Aortic Stenosis Clinical Trials
Here are the 6 most popular medical studies for aortic stenosis
Device
Electrophysiology-Guided Care for Left Bundle Branch Block After TAVI
This trial will compare an electrophysiology-based algorithm to standard clinical follow-up in patients who have had TAVI and new left bundle branch block. The goal is to see if the electrophysiology-based algorithm can reduce syncope, hospitalization, and death.
Transcatheter Valve Replacement
TAVR vs SAVR for Aortic Valve Stenosis
This trial is comparing the safety and effectiveness of the Medtronic TAVR system to SAVR in the treatment of severe aortic stenosis in low risk patients. The continued access phase will be single-arm and non-randomized.
Procedure
Septal Scoring Along Midline Endocardium for Aortic Valve Stenosis
"This trial is testing a new procedure called SESAME in adults with a condition where the heart's pumping chambers are separated by a thick wall. This thick wall can cause reduced blood flow and serious heart disease
Popular filter options for aortic stenosis trials
AS Clinical Trials
View 26 AS medical studies.
Transcatheter Aortic Valve Replacement
Aortic Valve Replacement for Aortic Stenosis
This trial is comparing two types of aortic valve replacement surgery in people with a small aortic annulus and severe native aortic stenosis. Additionally, there is a sub-study that will be conducted at select sites evaluating the performance of the two types of surgery after exercise stress echocardiographic testing.
Aortic Valve Stenosis Clinical Trials
View 24 Aortic Valve Stenosis medical studies.
ECG Monitoring Device
ECG Monitoring for Aortic Stenosis
This trial is looking at whether arrhythmias are more common in people with aortic stenosis who are candidates for TAVI. If so, then detecting and treating these arrhythmias before the TAVI procedure may improve patient outcomes.
Transcatheter Aortic Valve Replacement (TAVR)
TAVR with CENTERA THV for Aortic Stenosis
This trial will test the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with severe aortic valve stenosis who are at intermediate risk for surgical aortic valve replacement (SAVR).
Transcatheter Valve Replacement
SAPIEN 3 Ultra System for Aortic Stenosis
This trial will show how safe and effective the SAPIEN 3 Ultra System is for people with severe aortic valve disease who are at an intermediate risk for standard aortic valve replacement.
Aortic Stenosis Clinical Trials With No Placebo
View 48 aortic stenosis medical studies that do not have a placebo group.
ECG Monitoring Device
ECG Monitoring for Aortic Stenosis
This trial is looking at whether arrhythmias are more common in people with aortic stenosis who are candidates for TAVI. If so, then detecting and treating these arrhythmias before the TAVI procedure may improve patient outcomes.
Transcatheter Aortic Valve Replacement (TAVR)
TAVR with CENTERA THV for Aortic Stenosis
This trial will test the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with severe aortic valve stenosis who are at intermediate risk for surgical aortic valve replacement (SAVR).
Transcatheter Valve Replacement
SAPIEN 3 Ultra System for Aortic Stenosis
This trial will show how safe and effective the SAPIEN 3 Ultra System is for people with severe aortic valve disease who are at an intermediate risk for standard aortic valve replacement.
View More Aortic Stenosis Trials
See another 28 medical studies focused on aortic stenosis.
Frequently Asked Questions
Introduction to aortic stenosis
What are the top hospitals conducting aortic stenosis research?
When it comes to pioneering clinical trials in the field of aortic stenosis, several top hospitals are leading the way. Lankenau Medical Center, located in Wynnewood, Pennsylvania, is at the forefront with its six ongoing trials focused on this condition and a commendable history of eight previous trials. The hospital's dedication to aortic stenosis research began in 2010 when they recorded their first ever trial for this cardiovascular disorder. Meanwhile, across the country in Los Angeles, Cedars-Sinai Medical Center is also making significant strides with five active trials and an impressive total of twenty completed studies dedicated to understanding and treating aortic stenosis since their inaugural trial back in 2010.
