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Total knee replacement with synovectomy for Osteoarthritis

N/A

Recruiting

Research Sponsored by Lawson Health Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up ultrasound: before surgery, 3 and 6 months post-surgery, samples: intra-operatively

Awards & highlights

Study Summary

This trial aims to investigate the benefits of performing synovectomy during total knee arthroplasty (TKA) in patients with severe joint pain caused by synovitis. Synovectomy involves removing

Who is the study for?

This trial is for men and women over 40 with knee osteoarthritis, scheduled for their first total knee replacement. They must have moderate to severe joint inflammation as shown by ultrasound. Participants are being accepted from a specific hospital's Pre-Admission Clinic.Check my eligibility

What is being tested?

The study tests if removing the inflamed tissue lining during knee replacement surgery (synovectomy) can reduce pain after the operation. Patients will be randomly assigned to receive either standard surgery or surgery with synovectomy, and their pain levels and quality of life will be compared before and after.See study design

What are the potential side effects?

Potential side effects may include typical surgical risks like infection or bleeding, increased pain initially post-surgery due to the additional procedure, and possibly delayed healing or recovery time.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ ultrasound: before surgery, 3 and 6 months post-surgery, samples: intra-operatively

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~ultrasound: before surgery, 3 and 6 months post-surgery, samples: intra-operatively

This trial's timeline: 3 weeks for screening, Varies for treatment, and ultrasound: before surgery, 3 and 6 months post-surgery, samples: intra-operatively for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Patients' self-reported level of pain

Secondary outcome measures

Activities of daily living sub-scale of the Knee injury and Osteoarthritis Outcome Score (KOOS)

Inflammation

Joint function - 30-Second Sit to Stand Test

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Total knee replacement with synovectomyExperimental Treatment1 Intervention

Patients in this arm will undergo synovectomy during total knee replacement surgery.

Group II: Total knee replacement without synovectomyActive Control1 Intervention

Patients in this arm will not undergo synovectomy during total knee replacement surgery.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor

659 Previous Clinical Trials

413,670 Total Patients Enrolled

21 Trials studying Osteoarthritis

5,505 Patients Enrolled for Osteoarthritis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment for participants currently open in this medical study?

"As per the data on clinicaltrials.gov, this study is actively seeking participants. The trial was first listed on November 20th, 2023, and most recently revised on February 28th, 2024."

Answered by AI

Who meets the eligibility criteria to participate in this medical study?

"Individuals aged between 41 and 80 years old diagnosed with osteoarthritis are eligible to participate in this research. The trial has a capacity of enrolling 62 participants."

Answered by AI

How many individuals in total will be participating in this medical study?

"Indeed, information from clinicaltrials.gov indicates that this study is actively seeking participants. The trial was first registered on November 20th, 2023 and last updated on February 28th, 2024. It aims to recruit a total of 62 patients at one designated site."

Answered by AI

Do participants younger than 65 meet the criteria for this study?

"Eligible individuals for this investigation must be aged between 41 and 80 years old. Furthermore, there are a total of 31 research projects focusing on participants under 18 years old and another 602 studies targeting those over the age of 65."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty

Brent Lanting 2023. "The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05800457.

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