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High-fat Meal Challenge for Insulin Resistance

N/A
Waitlist Available
Research Sponsored by Dartmouth-Hitchcock Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up five blood draws (fasting, 30 minutes, 60 minutes, 120 minutes, and 180 minutes) all completed on 1 day
Awards & highlights

Study Summary

This trial will test how well children can metabolize a high-fat meal after exercising, to see if it affects their insulin resistance.

Who is the study for?
This trial is for children aged 8-17 with obesity, specifically those who are heavier than at least 5% of kids their age. They must be able to do a treadmill test and not take meds that affect blood sugar levels. Kids with inherited fat metabolism issues, allergies to certain fats or proteins in the meal challenge, or diagnosed diabetes can't join.Check my eligibility
What is being tested?
The study looks at how fit kids handle a high-fat meal. Fitness is checked on a treadmill and then researchers see how well their bodies break down the fat by looking at different markers in the blood related to health and insulin resistance.See study design
What are the potential side effects?
Since this trial involves eating a high-fat meal and exercising on a treadmill, side effects might include stomach discomfort or nausea from the meal, as well as typical exercise-related fatigue or muscle soreness.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~five blood draws (fasting, 30 minutes, 60 minutes, 120 minutes, and 180 minutes) all completed on 1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and five blood draws (fasting, 30 minutes, 60 minutes, 120 minutes, and 180 minutes) all completed on 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Determine if the interaction between daily physical activity and dietary intake mediates the correlation between VO2 max and body composition - as measured by VO2 max.
Determine if the interaction between daily physical activity and dietary intake mediates the correlation between VO2 max and body composition - as measured by body composition.
Determine if the interaction between daily physical activity and dietary intake mediates the correlation between VO2 max and body composition - as measured by daily dietary intake.
+1 more
Secondary outcome measures
Assess the correlation between fatty acid oxidation and VO2 max.
Other outcome measures
Assess if fatty acid oxidation mediates the correlation between VO2 max and a continuous metabolic syndrome score.

Trial Design

1Treatment groups
Experimental Treatment
Group I: High-fat Metabolic ChallengeExperimental Treatment1 Intervention
Participants will consume a high-fat agent one time, at the second study visit.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
High-fat Challenge
2022
N/A
~20

Find a Location

Who is running the clinical trial?

Dartmouth-Hitchcock Medical CenterLead Sponsor
524 Previous Clinical Trials
2,543,326 Total Patients Enrolled

Media Library

High-fat Challenge Clinical Trial Eligibility Overview. Trial Name: NCT05230433 — N/A
Childhood Obesity Research Study Groups: High-fat Metabolic Challenge
Childhood Obesity Clinical Trial 2023: High-fat Challenge Highlights & Side Effects. Trial Name: NCT05230433 — N/A
High-fat Challenge 2023 Treatment Timeline for Medical Study. Trial Name: NCT05230433 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are new participants still sought to join this experiment?

"According to the information on clinicaltrials.gov, this trial has already finished its recruitment phase and is no longer looking for patients; it was first posted on May 1st 2022, with the most recent update being published September 19th 2022. Nonetheless, there are still 318 other trials open which require participants right now."

Answered by AI

What criteria must one satisfy to partake in this scientific experiment?

"To qualify for this research, participants must present with insulin resistance and be between 8-17 years of age. Currently, the team is recruiting 50 individuals."

Answered by AI

Is this study open to participants over the age of forty?

"The age range for participants accepted into this trial is 8 to 17 years old, as specified in the inclusion criteria."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
High-fat Meal Challenge in Pediatrics
Jennifer L. Meijer 2022. "High-fat Meal Challenge in Pediatrics". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05230433.
~5 spots leftby Apr 2025
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