Partial vs Total Knee Replacement for Osteoarthritis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial evaluates which type of knee surgery is more effective for individuals with a specific type of knee arthritis. It compares partial knee replacement, which repairs only the damaged part of the knee, to total knee replacement (also known as Total Knee Arthroplasty), where the entire knee joint is replaced. Suitable candidates typically have arthritis primarily on the inner part of their knee and can bend their knee fairly well. As an unphased trial, this study provides participants the chance to contribute to valuable research that may enhance surgical outcomes for future patients.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that both partial knee replacement (UKA) and total knee replacement (TKA) have been studied for safety in people with knee arthritis.
For UKA, some studies have shown good short-term results, with patients experiencing less pain and improved mobility. However, nearly 40% of patients later required a switch to TKA. This indicates that while UKA can initially be effective, some individuals might need additional surgery.
TKA has a strong history of success. Studies found that most patients experienced less pain and improved mobility after surgery. About 78% of patients reported satisfaction with their knee function a year post-surgery.
Overall, both treatments are generally safe. However, UKA might lead to more surgery for some. Prospective trial participants should discuss options with their doctor to determine the best course of action.12345Why are researchers excited about this trial?
Researchers are excited about these treatments for osteoarthritis because they offer tailored approaches to knee replacement. Unlike the standard total knee replacement, which involves replacing the entire knee joint, the unicompartmental knee arthroplasty (UKA) focuses only on the damaged compartment of the knee. This can lead to a quicker recovery, less pain, and a more natural knee function post-surgery. By comparing partial and total knee replacements, researchers hope to find out which method offers the best outcomes for patients, potentially leading to more personalized treatment options.
What evidence suggests that this trial's treatments could be effective for osteoarthritis?
This trial will compare partial knee replacement (UKA) and total knee replacement (TKA) for knee arthritis. Studies have shown that both UKA and TKA effectively treat this condition. Participants in the UKA arm may experience quicker pain relief and faster recovery, with a lower risk of infection compared to those in the TKA arm. However, TKA offers long-lasting benefits, significantly reducing pain and improving knee function for many years. Both treatments can enhance quality of life, but they suit different patients based on individual needs and conditions.36789
Who Is on the Research Team?
Kevin Fricka, MD
Principal Investigator
Anderson Orthopaedic Institute
Are You a Good Fit for This Trial?
This trial is for people with severe osteoarthritis in one part of the knee, who can bend their knee well and don't have too much leg curvature. It's not for those who are very overweight or have diabetes that isn't well-controlled, serious kidney or liver disease, a history of drug abuse, inflammatory arthritis, or past infections in the joint.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgery
Participants undergo either unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA)
Follow-up
Participants are monitored for safety and effectiveness after surgery
What Are the Treatments Tested in This Trial?
Interventions
- Total Knee Arthroplasty
- Unicompartmental Knee Arthroplasty
Total Knee Arthroplasty is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Severe knee pain and disability due to rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
- Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
- Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
- Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
- Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
- Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
Find a Clinic Near You
Who Is Running the Clinical Trial?
Anderson Orthopaedic Research Institute
Lead Sponsor
Rush University Medical Center
Collaborator