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Joint Replacement

Partial vs Total Knee Replacement for Osteoarthritis

N/A
Waitlist Available
Led By Kevin Fricka, MD
Research Sponsored by Anderson Orthopaedic Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Knee flexion greater than 90 degrees
Varus deformity less than 20 degrees
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This trial finds that for patients with medial compartment osteoarthritis, UKA results in better function and less pain than TKA.

Who is the study for?
This trial is for people with severe osteoarthritis in one part of the knee, who can bend their knee well and don't have too much leg curvature. It's not for those who are very overweight or have diabetes that isn't well-controlled, serious kidney or liver disease, a history of drug abuse, inflammatory arthritis, or past infections in the joint.Check my eligibility
What is being tested?
The study compares two surgical procedures for knee osteoarthritis: unicompartmental (partial) and total knee replacement. Patients will be randomly assigned to receive one of these surgeries to see which is better at improving outcomes.See study design
What are the potential side effects?
Possible side effects include pain at the surgery site, swelling, infection risk increase after surgery, blood clots in legs or lungs (thromboembolism), stiffness in the knee joint and problems with implant like loosening over time.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can bend my knee more than 90 degrees.
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My leg's inward curve is less than 20 degrees.
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I have arthritis in the inner part of my knee.
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My joint bends less than 10 degrees when I try to straighten it.
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I have severe damage in the inner part of my knee.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Knee Society Score
Secondary outcome measures
Revision

Trial Design

2Treatment groups
Active Control
Group I: UKAActive Control1 Intervention
Medial unicompartmental knee arthroplasty
Group II: TKAActive Control1 Intervention
Total knee arthroplasty

Find a Location

Who is running the clinical trial?

Rush University Medical CenterOTHER
418 Previous Clinical Trials
162,387 Total Patients Enrolled
25 Trials studying Osteoarthritis
3,126 Patients Enrolled for Osteoarthritis
Anderson Orthopaedic Research InstituteLead Sponsor
13 Previous Clinical Trials
1,508 Total Patients Enrolled
8 Trials studying Osteoarthritis
1,038 Patients Enrolled for Osteoarthritis
Kevin Fricka, MDPrincipal InvestigatorAnderson Orthopaedic Institute

Media Library

Total Knee Arthroplasty (Joint Replacement) Clinical Trial Eligibility Overview. Trial Name: NCT03385759 — N/A
Osteoarthritis Research Study Groups: UKA, TKA
Osteoarthritis Clinical Trial 2023: Total Knee Arthroplasty Highlights & Side Effects. Trial Name: NCT03385759 — N/A
Total Knee Arthroplasty (Joint Replacement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03385759 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What prerequisites must prospective participants fulfill before they can join this medical trial?

"This clinical trial is seeking 112 participants between the ages of eighteen and seventy-five with knee injuries. To be eligible, applicants must meet these criteria."

Answered by AI

Is this trial excluding individuals over the age of 70?

"Eligibility for this experimental study necessitates that applicants are aged between 18 to 75. This trial has 38 slots availbale for younger patients and 657 openings earmarked for senior citizens."

Answered by AI

Are recruitment efforts presently underway for this trial?

"As reflected on clinicaltrials.gov, this medical trial is no longer actively recruiting patients. Initially posted May 22nd 2018 and most recently edited November 9th 2022, the protocol has reached its recruitment quota. Nonetheless, 693 other studies are still enrolling participants currently across numerous locations worldwide."

Answered by AI

Who else is applying?

What state do they live in?
District of Columbia
Virginia
How old are they?
18 - 65
What site did they apply to?
Anderson Orthopaedic Research Institute
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

First, I am willing to try anything that will help alleviate some of the discomfort. Second, I hope to make a contribution to my community.
PatientReceived 2+ prior treatments
~16 spots leftby Mar 2025