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Ketone Ester Supplement

Ketone Esters for Obesity and Insulin Resistance

N/A

Waitlist Available

Led By Austin J Graybeal, PhD

Research Sponsored by University of Southern Mississippi

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion

Awards & highlights

Study Summary

This trial tests if a ketone supplement can reduce appetite and improve cognition, metabolism & cardiovascular function for those with obesity & insulin resistance.

Who is the study for?

This trial is for adults aged 18-50 with obesity and insulin resistance, which could include prediabetes or type 2 diabetes not requiring insulin. Participants should have a BMI of at least 30 kg/m2, waist circumference over 102 cm for males or over 88 cm for females, or high body fat percentage. It's not open to those who are pregnant/breastfeeding, have type I diabetes, recent surgeries affecting digestion, severe brain injuries in the last two years, liver/kidney/thyroid diseases, metal implants/pacemakers/electrical implants.Check my eligibility

What is being tested?

Researchers are testing if an oral ketone ester supplement can reduce appetite and improve cognition compared to a placebo in individuals with obesity and insulin resistance. They will also examine its effects on metabolism and cardiovascular function. The study includes both people with normal weight/no insulin resistance and those affected by these conditions.See study design

What are the potential side effects?

While specific side effects aren't listed here, supplements like ketone esters may cause digestive discomforts such as nausea or stomach upset. As this is a controlled trial setting any unexpected reactions would be closely monitored.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 30, 45, 60, 75, 90, 105, 120 minutes post ingestion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Blood pressure

Cardiac Baroreflex Sensitivity

Desire to eat - Visual Digital Analog Scale (0-100)

+11 more

Secondary outcome measures

Blood glucose

Blood ketones

Carbon Dioxide Produced from Respiratory Gases

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Ketone EsterExperimental Treatment1 Intervention

Oral ketone ester supplement

Group II: PlaceboPlacebo Group1 Intervention

Taste and viscosity matched placebo

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of Southern MississippiLead Sponsor

13 Previous Clinical Trials

2,895 Total Patients Enrolled

1 Trials studying Metabolic Syndrome

200 Patients Enrolled for Metabolic Syndrome

Austin J Graybeal, PhDPrincipal InvestigatorUniversity of Southern Mississippi

1 Previous Clinical Trials

200 Total Patients Enrolled

1 Trials studying Metabolic Syndrome

200 Patients Enrolled for Metabolic Syndrome

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are applicants above eighty-five years of age being considered for this trial?

"This trial is seeking participants of ages 18-50 years."

Answered by AI

What are the eligibility requirements for participation in this research?

"The criteria for enrolment in this medical clinical trial is impaired glucose tolerance and an age bracket between 18-50. Approximately 30 individuals are anticipated to join the study."

Answered by AI

Are there openings left in this scientific experiment?

"Affirmative. According to the clinicaltrials.gov records, this study is presently recruiting applicants and was initially posted on December 20th 2022. The most recent update occurred on December 6th of that same year, with 30 patient slots available at a single centre."

Answered by AI

How many individuals are partaking in this research endeavor?

"Affirmative. The clinical trial is open to new participants based on the data hosted on clinicaltrials.gov, which states that it was first posted in December 20th 2022 and last edited 6 days later. 30 individuals have been invited to join the study at one medical centre."

Answered by AI

What aims does this medical experiment seek to accomplish?

"The primary evaluation metric of this trial, measured over a defined period post ingestion, is Thirst - Visual Digital Analog Scale (0-100). Supporting metrics include Prefrontal Cortex Oxygenation as indicated by Near-infrared spectroscopy, Peripheral Vascular Conductance estimated through Blood flow normalized to blood pressure readings (mL/min/mmHg), and finally capillary Blood glucose levels."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance

Austin Graybeal 2022. "Ketone Esters for Appetite, Cognition, and Cardiovascular Function in Individuals With Obesity and Insulin Resistance". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05651243.