Study Summary
This trial will investigate the effect of lorcaserin on the brain's control of appetite and metabolism.
Eligible Conditions
- Obesity
- Weight Loss
Treatment Effectiveness
Effectiveness Progress
This is further along than 93% of similar trials
Study Objectives
1 Primary · 2 Secondary · Reporting Duration: 6 months
28 days
fMRI (Functional changes in the brain)
6 months
Body Composition (DEXA)
Metabolic Rate (Resting Metabolic Rate (RMR)
Trial Safety
Safety Progress
This is further along than 85% of similar trials
Trial Design
2 Treatment Groups
Active
1 of 2
Placebo
1 of 2
Active Control
Non-Treatment Group
40 Total Participants · 2 Treatment Groups
Primary Treatment: Active · Has Placebo Group · Phase 4
Placebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: DrugActive
Drug
ActiveComparator Group · 1 Intervention: Lorcaserin HCl · Intervention Types: DrugTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months
Who is running the clinical trial?
Beth Israel Deaconess Medical CenterLead Sponsor
777 Previous Clinical Trials
844,340 Total Patients Enrolled
20 Trials studying Obesity
590 Patients Enrolled for Obesity
Christos S Mantzoros, MD DScPrincipal InvestigatorBeth Israel Deaconess Medical Center
Eligibility Criteria
Age 18 - 65 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:References
- Farr, Olivia M., Jagriti Upadhyay, Anna Gavrieli, Michelle Camp, Nikolaos Spyrou, Harper Kaye, Hannah Mathew, et al.. 2016. “Lorcaserin Administration Decreases Activation of Brain Centers in Response to Food Cues and These Emotion- and Salience-related Changes Correlate with Weight Loss Effects: A 4-week-long Randomized, Placebo-controlled, Double-blind Clinical Trial”. Diabetes. American Diabetes Association. doi:10.2337/db16-0635.
- Christos Mantzoros 2014. "Lorcaserin in Obesity: Identification of CNS Targets Using fMRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02400359.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Conditions
Cancer Related
Treatments