NanoScope™ Operative Arthroscopy (Arthrex, Inc) for Arthrosis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Albany Medical Center, Albany, NY
Arthrosis+2 More
NanoScope™ Operative Arthroscopy (Arthrex, Inc) - Device
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether a procedure can be used to confirm the presence of unicompartmental knee OA and guide patient management in the decision to perform UKA or TKA.

See full description

Eligible Conditions

  • Arthrosis
  • Arthroplasties, Replacement, Knee

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether NanoScope™ Operative Arthroscopy (Arthrex, Inc) will improve 1 primary outcome in patients with Arthrosis. Measurement will happen over the course of 1 day.

1 day
Visualization of unicompartmental or tricompartmental osteoarthritis

Trial Safety

Safety Progress

1 of 3

Trial Design

1 Treatment Group

Unicompartmental OA or equivocal findings in XR
1 of 1
Experimental Treatment

This trial requires 110 total participants across 1 different treatment group

This trial involves a single treatment. NanoScope™ Operative Arthroscopy (Arthrex, Inc) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Unicompartmental OA or equivocal findings in XR
Device
After obtaining informed consent, patients will undergo needle arthroscopy, performed in the operating room prior to undergoing arthroplasty

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 day
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1 day for reporting.

Who is running the study

Principal Investigator
J. Z.
Joseph Zimmerman, MD
Albany Medical College

Closest Location

Albany Medical Center - Albany, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
English fluency and literacy
Able to provide informed consent
Males or females, > 18 years of age and < 89
Indicated for unicompartmental knee arthroplasty based on a series of existing weight bearing knee plain radiographs
Have equivocal weight bearing knee radiographs, in which the indication for UKA vs. TKA is not clear
Meet the following criteria: no inflammatory arthritis, intact Anterior cruciate ligament, no fixed varus deformity > 10 degrees, no fixed valgus deformity > 5 degrees, knee range of motion > 90 degrees, no patellofemoral arthritis

Patient Q&A Section

What are common treatments for osteoarthritis, knee?

"The data were limited in terms of the number of treatments and the treatments were not consistently or consistently effective in all patients. Most treatment modalities were used in different patients." - Anonymous Online Contributor

Unverified Answer

What is osteoarthritis, knee?

"Osteoarthritis of the knee is a condition caused by gradual breakdown of cartilage with pain, swelling and stiffness over time. There are many subtypes, most notably osteoarthritis of the knee, which often appears in people over the age of 60. It affects more than just the knee, it also affects other joints such as the hip and shoulder. Patients with arthritis are frequently advised to take some form of medication to control their pain and improve mobility and to maintain a level of function and quality of life. Osteoarthritis of the knee can be identified by blood tests and X-rays at the workplace, with the aim of preventing further progression and pain." - Anonymous Online Contributor

Unverified Answer

How many people get osteoarthritis, knee a year in the United States?

"By 2050, nearly 1 million new knee cases will be diagnosed. This has implications for the development of strategies to prevent knee OA, as well as the provision of treatment for those that have it." - Anonymous Online Contributor

Unverified Answer

What causes osteoarthritis, knee?

"Risk factors for OA are generally shared with other joints, and in OA there are several key genetic factors. However, these factors play a relatively minor role in developing OA. Obesity has a role in worsening OA, but it is not the underlying cause." - Anonymous Online Contributor

Unverified Answer

Can osteoarthritis, knee be cured?

"The present study has demonstrated that the use of an AAS, and in particular, the use of AAS+DHA, have a positive effect on OA of the lower limb." - Anonymous Online Contributor

Unverified Answer

What are the signs of osteoarthritis, knee?

"Signs of OA include pain, joint stiffness and limitation of range of motion. Pain, or symptoms of knee pain, stiffness, decreased range of motion, and difficulty performing activities of daily living are all commonly reported by knee OA patients. The joint is most commonly tender and swollen. Osteoarthritis of the knee is the most common joint affected by osteoarthritis.  \n" - Anonymous Online Contributor

Unverified Answer

What are the common side effects of nanoscope™ operative arthroscopy (arthrex, inc)?

"Nanoscope Inc performed more arthroscopic knee surgery, knee arthroscopic surgeries per year than [Power (https://www.withpower.com/clinical-trials)/Operative Joint Arthroscopy] in the United States, a study [published online in 2015." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving nanoscope™ operative arthroscopy (arthrex, inc)?

"Arthroscope for intra-articular knee surgery is a well-established technology. The use of nanoscale(s) in arthroscopy is new and represents a new and potentially innovative approach compared to conventional arthroscopy. Since other randomized controlled trials have already been shown that conventional arthroscopy is just as effective as arthoscopy, it would be reasonable to expect this technique to yield equivalent results. Until then, it is important to continue using what we have and learn how to get the best benefits using the tool at our disposal." - Anonymous Online Contributor

Unverified Answer

Is nanoscope™ operative arthroscopy (arthrex, inc) safe for people?

"In a recent study, findings indicate that arthroscopy with Nanoscope™ generates moderate pain compared to a conventional arthroscope, and it is generally safe to perform on volunteers on an outpatient basis. Arthroscopic procedures in non-consecutive volunteers may benefit from inclusion in the study so that the potential benefit may be calculated more precisely." - Anonymous Online Contributor

Unverified Answer

Does osteoarthritis, knee run in families?

"OA, as an endocrine disease, may be an important, hitherto unknown hereditary [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). The fact that the families included in this study had a similar phenotype may suggest inheritance of osteoarthritis of a similar disease entity. As more families are studied, this hypothesis will likely be confirmed and OA, a very disabling disease with a large impact on quality of life of the persons experiencing this disease." - Anonymous Online Contributor

Unverified Answer

Is nanoscope™ operative arthroscopy (arthrex, inc) typically used in combination with any other treatments?

"Combined arthroscopic knee surgeries such as arthrits surgeries and meniscal surgeries resulted in higher improvement rates and improvement of pain compared to solitary knee surgery (arthritis revision/deformity, meniscal/bundle allograft surgery, reconstruction/regimen replacement surgery)." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating osteoarthritis, knee?

"The two most common medications for OA are non-steroidal anti-inflammatory drugs (NSAIDs) and NSAID-alternatives. For OA patients who are not satisfied by NSAID use, it is feasible to administer paracetamol (acetaminophen) as an alternative, because it lacks the adverse effects of NSAIDs without offering the analgesic effects like NSAIDs. For patients who are dissatisfied with NSAID use, other drugs such as corticosteroids are acceptable to treat to control the inflammatory reaction of the knee." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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