← Back to Search

Laser Therapy

Fractional CO2 Laser for Burn Scars

N/A

Recruiting

Led By Jonathan Friedstat, MD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patient must already be planning to undergo laser treatment for their burn scar

Patient must be willing to undergo biopsy procedures

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 7 months

Awards & highlights

Study Summary

This trial aims to understand why laser treatment reduces pain & itch associated with hypertrophic burn scars.

Who is the study for?

This trial is for individuals with hypertrophic burn scars that are painful, itchy, or hypersensitive. Participants must have had the burn within the last two years and be planning to undergo laser treatment. They should agree to biopsies and a year of follow-up. Pregnant individuals or those on certain medications like steroids, antihistamines, pain relief drugs, or those affecting wound healing cannot join.Check my eligibility

What is being tested?

The study tests how effective Fractional CO2 laser therapy (Luminis ultrapulse) is in reducing pain and itchiness in hypertrophic burn scars. It involves histological evaluations over different stages of treatment to understand the underlying mechanisms behind symptom improvement.See study design

What are the potential side effects?

Potential side effects may include discomfort at the site of laser application, skin redness, swelling, changes in skin pigmentation, scarring from biopsies taken during the study process and possible allergic reactions to topical or local anesthetics used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am planning to have laser treatment for my burn scar.

Select...

I am willing to have biopsy procedures.

Select...

My burn injury happened within the last 2 years.

Select...

I have a thickened burn scar treated with skin grafts or healed on its own.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 7 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~7 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Histological change in nerve density

Histological change in nerve morphology

Secondary outcome measures

Symptomatic Improvement Assessment

Trial Design

1Treatment groups

Experimental Treatment

Group I: TreatmentExperimental Treatment1 Intervention

Laser treatment to 3x3cm2 area. It will receive the Luminous ultra pulse fractional ablative carbon dioxide laser at 150mJ, 3% density and 250Hz

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,941 Previous Clinical Trials

13,200,641 Total Patients Enrolled

Jonathan Friedstat, MDPrincipal InvestigatorMassachusetts General Hospital

1 Previous Clinical Trials

120 Total Patients Enrolled

Media Library

Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser (Laser Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04364217 — N/A

Hypertrophic Scar Research Study Groups: Treatment

Hypertrophic Scar Clinical Trial 2023: Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser Highlights & Side Effects. Trial Name: NCT04364217 — N/A

Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser (Laser Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04364217 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any age restrictions for inclusion into this experiment?

"The eligibility criteria for this trial permits individuals over 18 and under 80 years to be enrolled."

Answered by AI

How many individuals are receiving treatment as part of this experiment?

"Affirmative. Clinicaltrials.gov contains information that this research is currently on the lookout for participants, which was initially posted on June 25th 2020 and updated most recently on February 28th 2023. A total of 28 individuals need to be sourced from a single location."

Answered by AI

Do I satisfy the criteria to partake in this medical study?

"This clinical trial seeks 28 individuals with hypertrophic scars aged between 18 to 80 for participation. Specific requirements include having symptoms of pain, itchiness, or hypersensitivity; already planning laser treatment for the scarring; burn scar must be treated by skin grafts or accelerated healing process and willing to go through biopsy procedures."

Answered by AI

Is the process of enrollment for this clinical trial still open?

"Per clinicaltrials.gov, this experiment is presently looking for participants. It was first introduced on June 25th 2020 and the latest update occurred February 28th 2023."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser

Jonathan Friedstat 2020. "Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04364217.

All > Scar