In Wichita, Kansas, the Cardiovascular Research Institute has emerged as another key player in advancing our knowledge of aortic stenosis. With five active clinical trials currently underway and eight previously conducted investigations under their belt since 2014 when they embarked on their first trial related to this condition; its contribution towards further comprehending and managing this ailment has been quite impactful given relatively recent involvement compared to other institutions.
The renowned Mayo Clinic located in Rochester takes pride not only as one of the most respected medical facilities but also as an important contributor toward better outcomes for those affected by aortic stenosis. Their commitment shines through with five ongoing clinical trials alongside sixteen successful past endeavors dating back to 2002 when they made their initial breakthroughs studying patients' response towards treatments associated with such disorders.
Finally joining these esteemed establishments is Vanderbilt University Medical Center situated within Nashville where there are four presently carried out researches providing invaluable insights into tackling Aortic Stenosis while contributing equally vital prior contributions through thirteen investigations that have taken place from recording earliest visualized experimentation regarding same cases dating approximately about ten years ago till now
These exceptional hospitals demonstrate not just expertise but also resilience required for pushing boundaries within medical science. By continuously striving to unravel the complexities of aortic stenosis through rigorous research, these institutions offer hope for improved treatments and enhanced quality of life for individuals living with this condition.
Which are the best cities for aortic stenosis clinical trials?
When it comes to aortic stenosis clinical trials, several cities emerge as leaders in research and development. New york, with 25 active trials, focuses on studying Medtronic CoreValve® System Transcatheter Aortic Valve Implantation (TAVI) and other innovative treatments. Houston follows closely behind with 16 ongoing studies exploring Medtronic Evolut PRO and other TAV systems. Los Angeles also plays a significant role in advancing aortic stenosis care with 15 active trials investigating SAPIEN 3 THV and optimal heart failure therapy. These cities offer individuals battling aortic stenosis access to cutting-edge clinical trials that drive advancements in treatment options and improve patient outcomes.
Which are the top treatments for aortic stenosis being explored in clinical trials?
In the realm of clinical trials for aortic stenosis, several top treatments have emerged as potential game-changers. Among these are:
- Doppler-echocardiography, currently being explored in one active trial and holding a track record of two all-time trials since its introduction in 2005.
- TAVR (Transcatheter Aortic Valve Replacement), making waves with one ongoing trial and an impressive total of eleven past studies dedicated to aortic stenosis since its debut in 2014.
- Medtronic Evolut PRO, Evolut PRO+ or Evolut FX TAV Systems (where commercially available), which is under investigation in one active trial and stands as the sole representative among past trials for this condition since its listing in 2021.
- Leaflex™ Performer, entering the scene more recently with one current trial but already boasting three all-time trials focusing on aortic stenosis after appearing on the radar in 2020. With each study conducted, progress inches forward toward finding innovative solutions for individuals affected by this challenging cardiovascular condition.
What are the most recent clinical trials for aortic stenosis?
Recent clinical trials have provided valuable insights into the treatment of aortic stenosis, a condition characterized by the narrowing of the aortic valve. One such study focused on DA-1229, a medication administered at 5mg dosage. This trial progressed through both Phase 2 and Phase 3, becoming available for participation as of June 27, 2022. Another investigation explored the potential benefits of using angiotensin receptor blockers to manage aortic stenosis in Phase 4 trials starting from February 1, 2020. These advancements in medical research present promising avenues for improving outcomes and quality of life for individuals affected by this cardiac condition.
What aortic stenosis clinical trials were recently completed?
Several recent clinical trials have made significant advancements in the field of aortic stenosis. Notably, there was a completed trial for transcatheter aortic valve replacement (TAVR) conducted by University Hospital Zurich, which concluded in September 2021. Another highly relevant study involved sotagliflozin and its potential impact on patients with aortic stenosis; this trial was sponsored by Sanofi-Aventis Deutschland GmbH and completed in August 2021. These trials represent important efforts to improve our understanding and treatment options for individuals affected by aortic stenosis.