Troriluzole for Obsessive-Compulsive Disorder
Recruiting at 56 trial locations
Age: 18+
Sex: Any
Trial Phase: Phase 2 & 3
Sponsor: Biohaven Pharmaceuticals, Inc.
Stay on Your Current MedsYou can continue your current medications while participating
Prior Safety DataThis treatment has passed at least one previous human trial
Trial Summary
What is the purpose of this trial?
This trial is testing troriluzole to see if it can help people with OCD who haven't improved with common medications. Troriluzole works by balancing brain chemicals that may be causing OCD symptoms. The goal is to find a more effective treatment for those who need additional help.
Eligibility Criteria
This trial is for adults with Obsessive Compulsive Disorder (OCD) who haven't had enough improvement from certain medications like SSRIs or clomipramine. Participants must be medically stable, able to perform tests and interviews, understand English well, and agree to use two forms of contraception if applicable. They should have moderate to severe OCD symptoms despite current treatment but no other major psychiatric conditions that could affect their OCD assessment.Inclusion Criteria
My current medication for OCD isn't working well, and my symptoms are severe.
I have at least 6 years of education and am fluent in English.
My health is stable based on recent exams and tests.
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Exclusion Criteria
Mini Mental State Examination (MMSE) score of < 24 at Screening
I do not have any mental or physical health conditions that could explain my OCD symptoms.
I have tried at least 3 different depression medications without success.
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Treatment Details
Interventions
- BHV-4157
- Placebo
Trial OverviewThe study is testing the effectiveness of troriluzole as an additional treatment compared to a placebo in people with OCD who don’t respond well enough to standard treatments. Troriluzole's benefits will be evaluated alongside participants' ongoing medication regimens.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: TroriluzoleExperimental Treatment1 Intervention
Group II: PlaceboPlacebo Group1 Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
Biohaven Pharmaceuticals, Inc.
Lead Sponsor
Trials
49
Recruited
30,100+
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