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mRNA Vaccine

mRNA Flu Vaccine for Flu

Verified Trial
Phase 1 & 2
Waitlist Available
Research Sponsored by Sanofi Pasteur, a Sanofi Company
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
You are at least 18 years old
Answer yes if you have *not* received a Flu Vaccine within the last six (6) months
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1, day 91, day 181 and day 366
Awards & highlights

Study Summary

This trial tests the safety and effectiveness of a new flu vaccine in adults 18+ compared to existing vaccines.

Who is the study for?
This trial is for adults 18 years and older who haven't had a flu shot in the last six months. Participants must be able to attend up to eight study visits over one year.Check my eligibility
What is being tested?
The trial tests a new Quadrivalent Influenza mRNA Vaccine MRT5410 against three other flu vaccines: high dose, standard dose, and recombinant versions. It involves one injection and compares safety and immune response.See study design
What are the potential side effects?
Potential side effects may include pain at the injection site, fatigue, headache, muscle pain, feverish feelings or chills which are common with flu vaccines.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
Select...
Have you not received a flu vaccine in the last six months? If yes, then you meet this criterion.
Select...
You are available to come to the study site for up to 8 visits within a year.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1, day 91, day 181 and day 366
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1, day 91, day 181 and day 366 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Individual HAI titer ratio
Individual Hemagglutination inhibition (HAI) titer
Number of participants archiving HAI seroconversion against Antigens
+8 more
Secondary outcome measures
Individual HAI Ab titer ratio
Individual antibodies HAI titer ratio
Individual neutralizing antibodies titer ratio
+3 more

Side effects data

From 2012 Phase 3 trial • 6104 Patients • NCT01346592
27%
Injection site pain
25%
Pyrexia
14%
Upper respiratory tract infection
14%
Decreased appetite
14%
Diarrhea
10%
Injection site erythema
9%
Nasopharyngitis
9%
Irritability postvaccinal
9%
Headache
8%
Vomiting
8%
Injection site induration
7%
Hypersomnia
7%
Myalgia
7%
Injection site swelling
7%
Fatigue
6%
Crying
6%
Injection site hemorrhage
4%
Gastroenteritis
1%
Pneumonia
1%
Animal Bite
100%
80%
60%
40%
20%
0%
Study treatment Arm
ATIV (6 to <72 Months)
TIV (6 to <72 Months)
Comparator TIV (6 to <72 Months)

Trial Design

6Treatment groups
Experimental Treatment
Active Control
Group I: Group 3: Quadrivalent Influenza mRNA Vaccine MRT5410 high doseExperimental Treatment1 Intervention
participants will receive a single dose (high) of QIV mRNA vaccine
Group II: Group 2: Quadrivalent Influenza mRNA Vaccine MRT5410 medium doseExperimental Treatment1 Intervention
participants will receive a single dose (medium) of QIV mRNA vaccine
Group III: Group 1: Quadrivalent Influenza mRNA Vaccine MRT5410 low doseExperimental Treatment1 Intervention
participants will receive a single dose (low) of QIV mRNA vaccine
Group IV: Group 4: RIV4Active Control1 Intervention
participants will receive a single dose of RIV4 vaccine
Group V: Group 5: QIV-SDActive Control1 Intervention
participants will receive a single dose of QIV-SD vaccine
Group VI: Group 6: QIV-HDActive Control1 Intervention
participants will receive a single dose of QIV -HD vaccine

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Sanofi Pasteur, a Sanofi CompanyLead Sponsor
404 Previous Clinical Trials
6,056,865 Total Patients Enrolled
Clinical Sciences & OperationsStudy DirectorSanofi
857 Previous Clinical Trials
2,018,273 Total Patients Enrolled

Media Library

Quadrivalent Influenza mRNA Vaccine MRT5410 (mRNA Vaccine) Clinical Trial Eligibility Overview. Trial Name: NCT05624606 — Phase 1 & 2
Flu Shot Research Study Groups: Group 4: RIV4, Group 1: Quadrivalent Influenza mRNA Vaccine MRT5410 low dose, Group 5: QIV-SD, Group 2: Quadrivalent Influenza mRNA Vaccine MRT5410 medium dose, Group 6: QIV-HD, Group 3: Quadrivalent Influenza mRNA Vaccine MRT5410 high dose
Flu Shot Clinical Trial 2023: Quadrivalent Influenza mRNA Vaccine MRT5410 Highlights & Side Effects. Trial Name: NCT05624606 — Phase 1 & 2
Quadrivalent Influenza mRNA Vaccine MRT5410 (mRNA Vaccine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05624606 — Phase 1 & 2
Flu Shot Patient Testimony for trial: Trial Name: NCT05624606 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current participation rate for this trial?

"Affirmative. Data found on clinicaltrials.gov demonstrates that this medical trial, which launched on November 28th 2022 is currently recruiting patients from 1 medical site with a target of 690 participants."

Answered by AI

Are there currently any open spots for this research trial?

"Clinicaltrials.gov reveals that this medical experiment, initially published on November 28th 2022 and recently amended on the 30th of the same month, is seeking volunteers."

Answered by AI

Who else is applying?

What state do they live in?
Idaho
Florida
Other
Texas
What site did they apply to?
Florida International Research Center-Site Number:8400009
Joint Clinical Trials Huntington Park-Site Number:8400032
Other
Elligo Health Research
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
2
3+
1
0

Why did patients apply to this trial?

Saw study on FB. For the compensate. I’ve never joined a study. I almost died with the flu.
PatientReceived 2+ prior treatments
Interested in clinical trials!
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How long are visits? How long are screening visits? If I don't qualify, can you please let me know the reason?
PatientReceived no prior treatments
What do I have to do to complete this trial/survey to get compensated?
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Phone Call
Average response time
  • < 2 Days
Most responsive sites:
  1. Elligo Health Research: < 48 hours
~292 spots leftby Mar 2025