Radiation Therapy for Non-Hodgkin's Lymphoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies a new radiation therapy for treating non-Hodgkin's lymphoma (a type of blood cancer) in patients who didn't fully respond to previous CAR T-cell therapy. The goal is to determine if this treatment is safe and can help more patients achieve complete remission (no signs of cancer) by targeting specific cancer sites. This trial is open to those diagnosed with high-grade non-Hodgkin’s lymphoma who have undergone CAR T-cell therapy but still show signs of cancer. As a Phase 1 trial, this research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this new therapy.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
What prior data suggests that this radiation therapy is safe for non-Hodgkin's lymphoma patients?
Research has shown that radiation therapy is generally safe for people with non-Hodgkin's lymphoma. One study found that using radiation therapy before CAR T-cell therapy was both safe and effective. Most patients achieved excellent local control, meaning the cancer remained controlled where the radiation was applied. Another study found that radiation therapy alone yielded good results for non-Hodgkin's lymphoma patients. Although radiation can cause side effects, these studies suggest it is well-tolerated in similar situations.12345
Why are researchers excited about this trial?
Unlike the standard treatments for Non-Hodgkin's Lymphoma, which often include chemotherapy, immunotherapy, or whole-body radiation, this investigational approach involves focal radiation therapy. This treatment is unique because it targets only the residual FDG-avid sites, as identified by PET/CT scans, rather than the entire body. This precision means that it can potentially minimize side effects and focus on areas that are still active after initial treatments. Researchers are excited because this method could offer a more tailored treatment option, especially for patients with specific symptomatic or bulky lesions.
What evidence suggests that focal radiation therapy is effective for relapsed/refractory non-Hodgkin's lymphoma?
Research has shown that radiation therapy can help treat non-Hodgkin's lymphoma (NHL). Studies have found that adding radiation therapy to treatment plans for diffuse large B-cell lymphoma, a type of NHL, can lead to better outcomes. In this trial, all participants will receive focal radiation therapy, which targets specific areas of the disease, at all residual FDG-avid sites. This approach may increase the chances of a full response in patients who haven't fully responded to other treatments, such as CAR T-cell therapy. Overall, evidence suggests that radiation therapy can be a beneficial addition for managing NHL that has returned or is not responding to other treatments.13678
Who Is on the Research Team?
Kiran Kumar, MD
Principal Investigator
University of Texas Southwestern Medical Center
Are You a Good Fit for This Trial?
Adults over 18 with certain types of non-Hodgkin lymphoma who didn't fully respond to previous CAR T-cell therapy can join. They must be in relatively good health, understand the study, and agree to use birth control. People with brain involvement by cancer, severe side effects from prior treatments, very short life expectancy or conditions that could limit following the trial rules cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation Therapy
Participants receive focal radiation therapy to all residual FDG-avid sites as noted on day 30 post-CAR-T PET/CT scan
Follow-up
Participants are monitored for safety and effectiveness after radiation therapy, including assessment of metabolic complete response at day 90 post-CAR-T PET/CT
What Are the Treatments Tested in This Trial?
Interventions
- Focal radiation therapy (RT)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Texas Southwestern Medical Center
Lead Sponsor