32 Participants Needed

Energy Drink Effects on Blood Pressure and Heart Rate

RM
AM
Overseen ByAlison Mancera, BS
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas at Arlington

Trial Summary

Do I need to stop taking my current medications for the trial?

If you are taking any prescription medications that affect blood vessels (vasoactive medications), you cannot participate in the trial. Otherwise, the protocol does not specify if you need to stop other medications.

What data supports the effectiveness of the treatment Energy Drink on blood pressure and heart rate?

Research shows that energy drinks, which often contain caffeine and taurine, can increase blood pressure and heart rate. One study found that energy drinks significantly increased systolic blood pressure compared to a placebo.12345

Are energy drinks safe for blood pressure and heart rate?

Research shows that energy drinks can increase blood pressure and heart rate. They have been linked to more emergency room visits and can cause cardiovascular side effects, so caution is advised.12678

How does the energy drink treatment affect blood pressure and heart rate compared to other treatments?

Energy drinks are unique in their combination of caffeine and sugar, which can increase blood pressure and heart rate through different pathways compared to caffeine alone. Unlike other treatments, energy drinks may also contain additional ingredients like taurine, which could contribute to their cardiovascular effects.12689

What is the purpose of this trial?

The objective of this protocol is to investigate the effect of consumption of a commercially available energy drink beverage on blood pressure, heart rate, and energy metabolism

Research Team

RM

Robert M Brothers, PhD

Principal Investigator

University of Texas at Arlington

Eligibility Criteria

This trial is for individuals who are interested in understanding how energy drinks affect their blood pressure, heart rate, and metabolism. Specific eligibility criteria were not provided.

Inclusion Criteria

I do not have any heart, lung, or metabolic diseases.
Must be fasted
Must be caffeine naïve

Exclusion Criteria

Breastfeeding women
I have a heart, lung, metabolic, or brain disorder.
Food allergies
See 3 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 week

Treatment

Participants consume a 12 oz energy drink or water, and measurements are taken at baseline and at 30, 60, 90, and 120 minutes post-consumption

1 day
1 visit (in-person)

Follow-up

Participants are monitored for any delayed effects after beverage consumption

1 week

Treatment Details

Interventions

  • Energy Drink
  • Water Control
Trial Overview The study aims to compare the effects of an energy drink versus water on mean arterial pressure (MAP), heart rate (HR), and energy metabolism in participants.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Energy DrinkExperimental Treatment1 Intervention
A commercially available caffeine drink containing 200 mgs of caffeine.
Group II: WaterPlacebo Group1 Intervention
This will be 12 fl oz of commercially available water .

Energy Drink is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:

🇪🇺
Approved in European Union as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness
🇺🇸
Approved in United States as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness
🇨🇦
Approved in Canada as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness
🇯🇵
Approved in Japan as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness
🇨🇳
Approved in China as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness
🇨🇭
Approved in Switzerland as Energy Drink for:
  • General Health and Wellness
  • Physical Performance Enhancement
  • Mental Alertness

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas at Arlington

Lead Sponsor

Trials
48
Recruited
7,300+

Findings from Research

In a study involving 15 recreational runners, consumption of energy drinks led to a significant increase in systolic blood pressure compared to a placebo, indicating potential cardiovascular risks associated with energy drink consumption.
Despite the increase in blood pressure, the energy drinks did not show any performance benefits in terms of oxygen consumption (V[Combining Dot Above]O2) or perceived exertion (RPE) during exercise trials.
Effects of Energy Drinks on Economy and Cardiovascular Measures.Peveler, WW., Sanders, GJ., Marczinski, CA., et al.[2018]
Red Bull significantly increases blood pressure and heart rate compared to a placebo, with effects primarily due to its unique hemodynamic pathways rather than just caffeine or sugar content.
While both Red Bull and a comparable amount of caffeine raise blood pressure similarly, Red Bull affects cardiac parameters more, whereas caffeine primarily influences vascular resistance.
The blood pressure-elevating effect of Red Bull energy drink is mimicked by caffeine but through different hemodynamic pathways.Miles-Chan, JL., Charrière, N., Grasser, EK., et al.[2018]
In a study of 35 healthy young adults, consuming an energy drink containing caffeine and taurine led to significant improvements in both left and right ventricular function, as measured by echocardiographic parameters.
The results indicated a positive inotropic effect, with notable increases in left ventricular twisting (+22%) and right ventricular function parameters like TAPSE (+15%), suggesting that these substances may enhance heart performance acutely.
Acute effects of an energy drink on myocardial function assessed by conventional echo-Doppler analysis and by speckle tracking echocardiography on young healthy subjects.Menci, D., Righini, FM., Cameli, M., et al.[2021]

References

Effects of Energy Drinks on Economy and Cardiovascular Measures. [2018]
The blood pressure-elevating effect of Red Bull energy drink is mimicked by caffeine but through different hemodynamic pathways. [2018]
Acute effects of an energy drink on myocardial function assessed by conventional echo-Doppler analysis and by speckle tracking echocardiography on young healthy subjects. [2021]
Energy drinks: effects on pediatric 24-h ambulatory blood pressure monitoring. A randomized trial. [2023]
Supplementary effect of carbohydrate-electrolyte drink on sports performance, lactate removal & cardiovascular response of athletes. [2013]
Impact of Acute Energy Drink Consumption on Blood Pressure Parameters: A Meta-analysis. [2018]
Impact of High Volume Energy Drink Consumption on Electrocardiographic and Blood Pressure Parameters: A Randomized Trial. [2021]
Energy Drink Effects on Hemodynamics and Endothelial Function in Young Adults. [2021]
Energy Drinks and Their Impact on the Cardiovascular System: Potential Mechanisms. [2023]
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