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Behavioral Intervention

CPT + Memory Enhancement for PTSD

Waitlist Available
Led By James C. Scott, PhD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up through study completion, weeks 12-16 of treatment
Awards & highlights


This trial examines ways to help older adults with PTSD learn and remember the psychotherapy they receive, with the goal of improving their outcomes.

Who is the study for?
This trial is for veterans over the age of 59 with PTSD diagnosed by a specific scale (CAPS-5). It's not suitable for those with severe brain injury, dementia signs, daily benzodiazepine use, bipolar or psychotic disorders, current serious suicidal thoughts, active substance abuse issues not in remission for at least a month, or other limiting conditions.Check my eligibility
What is being tested?
The study tests whether adding Memory Support to Cognitive Processing Therapy (CPT) can help older adults with PTSD learn and remember therapy content better. The goal is to improve how well they respond to treatment.See study design
What are the potential side effects?
Since this trial involves psychotherapy rather than medication, side effects may include emotional discomfort due to discussing traumatic events during therapy sessions. Physical side effects are unlikely.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, weeks 12-16 of treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, weeks 12-16 of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
PTSD Checklist-5 (PCL-5)
Other outcome measures
Client Satisfaction Questionnaire (CSQ)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Processing Therapy (CPT) + Memory SupportExperimental Treatment2 Interventions
CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.
Group II: Cognitive Processing Therapy (CPT)Active Control1 Intervention
Standard CPT as described in the treatment manual
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Processing Therapy

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,628 Previous Clinical Trials
3,325,949 Total Patients Enrolled
James C. Scott, PhDPrincipal InvestigatorCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
1 Previous Clinical Trials
139 Total Patients Enrolled
~20 spots leftby Sep 2025