A strategy of first choice endotracheal intubation for Cardiac Arrest

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Montefiore Medical Center, New York, NY
Cardiac Arrest+3 More
A strategy of first choice endotracheal intubation - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The Hospital Airway Resuscitation Trial (HART) is a cluster-randomized, pragmatic trial of advanced airway management with a strategy of first choice supraglottic airway vs. first choice endotracheal intubation during in-hospital cardiac arrest.

Eligible Conditions

  • Cardiac Arrest
  • Respiratory Failure

Treatment Effectiveness

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: From cardiac arrest until 72 hours after cardiac arrest

Day 60
Survival to hospital discharge
Day 7
Rate of ventilator-associated pneumonia (VAP)
From cardiac arrest until 28-days after cardiac arrest
Alive-and-ventilator free days
Hour 72
72-hour survival
From start of chest compressions during cardiac arrest until ROSC or death up to 24-hours
Chest compression fraction
First pass airway success rate
Prolonged pauses
Hour 24
Return of spontaneous circulation (ROSC)

Trial Safety

Trial Design

2 Treatment Groups

First choice endotracheal intubation, Then First choice supraglottic airway
1 of 2
First choice supraglottic airway device, Then First choice endotracheal intubati...
1 of 2
Active Control
Experimental Treatment

1060 Total Participants · 2 Treatment Groups

Primary Treatment: A strategy of first choice endotracheal intubation · No Placebo Group · N/A

First choice supraglottic airway device, Then First choice endotracheal intubationExperimental Group · 2 Interventions: A strategy of first choice endotracheal intubation, A strategy of first choice supraglottic airway · Intervention Types: Procedure, Procedure
First choice endotracheal intubation, Then First choice supraglottic airwayActiveComparator Group · 2 Interventions: A strategy of first choice endotracheal intubation, A strategy of first choice supraglottic airway · Intervention Types: Procedure, Procedure

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: from cardiac arrest until 72 hours after cardiac arrest
Closest Location: Montefiore Medical Center · New York, NY
Photo of montefiore medical center 1Photo of montefiore medical center 2Photo of montefiore medical center 3
2019First Recorded Clinical Trial
1 TrialsResearching Cardiac Arrest
651 CompletedClinical Trials

Who is running the clinical trial?

Montefiore Medical CenterLead Sponsor
403 Previous Clinical Trials
552,432 Total Patients Enrolled
Ari Moskowitz, MDPrincipal InvestigatorMontefiore Medical Center
1 Previous Clinical Trials
88 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have lost your pulse and your chest compressions are not being delivered for ≥2 minutes.
You are in need of assisted ventilation.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.