Cooling/Compression Therapy for Chemotherapy-Induced Peripheral Neuropathy
(ICE COMPRESS Trial)
Trial Summary
What is the purpose of this trial?
This trial tests three methods to prevent nerve damage in patients receiving taxane chemotherapy. The methods involve using special wraps that either cool the limbs, apply steady pressure, or apply gentle pressure that comes and goes. These approaches aim to protect nerves from the harmful effects of chemotherapy drugs. Cooling the limbs has been well-tolerated and is a reasonable option to prevent nerve damage in patients receiving taxane-based treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Cooling/Compression Therapy for Chemotherapy-Induced Peripheral Neuropathy?
Research suggests that cryocompression therapy, which combines cooling and compression, may help prevent chemotherapy-induced peripheral neuropathy (nerve damage from cancer treatment). Studies have shown that cryocompression can achieve lower skin temperatures safely and may be more effective than other cooling methods like frozen gloves.12345
Is cooling/compression therapy safe for humans?
How is cryocompression therapy different from other treatments for chemotherapy-induced peripheral neuropathy?
Cryocompression therapy combines cooling and compression to prevent chemotherapy-induced peripheral neuropathy, offering a unique approach that may improve efficacy and safety compared to traditional methods like frozen gloves, which can cause cold intolerance and frostbite. This treatment provides thermoregulated cooling with dynamic pressure, potentially allowing for lower temperatures with better tolerance and effectiveness.12345
Research Team
Melissa K Accordino
Principal Investigator
SWOG - Columbia University
Katherine Pennington, MD
Principal Investigator
NRG - University of Washington
Eligibility Criteria
This trial is for adults with solid tumor cancers starting specific chemotherapy within 3 days. They must be able to complete questionnaires in English or Spanish, consent to the study, and agree to provide specimen samples. Excluded are those with skin/limb metastases, prior neurotoxic chemo, open limb wounds, existing neuropathy, or certain cold-related disorders.Inclusion Criteria
Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo cryocompression, continuous compression, or low cyclic compression during taxane chemotherapy infusions
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Cryocompression Therapy (Behavioural Intervention)
- Pneumatic Compression Therapy (Behavioural Intervention)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Southwest Oncology Group
Lead Sponsor
SWOG Cancer Research Network
Lead Sponsor
National Cancer Institute (NCI)
Collaborator