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Viscosupplementation

PRP Treatment for Osteoarthritis

Phase 2
Recruiting
Led By Jason L Koh, MD, MBA
Research Sponsored by NorthShore University HealthSystem
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 to 75 years old
Chronic pain (>3 months)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks, 12 weeks, 6 months, and 12 months
Awards & highlights

Study Summary

This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.

Who is the study for?
This trial is for adults aged 18-75 with chronic knee pain from osteoarthritis, graded 2-3 on the K-L scale. Participants must have had pain for over three months and score at least a 40 on the VAS for pain. They should be able to consent and pass a physical exam, blood tests including platelet count, CRP, and ESR.Check my eligibility
What is being tested?
The study compares two treatments: PRP (platelet-rich plasma) and HA (hyaluronic acid), to see which is better at improving knee osteoarthritis symptoms. It's measured by MRI changes in cartilage thickness and improvements in pain/function via KOOS/WOMAC scores.See study design
What are the potential side effects?
Potential side effects of PRP or HA injections can include temporary increased joint pain or swelling, bleeding or bruising at the injection site, allergic reactions, or infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 75 years old.
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I have been experiencing pain for more than 3 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks, 12 weeks, 6 months, and 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks, 12 weeks, 6 months, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cartilage Thickness on MRI
Secondary outcome measures
3. A will be measuring changes in the KOOS Jr (Knee injury and Osteoarthritis Outcome Score)

Side effects data

From undefined Phase 3 trial • 332 Patients • NCT01240382
1%
Eye irritation
1%
Gastrointestinal bleeding
100%
80%
60%
40%
20%
0%
Study treatment Arm
0.1% HA
3% DE-089

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: PRP TreatmentExperimental Treatment1 Intervention
PRP is injected using 22 gauge needles through the classic approach (lateral midpatellar) in a sterile setting. The PRP is obtained from a maximum 16 cc sample of the patients' blood drawn at the time of treatment. Using sterile technique, the venous blood is transferred to a centrifuge and prepared by the centrifugation process for 5 minutes. 4-7 mL of PRP is transferred from the large outer syringe into the small inner syringe and injected within 30 minutes of being spun to negate the need of anticoagulants. The procedure will take approximately 20-30 minutes.
Group II: HA TreatmentActive Control1 Intervention
HA is injected using 22 gauge needles through the classic approach (lateral midpatellar) in a sterile setting. Euflexxa will be prepared according to the package insert.

Find a Location

Who is running the clinical trial?

NorthShore University HealthSystemLead Sponsor
132 Previous Clinical Trials
737,558 Total Patients Enrolled
2 Trials studying Osteoarthritis
405 Patients Enrolled for Osteoarthritis
Jason L Koh, MD, MBAPrincipal InvestigatorClinical Chairman, Dept. of Orthopaedics

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an age restriction for the recruitment of participants in this trial, specifically regarding individuals who are above 70 years old?

"To be deemed eligible for inclusion in this research, individuals must have reached the age of 18 but not exceed 70 years."

Answered by AI

Are new patients currently being accepted for enrollment in this medical study?

"At this moment, recruitment for this research has ceased. The trial was initially shared on June 13th, 2018 and last revised on August 20th, 2019. For those seeking alternative options, there are currently 674 ongoing studies seeking participants with osteoarthritis and an additional 6 trials specifically targeting PRP Treatment applicants."

Answered by AI

What is the total number of participants enrolled in this clinical trial?

"As of now, this particular research is not actively seeking participants. Originally shared on June 13th, 2018 and last revised on August 20th, 2019. For those interested in other opportunities, there are presently 674 trials open for individuals with osteoarthritis and six active studies focusing specifically on PRP Treatment that are accepting new candidates."

Answered by AI

What conditions are typically targeted for treatment with Platelet-Rich Plasma therapy?

"Fibrosis management frequently involves the application of Platelet-Rich Plasma (PRP) Therapy. This therapeutic approach is versatile and can effectively address various health issues such as conjunctivitis, knee discomfort, and anal fissures."

Answered by AI

What are the potential risks associated with Platelet-Rich Plasma therapy for individuals undergoing treatment?

"Based on our evaluation at Power, the safety rating for PRP Treatment is a 2. This assessment stems from it being classified as a Phase 2 trial, with existing data supporting safety but lacking evidence of efficacy."

Answered by AI

Are there any previous research investigations focusing on PRP therapy?

"At present, there are 6 ongoing research investigations focusing on Platelet-Rich Plasma (PRP) therapy, with 1 trial progressing to Phase 3. While a number of these trials are being conducted in San Francisco, California, PRP Treatment is also under scrutiny at 5 additional sites."

Answered by AI

Who else is applying?

What state do they live in?
Washington
Illinois
Maryland
Other
How old are they?
65+
18 - 65
What site did they apply to?
NorthShore University HealthSystems
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have tried physical therapy, cortisone shots, stretching, strengthening meloxicam, just to name a few treatments. They have not provided relief and my knee is getting worse and inhibiting my ability to even walk up and down stairs let alone play better tennis and run. I’ve been diagnosed as needing a full knee replacement but I want to try every possible natural way of healing without surgery. Surgery is my last resort and I want to see if this will provide relief.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How many injection sessions are given?
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis
Jason Koh 2018. "Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03491761.
All > Osteoarthritis > Knee Osteoarthritis
~21 spots leftby Dec 2025
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