112 Participants Needed

Partial vs Total Knee Replacement for Osteoarthritis

Recruiting at 1 trial location
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Anderson Orthopaedic Research Institute
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This study is a prospective, randomized trial to compare patient outcomes of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for the treatment of medial compartment osteoarthritis.

Who Is on the Research Team?

KF

Kevin Fricka, MD

Principal Investigator

Anderson Orthopaedic Institute

Are You a Good Fit for This Trial?

This trial is for people with severe osteoarthritis in one part of the knee, who can bend their knee well and don't have too much leg curvature. It's not for those who are very overweight or have diabetes that isn't well-controlled, serious kidney or liver disease, a history of drug abuse, inflammatory arthritis, or past infections in the joint.

Inclusion Criteria

I can bend my knee more than 90 degrees.
My leg's inward curve is less than 20 degrees.
I have arthritis in the inner part of my knee.
See 2 more

Exclusion Criteria

Body mass index over 40
I have inflammatory arthritis.
Hemoglobin A1c over 8.0
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Surgery

Participants undergo either unicompartmental knee arthroplasty (UKA) or total knee arthroplasty (TKA)

1 day

Follow-up

Participants are monitored for safety and effectiveness after surgery

2 years

What Are the Treatments Tested in This Trial?

Interventions

  • Total Knee Arthroplasty
  • Unicompartmental Knee Arthroplasty
Trial Overview The study compares two surgical procedures for knee osteoarthritis: unicompartmental (partial) and total knee replacement. Patients will be randomly assigned to receive one of these surgeries to see which is better at improving outcomes.
How Is the Trial Designed?
2Treatment groups
Active Control
Group I: UKAActive Control1 Intervention
Medial unicompartmental knee arthroplasty
Group II: TKAActive Control1 Intervention
Total knee arthroplasty

Total Knee Arthroplasty is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:

πŸ‡ͺπŸ‡Ί
Approved in European Union as Total Knee Arthroplasty for:
  • Severe knee pain and disability due to rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
πŸ‡ΊπŸ‡Έ
Approved in United States as Total Knee Replacement for:
  • Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
πŸ‡¨πŸ‡¦
Approved in Canada as Total Knee Arthroplasty for:
  • Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
πŸ‡―πŸ‡΅
Approved in Japan as Total Knee Replacement for:
  • Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
πŸ‡¨πŸ‡³
Approved in China as Total Knee Arthroplasty for:
  • Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle
πŸ‡¨πŸ‡­
Approved in Switzerland as Total Knee Replacement for:
  • Severe knee pain and disability due to degenerative joint disease, rheumatoid arthritis, osteoarthritis, traumatic arthritis, polyarthritis, collagen disorders, and avascular necrosis of the femoral condyle

Find a Clinic Near You

Who Is Running the Clinical Trial?

Anderson Orthopaedic Research Institute

Lead Sponsor

Trials
14
Recruited
1,600+

Rush University Medical Center

Collaborator

Trials
448
Recruited
247,000+
Unbiased ResultsWe believe in providing patients with all the options.
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