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Laser Therapy

Fractional CO2 Laser for Burn Scars

N/A
Recruiting
Led By Jonathan Friedstat, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patient must already be planning to undergo laser treatment for their burn scar
Patient must be willing to undergo biopsy procedures
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 months
Awards & highlights

Study Summary

This trial aims to understand why laser treatment reduces pain & itch associated with hypertrophic burn scars.

Who is the study for?
This trial is for individuals with hypertrophic burn scars that are painful, itchy, or hypersensitive. Participants must have had the burn within the last two years and be planning to undergo laser treatment. They should agree to biopsies and a year of follow-up. Pregnant individuals or those on certain medications like steroids, antihistamines, pain relief drugs, or those affecting wound healing cannot join.Check my eligibility
What is being tested?
The study tests how effective Fractional CO2 laser therapy (Luminis ultrapulse) is in reducing pain and itchiness in hypertrophic burn scars. It involves histological evaluations over different stages of treatment to understand the underlying mechanisms behind symptom improvement.See study design
What are the potential side effects?
Potential side effects may include discomfort at the site of laser application, skin redness, swelling, changes in skin pigmentation, scarring from biopsies taken during the study process and possible allergic reactions to topical or local anesthetics used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am planning to have laser treatment for my burn scar.
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I am willing to have biopsy procedures.
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My burn injury happened within the last 2 years.
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I have a thickened burn scar treated with skin grafts or healed on its own.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Histological change in nerve density
Histological change in nerve morphology
Secondary outcome measures
Symptomatic Improvement Assessment

Trial Design

1Treatment groups
Experimental Treatment
Group I: TreatmentExperimental Treatment1 Intervention
Laser treatment to 3x3cm2 area. It will receive the Luminous ultra pulse fractional ablative carbon dioxide laser at 150mJ, 3% density and 250Hz

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,327 Total Patients Enrolled
Jonathan Friedstat, MDPrincipal InvestigatorMassachusetts General Hospital
1 Previous Clinical Trials
120 Total Patients Enrolled

Media Library

Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser (Laser Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04364217 — N/A
Hypertrophic Scar Research Study Groups: Treatment
Hypertrophic Scar Clinical Trial 2023: Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser Highlights & Side Effects. Trial Name: NCT04364217 — N/A
Luminis Ultrapulse Fractional Ablative Carbon Dioxide Laser (Laser Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04364217 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any age restrictions for inclusion into this experiment?

"The eligibility criteria for this trial permits individuals over 18 and under 80 years to be enrolled."

Answered by AI

How many individuals are receiving treatment as part of this experiment?

"Affirmative. Clinicaltrials.gov contains information that this research is currently on the lookout for participants, which was initially posted on June 25th 2020 and updated most recently on February 28th 2023. A total of 28 individuals need to be sourced from a single location."

Answered by AI

Do I satisfy the criteria to partake in this medical study?

"This clinical trial seeks 28 individuals with hypertrophic scars aged between 18 to 80 for participation. Specific requirements include having symptoms of pain, itchiness, or hypersensitivity; already planning laser treatment for the scarring; burn scar must be treated by skin grafts or accelerated healing process and willing to go through biopsy procedures."

Answered by AI

Is the process of enrollment for this clinical trial still open?

"Per clinicaltrials.gov, this experiment is presently looking for participants. It was first introduced on June 25th 2020 and the latest update occurred February 28th 2023."

Answered by AI
~5 spots leftby Mar 2025