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Contingency Management for Cocaine Use Disorder (WRAP Trial)

N/A
Waitlist Available
Led By Sarah E. Forster, PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Normal or Corrected-to-Normal Vision
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 month post-treatment interval
Awards & highlights

WRAP Trial Summary

This trial will investigate how changes in brain signaling and cognitive functioning can help people recovering from addiction, as well as using pretreatment neurocognitive functioning to Substance use disorders are prevalent, especially among Veterans, and cocaine addiction in particular has been shown to complicate treatment of other high priority behavioral health problems in the Veteran population. Contingency Management, a behavioral intervention for cocaine users, can be effective, but individual responses are variable and long-term benefits are limited. This trial will test a new model of how CM works by examining brain-based predictors and indicators of treatment response, with the goal of immediate implications for measurement-based implementation of existing CM

Who is the study for?
This trial is for military veterans who have used cocaine in the past 60 days and meet criteria for Cocaine Use Disorder. They must want to stop or reduce cocaine use, have good vision and hearing (with aids if needed). It's not open to those with severe cognitive issues, pregnant or breastfeeding women, people with certain neurological conditions, or unstable health.Check my eligibility
What is being tested?
The study tests how a behavioral intervention called Contingency Management helps recovery from cocaine addiction by rewarding abstinence. It also looks at brain signaling and cognitive function changes during treatment. The goal is to tailor this approach to each veteran's needs.See study design
What are the potential side effects?
Since the interventions involve behavioral therapy rather than medication, typical medical side effects are not expected. However, participants may experience stress or emotional discomfort when discussing substance use or due to the demands of adhering to treatment protocols.

WRAP Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My vision is normal, or corrected to normal with glasses or contacts.

WRAP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 month post-treatment interval
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 month post-treatment interval for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
% Cocaine-Negative Urine Specimens
Longest Duration of Cocaine Abstinence
Secondary outcome measures
% Contingency Management (CM) Sessions Attended (CM Groups Only)
% Self-Reported Cocaine-Abstinent Days During Treatment
% Self-Reported Drug- and Alcohol-Abstinent Days During Treatment
+3 more
Other outcome measures
Pre- to Post-Treatment Change Spontaneous Eyeblink Rate
Pre- to Post-Treatment Change in Episodic Future Thinking Effect (Delay Discounting)
Pre- to Post-Treatment Change in Executive Working Memory
+1 more

WRAP Trial Design

2Treatment groups
Experimental Treatment
Group I: Voucher Prize-Based Contingency Management (VoucherPBCM)Experimental Treatment2 Interventions
For participants assigned to VoucherPBCM, prize draws resulting in one or more small, large, or jumbo wins will be reinforced with VA Canteen vouchers in the specified incentive range (i.e., small, large, or jumbo).
Group II: Tangible Prize-Based Contingency Management (TangiblePBCM)Experimental Treatment2 Interventions
For participants assigned to TangiblePBCM, prize draws resulting in one or more small, large, or jumbo wins will result in access to a prize cabinet stocked with small, medium, large, and jumbo financial incentive items. Medium incentive items are included for selection in the event that a patient draws several small prize slips on the same day and are considered equivalent to 4 small prizes. Selection of specific prize items will be informed by patient preference and items will be restocked at least every 2 weeks. The prize cabinet will be open during TangiblePBCM sessions such that prize items are readily visible. Selection of prizes, maintenance of the prize cabinet, and policies regarding prize redemption will follow published guidance on administration of TangiblePBCM within the context of research protocols.

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,605 Previous Clinical Trials
3,305,537 Total Patients Enrolled
Sarah E. Forster, PhDPrincipal InvestigatorVA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Media Library

Prize-Based Contingency Management Clinical Trial Eligibility Overview. Trial Name: NCT03799341 — N/A
Cocaine Use Disorder Research Study Groups: Voucher Prize-Based Contingency Management (VoucherPBCM), Tangible Prize-Based Contingency Management (TangiblePBCM)
Cocaine Use Disorder Clinical Trial 2023: Prize-Based Contingency Management Highlights & Side Effects. Trial Name: NCT03799341 — N/A
Prize-Based Contingency Management 2023 Treatment Timeline for Medical Study. Trial Name: NCT03799341 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being recruited for participation in this experiment?

"Indeed, clinicaltrials.gov indicates that this medical research is currently recruiting patients. The study was first published on November 13th 2019 and the details were last modified on November 14th 2022. It seeks to enrol 180 participants at one specific location."

Answered by AI

Am I eligible to join the research project?

"This clinical trial seeks to enroll 180 individuals with cocaine use disorder, aged 18-75. To be eligible for the study, applicants must meet certain criteria including being a Military Veteran and meeting DSM-5 Criteria Cocaine Use Disorder (Mild, Moderate or Severe), having consumed cocaine within 60 days of application, expressing an intent to reduce or abstain from further consumption of the substance as well as possessing normal vision and hearing abilities - corrected if necessary."

Answered by AI

Does this trial offer inclusion to those aged 25 and above?

"This medical trial is currently seeking participants who are aged between 18 and 75."

Answered by AI

Are there any available slots left in this research initiative?

"According to the clinicaltrials.gov website, this medical trial is presently searching for participants and has been since it was initially posted on November 13th 2019. The details of the study have also been revised as recently as November 14th 2022."

Answered by AI

What objectives is this clinical trial striving to fulfill?

"The 12-week Treatment Interval of this trial primarily aims to assess the Longest Duration of Cocaine Abstinence. Measurable secondary objectives include Total Non-CM Treatment Encounters (Number of non-CM treatment encounters during treatment), % Self-Reported Cocaine Abstinent Days During Treatment (Proportion of self-reported cocaine abstinent days) and % Self Reported Drug and Alcohol Abstinent Days During Treatment (Proportion of self reported drug and alcohol abstainent days)."

Answered by AI
~11 spots leftby Mar 2025