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Phototherapy for Depression

Waitlist Available
Research Sponsored by University of Ottawa
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
First episode of depression before age 25
Be younger than 65 years old
Must not have
Use of medications that may interact with light to produce a photoallergic reaction
Screening 3 weeks
Treatment Varies
Follow Up score between baseline and follow up (8 weeks)
Awards & highlights


This trial will help to clarify the mechanisms underlying the antidepressant effects of phototherapy and will provide valuable information about the potential role of sleep in the antidepressant response to bright light therapy.

Who is the study for?
This trial is for young people with depression who have had their first episode before age 25 and are currently seeking treatment. They must have a certain score on a depression scale to join. People can't participate if they've taken certain medications recently, have other major psychiatric disorders, work night shifts, travel across time zones often, abuse substances, or have conditions that react badly to light.Check my eligibility
What is being tested?
The study tests whether special glasses emitting phototherapy light can improve symptoms of depression in young individuals by altering their sleep-wake cycle. It explores the idea that those with delayed sleep patterns may benefit more from this therapy.See study design
What are the potential side effects?
Potential side effects include eye strain or discomfort and skin reactions due to bright light exposure. However, these effects are generally mild and not common.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
My first depression episode was before I turned 25.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
I am not taking any medications that react badly to light.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~score between baseline and follow up (8 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and score between baseline and follow up (8 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Associations between Changes in Sleep-Wake Profile and Changes in Severity of Depression
Associations between Initial Sleep-Wake Profile and Changes in Severity of Depression
Fatigue Severity
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: PhototherapyExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

University of SydneyOTHER
193 Previous Clinical Trials
315,267 Total Patients Enrolled
5 Trials studying Depression
1,125 Patients Enrolled for Depression
University of OttawaLead Sponsor
210 Previous Clinical Trials
268,129 Total Patients Enrolled
11 Trials studying Depression
1,441 Patients Enrolled for Depression

Media Library

Phototherapy (Other) Clinical Trial Eligibility Overview. Trial Name: NCT02448433 — N/A
Depression Research Study Groups: Phototherapy
Depression Clinical Trial 2023: Phototherapy Highlights & Side Effects. Trial Name: NCT02448433 — N/A
Phototherapy (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02448433 — N/A
~6 spots leftby Jul 2025