100 Participants Needed

Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis

JL
SL
Overseen BySarah L Rabbitt, RN, BSN
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis. The aim is to demonstrate superior efficacy of platelet-rich plasma (PRP) as compared to hyaluronic acid (HA) in treating knee osteoarthritis. This aim will be objectively measured by endpoint consisting of changes in cartilage thickness from baseline in the MRI. The Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire will be used to calculate The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score. It will measure changes in pain and function from baseline. Approximately 100 subjects will be treated at NorthShore University HealthSystem (NorthShore) as part of this study. This study has the potential to improve outcomes in a very common chronic degenerative disease, osteoarthritis, which can have a significant effect on individuals' quality of life.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop all current medications, but you cannot use NSAIDs (non-steroidal anti-inflammatory drugs) 5 days before a blood draw or up to 7 days after the last PRP or HA treatment. It's best to discuss your specific medications with the trial team.

Is Platelet-Rich Plasma and Hyaluronic Acid treatment safe for humans?

In studies involving treatments for knee osteoarthritis, the most common side effects reported were high blood pressure and protein in the urine. These treatments are generally considered safe, but like any medical procedure, they can have side effects.12345

How does the treatment of platelet-rich plasma (PRP) and hyaluronic acid (HA) differ from other treatments for osteoarthritis?

Platelet-rich plasma (PRP) and hyaluronic acid (HA) are unique non-surgical treatments for osteoarthritis that involve injecting substances directly into the joint to provide relief. PRP uses a patient's own blood to create a concentration of platelets that release growth factors, while HA acts as a lubricant to improve joint movement. These treatments aim to delay the need for surgery and offer an alternative to standard pain relief methods.45678

What data supports the effectiveness of the treatment Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis?

Research shows that both platelet-rich plasma (PRP) and hyaluronic acid (HA) are effective for treating knee osteoarthritis, with PRP often providing better pain relief and functional improvement than HA. However, the combination of PRP and HA has shown mixed results, and more studies are needed to confirm its effectiveness.59101112

Who Is on the Research Team?

JL

Jason L Koh, MD, MBA

Principal Investigator

Clinical Chairman, Dept. of Orthopaedics

Are You a Good Fit for This Trial?

This trial is for adults aged 18-75 with chronic knee pain from osteoarthritis, graded 2-3 on the K-L scale. Participants must have had pain for over three months and score at least a 40 on the VAS for pain. They should be able to consent and pass a physical exam, blood tests including platelet count, CRP, and ESR.

Inclusion Criteria

I have a list of all medications I am currently taking.
Complete Blood Count to include platelets and differential (CBC with Diff) within normal limits
Physical exam and medical history
See 6 more

Exclusion Criteria

Immuno-suppression (e.g., AIDS, etc.)
Platelet counts (PLT) <150,000 /mm3
Pregnancy/Breastfeeding
See 17 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Treatment

Participants receive either PRP or HA injections for knee osteoarthritis treatment

12 months
Multiple visits for injections and assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 month
1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

  • HA Treatment
  • PRP Treatment
Trial Overview The study compares two treatments: PRP (platelet-rich plasma) and HA (hyaluronic acid), to see which is better at improving knee osteoarthritis symptoms. It's measured by MRI changes in cartilage thickness and improvements in pain/function via KOOS/WOMAC scores.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: PRP TreatmentExperimental Treatment1 Intervention
Group II: HA TreatmentActive Control1 Intervention

HA Treatment is already approved in United States, European Union, Canada for the following indications:

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Approved in United States as Hyaluronic Acid for:
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Approved in European Union as Hyaluronic Acid for:
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Approved in Canada as Hyaluronic Acid for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

Endeavor Health

Lead Sponsor

Trials
135
Recruited
742,000+

NorthShore University HealthSystem

Lead Sponsor

Trials
134
Recruited
740,000+

Published Research Related to This Trial

In a meta-analysis of 10 studies, intra-articular platelet-rich plasma (PRP) injections were found to be more effective than hyaluronic acid (HA) injections in reducing pain and improving functionality in patients with osteoarthritis, as measured by the IKDC, WOMAC, and VAS scores.
While PRP showed significant benefits over HA in pain relief and functional improvement, both treatments did not differ significantly in the Knee Osteoarthritis Outcome Scores (KOOS), suggesting that while PRP may provide better short-term outcomes, the overall impact on knee function as measured by KOOS may be similar.
Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection.Wu, Q., Luo, X., Xiong, Y., et al.[2020]
In a randomized controlled trial involving 111 patients with mild to moderate knee osteoarthritis, platelet-rich plasma (PRP) injections showed significant improvements in subjective knee evaluations compared to hyaluronic acid (HA) at 24 weeks and 52 weeks, despite no difference in the primary pain score measure.
The study suggests that the anti-inflammatory properties of PRP may contribute to symptom improvement, as indicated by trends in reduced proinflammatory cytokines, although the primary outcome measure (WOMAC pain score) did not show a significant difference between PRP and HA.
Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee OsteoarthritisCole, BJ., Karas, V., Hussey, K., et al.[2022]
A single intraarticular injection of plasma-rich platelet (PRP) combined with either Artz or HYAJOINT Plus significantly reduced knee pain and improved function in patients with knee osteoarthritis over a 6-month period, with no serious adverse events reported.
While both treatment combinations were effective, the PRP + HYAJOINT Plus group showed superior improvements in specific measures of function and stability, particularly in patients with more severe baseline symptoms.
Comparing efficacy of a single intraarticular injection of platelet-rich plasma (PRP) combined with different hyaluronans for knee osteoarthritis: a randomized-controlled clinical trial.Huang, HY., Hsu, CW., Lin, GC., et al.[2023]

Citations

Platelet-rich plasma versus hyaluronic acid in knee osteoarthritis: A meta-analysis with the consistent ratio of injection. [2020]
Hyaluronic Acid Versus Platelet-Rich Plasma: A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intra-articular Biology for the Treatment of Knee Osteoarthritis [2022]
Comparing efficacy of a single intraarticular injection of platelet-rich plasma (PRP) combined with different hyaluronans for knee osteoarthritis: a randomized-controlled clinical trial. [2023]
Comparative Analysis of the Effectiveness of Intra-Articular Injection of Platelet-Rich Plasma versus Hyaluronic Acid for Knee Osteoarthritis: Results of an Open-Label Trial. [2022]
Platelet-Rich Plasma Versus Hyaluronic Acid for Hip Osteoarthritis Yields Similarly Beneficial Short-Term Clinical Outcomes: A Systematic Review and Meta-analysis of Level I and II Randomized Controlled Trials. [2022]
Clinical therapy of hyaluronic acid combined with platelet-rich plasma for the treatment of knee osteoarthritis. [2020]
Intra-articular hyaluronic acid vs platelet-rich plasma in the treatment of hip osteoarthritis. [2022]
How to Choose Platelet-Rich Plasma or Hyaluronic Acid for the Treatment of Knee Osteoarthritis in Overweight or Obese Patients: A Meta-Analysis. [2020]
Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. [2022]
Hyaluronic acid induces the release of growth factors from platelet-rich plasma. [2022]
11.United Statespubmed.ncbi.nlm.nih.gov
Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. [2021]
Comparison of clinical efficiency between intra-articular injection of platelet-rich plasma and hyaluronic acid for osteoarthritis: a meta-analysis of randomized controlled trials. [2023]
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