LungTalk for Increasing Lung Cancer Screening

Overseen By Francis Valenzona

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Hackensack Meridian Health

Disqualifiers: Lung cancer, Impaired decision-making, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

500 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial uses a program called LungTalk and Facebook ads to encourage high-risk individuals to get screened for lung cancer. The goal is to increase awareness and motivate people to undergo screening. By targeting those at higher risk, the intervention aims to catch lung cancer early when it is more treatable.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment LungTalk for increasing lung cancer screening?

The research suggests that tools and interventions that enhance shared decision-making, like the Risk-Based NLST Outcomes Tool and decision aids, can improve patient understanding and decision-making about lung cancer screening. These findings imply that similar tools, such as LungTalk, may also be effective in increasing lung cancer screening by facilitating better communication and informed decision-making. ^{1 2 3 4 5}

How is the LungTalk treatment different from other lung cancer screening methods?

LungTalk is unique because it uses a digital communication tool to increase awareness and knowledge about lung cancer screening, leveraging social media to reach high-risk individuals who may not be aware of or have access to traditional screening methods. ^{1 6 7 8 9}

Research Team

Lisa Carter-Bawa, PhD

Principal Investigator

Hackensack Meridian Health

Eligibility Criteria

The INSPIRE-Lung Study is for individuals who have a history of heavy smoking (at least 20 pack-years), including current smokers or those who quit within the last 15 years. It's not for people who've already had lung cancer screening, are being monitored for lung nodules, have been diagnosed with lung cancer, or have impaired decision-making.

Inclusion Criteria

You have smoked an average of one pack a day for 20 years or more.

I am a current smoker or quit smoking within the last 15 years.

Exclusion Criteria

I am capable of making my own decisions.

I have had a low-dose CT scan for lung cancer and am being monitored for lung nodules.

I have been diagnosed with lung cancer.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants receive either the tailored health communication intervention 'LungTalk' or the non-tailored ACS Lung Screening Informational Video

6 months

Online intervention

Follow-up

Participants are monitored for effectiveness of the intervention, including self-efficacy, perceived risk, and screening uptake

6 months

Long-term Monitoring

Reaching screening eligible individuals via social media and measuring engagement metrics

Up to 4 years

Treatment Details

Interventions

• LungTalk
• Non-tailored intervention - Standard of practice

Trial Overview This study tests 'LungTalk', a communication intervention aimed at increasing lung cancer screening rates among high-risk groups using Facebook-targeted advertisements. It compares LungTalk to standard practices without tailored interventions.

Participant Groups

Group I: Tailored health communication intervention (LungTalk) Experimental Treatment 1 Intervention

Participants will receive the tailored health intervention "LungTalk". LungTalk is a 10-15 minute long computer-tailored health communication and decision-making tool that is theoretically grounded in the Conceptual Model on Lung Cancer Screening Participation.

Group II: Non-tailored Intervention Active Control 1 Intervention

Participants will receive non-tailored American Cancer Society (ACS) Lung Screening Informational Video as per standard of care. ACS Lung Screening Informational Video (ACS LSIV) is a non-tailored 5-minute video from the American Cancer Society about lung cancer screening designed for the lay individual.

LungTalk is already approved in United States for the following indications:

Approved in United States as LungTalk for:

• Lung Cancer Screening Awareness
• Education and Support

Who Is Running the Clinical Trial?

Hackensack Meridian Health

Lead Sponsor

Trials

141

Recruited

42,900+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+

Findings from Research

The Risk-Based NLST Outcomes Tool (RNOT) helps individuals understand their personalized risk of lung cancer diagnosis and death, which can aid in making informed decisions about screening.

Participants in the study found the RNOT useful for screening decisions, although they expressed confusion about risk changes and indicated that there was no level of false-positive risk that would deter them from screening.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Patient Perspectives on the Risk-Based NLST Outcomes Tool for Lung Cancer Screening. Roberts, MC., Seaman, EL., Klein, WMP., et al.[2022]

A group education class on lung cancer screening significantly improved participants' knowledge, with an average increase of 0.9 correct responses on a true-false quiz after the class, based on surveys from 680 participants.

Approximately 70% of participants felt they had enough information to make informed decisions about lung cancer screening after attending the class, indicating that this educational approach effectively enhances decision-making capacity.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation. Sakoda, LC., Meyer, MA., Chawla, N., et al.[2021]

The study aims to implement a tailored approach to shared decision-making (SDM) for lung cancer screening (LCS) within the VA New England Health Care Network, addressing barriers at multiple levels to enhance patient-centered care.

By evaluating the effectiveness of this multilevel implementation strategy, the research seeks to improve the quality of SDM for LCS, potentially informing nationwide practices and promoting better patient-provider interactions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Implementing Shared Decision-Making for Lung Cancer Screening across a Veterans Health Administration Hospital Network: A Hybrid Effectiveness-Implementation Study Protocol. Khanna, A., Fix, GM., McCullough, MB., et al.[2022]

A single-page, paper-based encounter decision aid (EDA) used during shared decision-making visits for lung cancer screening significantly reduced patient decisional conflict, as indicated by a drop in the Decisional Conflict Scale score from 35.0 to 0.2 (p < 0.001).

