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Procedure

Knee Replacement Surgeries for Osteoarthritis

Q: Does the research necessitate participants to be octogenarians or younger?

Qualified participants must be in their forties to eighties. There are 38 trials dedicated to minors and 657 clinical studies specifically catering to those above the retirement age.

Q: What are the prerequisites for participation in this research initiative?

To be eligible for this study, individuals must have been diagnosed with arthrosis and aged between 40-80 years. In total, 38 patients will join the trial.

Q: Are there any current vacancies in this clinical trial?

Analysis of clinicaltrials.gov reveals that recruitment for this medical trial has ended, as the first post was on February 1st 2016 and last update was made on February 8th 2021. Nonetheless, there are still 693 other studies actively looking to enroll patients right now.

N/A

Waitlist Available

Led By Kelly D Johnston, MD

Research Sponsored by Alberta Hip and Knee Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Angular deformity <15 degrees passively correctible to neutral

Flexion contracture <5 degrees

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial is comparing two different types of knee surgery to see which one works better for people with no to moderate anteromedial knee osteoarthritis.

Who is the study for?

This trial is for people aged 40-80 with anteromedial knee osteoarthritis, a BMI under 40, and an intact ACL. They should have normal or mild to moderate patellofemoral joint OA and no severe deformities or previous major surgeries on the affected knee.Check my eligibility

What is being tested?

The study compares two types of knee surgery: Total Knee Arthroplasty (TKA) using Zimmer Persona implants versus Unicompartmental Knee Arthroplasty (UKA) using Biomet Oxford implants. It measures outcomes like pain, function, and gait over two years.See study design

What are the potential side effects?

Potential side effects include pain at the surgery site, swelling, infection risk, blood clots in the legs or lungs, stiffness in the knee joint after surgery, and possible need for revision surgery.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My joint can almost straighten out fully on its own.

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My joint bends almost fully, with less than 5 degrees of limitation.

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My knee arthritis is in a specific area and my ACL is not damaged.

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My knee pain is due to mild or moderate arthritis.

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I am between 40 and 80 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Antigens, Tumor-Associated, Carbohydrate

Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Secondary outcome measures

Gait analysis score

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Unicompartment knee arthroplasty/OxfordExperimental Treatment2 Interventions

Unicompartmental knee arthroplasty with Biomet Oxford mobile-bearing unicompartmental knee prosthesis (Biomet, Warsaw, IN)

Group II: Total knee arthroplasty/PersonaActive Control2 Interventions

Total knee arthroplasty with Zimmer Persona posterior cruciate retaining prosthesis (Zimmer, Warsaw, IN)

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

Alberta Hip and Knee ClinicLead Sponsor

3 Previous Clinical Trials

320 Total Patients Enrolled

2 Trials studying Osteoarthritis

220 Patients Enrolled for Osteoarthritis

Kelly D Johnston, MDPrincipal InvestigatorUniversity of Calgary Cumming School of Medicine

Media Library

Total knee arthroplasty (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT02430129 — N/A

Osteoarthritis Research Study Groups: Total knee arthroplasty/Persona, Unicompartment knee arthroplasty/Oxford

Osteoarthritis Clinical Trial 2023: Total knee arthroplasty Highlights & Side Effects. Trial Name: NCT02430129 — N/A

Total knee arthroplasty (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02430129 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the research necessitate participants to be octogenarians or younger?

"Qualified participants must be in their forties to eighties. There are 38 trials dedicated to minors and 657 clinical studies specifically catering to those above the retirement age."

Answered by AI

What are the prerequisites for participation in this research initiative?

"To be eligible for this study, individuals must have been diagnosed with arthrosis and aged between 40-80 years. In total, 38 patients will join the trial."

Answered by AI

Are there any current vacancies in this clinical trial?

"Analysis of clinicaltrials.gov reveals that recruitment for this medical trial has ended, as the first post was on February 1st 2016 and last update was made on February 8th 2021. Nonetheless, there are still 693 other studies actively looking to enroll patients right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Unicondylar Knee Arthroplasty Versus Total Knee Arthroplasty in Patients With Anteromedial Osteoarthritis of the Knee

Kelly Johnston 2016. "Unicondylar Knee Arthroplasty Versus Total Knee Arthroplasty in Patients With Anteromedial Osteoarthritis of the Knee". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02430129.

All > Osteoarthritis > Oa