several top hospitals are leading the way. Located in Duarte, California, the City of Hope Medical Center stands out with ten active clinical trials focused on this groundbreaking treatment method. Stem cell transplantation offers hope for patients with a range of conditions by replacing damaged or diseased cells with healthy ones derived from their own bodies or donated sources. Meanwhile, across the country in New York City, Memorial Sloan Kettering Cancer Center is also making strides in this field with nine ongoing trials dedicated to stem cell transplants. Their efforts aim to improve outcomes and expand the potential applications of this transformative therapy.
In Houston, Texas, M D Anderson Cancer Center is at the forefront too; they have eight active clinical trials exploring various aspects of stem cell transplantations. This innovative technique has been proven effective for treating blood cancers like leukemia and lymphoma as well as certain genetic disorders and immune deficiencies.
Notably contributing to this progress is Washington, California, the City of Hope Medical Center stands out with ten active clinical trials focused on this groundbreaking treatment method. Stem cell transplantation offers hope for patients with a range of conditions by replacing damaged or diseased cells with healthy ones derived from their own bodies or donated sources. Meanwhile, across the country in New York City, Memorial Sloan Kettering Cancer Center is also making strides in this field with nine ongoing trials dedicated to stem cell transplants. Their efforts aim to improve outcomes and expand the potential applications of this transformative therapy.
In Houston, Texas, M D Anderson Cancer Center is at the forefront too; they have eight active clinical trials exploring various aspects of stem cell transplantations. This innovative technique has been proven effective for treating blood cancers like leukemia and lymphoma as well as certain genetic disorders and immune deficiencies.
Notably contributing to this progress is Washington University School of Medicine located in Saint Louis which currently has eight ongoing initiatives aimed towards understanding better how we can benefit from these treatments further.Held alongside these impressive institutions' work lies another central institution based back at Duarte itself: City of Hope Comprehensive Cancer Center; here they boast an array seven actively performed experiments exploring benefits associated with applying stem-cell-transplant methods on different patient groups suffering from a varietyof diseases.
The pioneering work conducted by these esteemed medical centers signifies significant advancements not just within specific regions but throughout national healthcare systems as well — offering renewed hope for countless individuals seeking life-saving solutions through stem cell transplantation.
Which are the best cities for stem cell transplant clinical trials?
When it comes to stem cell transplant clinical trials, several cities have emerged as leaders in research and development. Chicago, Illinois, and Boston, Massachusettsl transplant clinical trials, several cities have emerged as leaders in research and development. Chicago, Illinois, and Boston, Massachusetts both offer 22 active trials exploring innovative treatments such as pharmacological studies, autologous hematopoietic stem cell transplantation, and interleukin-2 interventions. New York City follows closely behind with 19 ongoing trials focused on methotrexate treatment and gene-modified T cells targeted therapies. Additionally, Duarte, California showcases 18 active trials investigating multi-peptide CMV-modified vaccinia Ankara vaccines and allogeneic hematopoietic stem cell transplantation. Finally, Seattle, Washington offers 17 trials centered around autologous and allogeneic hematopoietic stem cell transplantation. These cities serve as hubs of cutting-edge research in the field of stem cell transplants for those seeking advanced treatment options.
Which are the top treatments for stem cell transplant being explored in clinical trials?
The field of stem cell transplant is witnessing exciting advancements through ongoing clinical trials. Leading the charge are three standout treatments, each showing great promise in their respective studies:
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Daratumumab: Currently being explored in six active trials for stem cell transplant.
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Belantamab mafodotin: Showing potential in four ongoing clinical trials.
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**Lenalidomidel transplant is witnessing exciting advancements through ongoing clinical trials. Leading the charge are three standout treatments, each showing great promise in their respective studies:
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Daratumumab: Currently being explored in six active trials for stem cell transplant.
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Belantamab mafodotin: Showing potential in four ongoing clinical trials.
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Lenalidomide: Under investigation in three active studies.
These treatments have captured the attention of researchers due to their encouraging results and potential to revolutionize the field of stem cell transplantation.
What are the most recent clinical trials for stem cell transplant?
The field of stem cell transplant is advancing rapidly, with recent clinical trials offering new insights and potential treatments. One noteworthy trial is Arm A, a Phase 3 study that explores the effectiveness of stem cell transplantation. Additionally, another Phase 2 trial investigates the benefits of CD34+ Peripheral Blood Progenitor Cell (PBSC) Transplantation using a Busulfan/Melphalan/Fludarabine Regimen. Patients with various conditions such as AML, ALL, MDS, MPN, CML, NHL, HD, CLL, MDS, MPN, CML, NHL, HD, CLL requiring AHSCT are also partaking in a Phase 2 trial to assess the outcomes of their stem cell transplants. Another significant study focuses on allogeneic hematopoietic stem cell transplantation for patients seeking this form of treatment. The development and evaluation of fostamatinib for use in conjunction with stem cell transplant rounds out these latest trials—an exciting prospect for enhancing patient care and outcomes in this field.
What stem cell transplant clinical trials were recently completed?
Recently, several stem cell transplant clinical trials have reached completion, bringing hope to patients seeking innovative treatments. In March 2021, the University of California San Francisco concluded their trial investigating the effectiveness of autologous stem cell transplantation for multiple myelomal transplant clinical trials have reached completion, bringing hope to patients seeking innovative treatments. In March 2021, the University of California San Francisco concluded their trial investigating the effectiveness of autologous stem cell transplantation for multiple myeloma patients. Similarly, in January 2021, a study led by Memorial Sloan Kettering Cancer Center examined allogeneic stem cell transplantation as a potential therapy for acute myeloid leukemia and related disorders. These significant milestones highlight advancements in utilizing stem cells to combat these challenging diseases and pave the way for future breakthroughs.