While 28% of patients understood the mortality benefit of lung cancer screening after the visit, a much higher percentage (82%) grasped the frequency of abnormal screening results, highlighting the need for improved patient education on the mortality benefits of screening.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Pilot Study of an Encounter Decision Aid for Lung Cancer Screening. Ito Fukunaga, M., Balwan, A., Janis, JA., et al.[2023]

A systematic review of 24 studies involving 6689 patients found that only 57% adhered to Lung-RADS-recommended screening intervals, indicating suboptimal compliance that could reduce the effectiveness of lung cancer screening.

Adherence rates were significantly higher for patients with Lung-RADS scores of 3 to 4 compared to those with scores of 1 to 2, suggesting that patients with more concerning findings are more likely to follow up with screenings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Patient Adherence to Lung CT Screening Reporting & Data System-Recommended Screening Intervals in the United States: A Systematic Review and Meta-Analysis. Lin, Y., Fu, M., Ding, R., et al.[2022]

A randomized controlled trial is being conducted to evaluate the effectiveness of a social media-based intervention called LungTalk, aimed at increasing awareness and knowledge about lung cancer screening among high-risk individuals.

The study addresses the low uptake of lung cancer screening despite evidence from the National Lung Screening Trial showing that low-dose computed tomography can reduce lung cancer mortality, highlighting the potential of social media to reach underserved populations.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Leveraging social media to increase lung cancer screening awareness, knowledge and uptake among high-risk populations (The INSPIRE-Lung Study): Study protocol of design and methods of a community-based randomized controlled trial. Lisa, CB., Banerjee, SC., Ostroff, JS., et al.[2023]

The Lung AIR intervention effectively increased knowledge and reduced fear about lung cancer screening among 292 participants, demonstrating its feasibility as a community-based educational program.

One-on-one phone sessions were particularly effective, leading to greater increases in participants' intention to complete screening compared to in-person group sessions, especially among those with lower income and higher smoking rates.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adapting Community Educational Programs During the COVID-19 Pandemic: Comparing the Feasibility and Efficacy of a Lung Cancer Screening Educational Intervention by Mode of Delivery. Bouchard, EG., Saad-Harfouche, FG., Clark, N., et al.[2023]

A randomized trial involving 298 Maryland Tobacco Quitline callers showed that providing lung cancer screening (LCS) education through print materials led to higher engagement (75% read the materials) compared to web-based materials (61.6%).

Despite similar rates of scheduling or completing LCS between the two groups (around 43%), the study highlights that offering educational materials in preferred formats (print or web) can enhance awareness and potentially increase screening rates among eligible individuals.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The tobacco quitline setting as a teachable moment: The Educating Quitline Users About Lung (EQUAL) cancer screening randomized trial. Webster, M., Whealan, J., Williams, RM., et al.[2023]

A focus group study involving 54 participants from Appalachian Kentucky revealed that most individuals were previously unaware of lung cancer screening with low-dose computed tomography (LDCT), highlighting the need for effective awareness campaigns.

Participants emphasized the importance of messaging that includes personal testimonies, hope, and the benefits of early detection, suggesting that communication from trusted healthcare providers is crucial for promoting lung cancer screening.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Identifying Community Perspectives for a Lung Cancer Screening Awareness Campaign in Appalachia Kentucky: The Terminate Lung Cancer (TLC) Study. Cardarelli, R., Roper, KL., Cardarelli, K., et al.[2018]

References

1. England pubmed.ncbi.nlm.nih.gov

Patient Perspectives on the Risk-Based NLST Outcomes Tool for Lung Cancer Screening. [2022]

2. England pubmed.ncbi.nlm.nih.gov

Effectiveness of a Patient Education Class to Enhance Knowledge about Lung Cancer Screening: a Quality Improvement Evaluation. [2021]

3. United States pubmed.ncbi.nlm.nih.gov

Implementing Shared Decision-Making for Lung Cancer Screening across a Veterans Health Administration Hospital Network: A Hybrid Effectiveness-Implementation Study Protocol. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Pilot Study of an Encounter Decision Aid for Lung Cancer Screening. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

Patient Adherence to Lung CT Screening Reporting & Data System-Recommended Screening Intervals in the United States: A Systematic Review and Meta-Analysis. [2022]

6. United States pubmed.ncbi.nlm.nih.gov

Leveraging social media to increase lung cancer screening awareness, knowledge and uptake among high-risk populations (The INSPIRE-Lung Study): Study protocol of design and methods of a community-based randomized controlled trial. [2023]

7. England pubmed.ncbi.nlm.nih.gov

Adapting Community Educational Programs During the COVID-19 Pandemic: Comparing the Feasibility and Efficacy of a Lung Cancer Screening Educational Intervention by Mode of Delivery. [2023]

8. England pubmed.ncbi.nlm.nih.gov

The tobacco quitline setting as a teachable moment: The Educating Quitline Users About Lung (EQUAL) cancer screening randomized trial. [2023]

9. England pubmed.ncbi.nlm.nih.gov

Identifying Community Perspectives for a Lung Cancer Screening Awareness Campaign in Appalachia Kentucky: The Terminate Lung Cancer (TLC) Study. [2018]