Ketone Supplements for Ketosis
(STAK-VKM Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies how different ages and overall health affect the body's response to a special drink. Participants will consume the drink, and researchers will measure how their bodies process it by checking blood and urine levels.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it requires that you maintain your medication habits throughout the study. If your medication use is unstable and might affect the trial outcomes, you may be excluded from participating.
Is it safe for humans to consume ketone supplements?
How is the ketone supplement treatment different from other treatments for ketosis?
The ketone supplement, specifically bis hexanoyl (R)-1,3-butanediol, is unique because it induces ketosis without requiring dietary changes, unlike traditional methods that rely on high-fat, low-carbohydrate diets. It is available in novel forms like powder and ready-to-drink beverages, which rapidly increase blood ketone levels, making it a convenient option for achieving nutritional ketosis.13467
What data supports the effectiveness of the treatment Ketone Supplements for Ketosis?
Research shows that ketone supplements, like the ones used in the trial, can safely increase blood ketone levels, which is a state known as ketosis. This state has been associated with potential benefits for physical and cognitive performance, making ketone supplements a practical way to achieve ketosis without dietary changes.12348
Who Is on the Research Team?
Jeff Volek, PhD
Principal Investigator
Ohio State University
Are You a Good Fit for This Trial?
This trial is for individuals aged 20-70 who can fast, avoid alcohol and exercise before testing, and maintain consistent diet and medication habits. They must not have health issues that could affect study participation or interpretation of results as determined by the Investigator.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Testing
Participants undergo a series of tests including dietary assessment, body composition measurement, and a submaximal exercise test to determine eligibility and baseline metrics.
Test Day
Participants consume the C8 Ketone Diester Study Product and undergo blood and urine sampling to assess ketone metabolism and tolerability.
Follow-up
Participants are monitored for any adverse effects and overall health status after the test day.
What Are the Treatments Tested in This Trial?
Interventions
- Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale
- Blood Draw
- Ketone Supplement
- Urine Analysis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
Buck Institute for Research on Aging
Collaborator