MCI-active for Mild Cognitive Impairment

Baylor College of Medicine, Houston, TX
Mild Cognitive ImpairmentN- acetylcysteine plus Glycine v Placebo (alanine) - DietarySupplement
55 - 85
All Sexes

Study Summary

This trial will investigate whether glutathione (GSH) precursors N-acetylcysteine and glycine can help improve cognition in humans with mild cognitive impairment.

Eligible Conditions
  • Mild Cognitive Impairment

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Change between 0-weeks and 12-weeks

Change between 0-weeks and 12-weeks
Concentrations of Glutathione, cysteine, glycine, glutamic acid
Concentrations of malondialdehyde, F2,F3 isoprostanes
Endothelial function
Endothelial function markers sICAM, sVCAM, E-selectin
Mitochondrial fuel oxidation in fasted and fed states

Trial Safety

Phase-Based Safety

1 of 3

Trial Design

2 Treatment Groups

1 of 2
1 of 2

Active Control

Non-Treatment Group

60 Total Participants · 2 Treatment Groups

Primary Treatment: MCI-active · Has Placebo Group · Phase < 1

MCI-activeActiveComparator Group · 3 Interventions: N- acetylcysteine plus Glycine v Placebo (alanine), N-acetylcysteine (NAC), Glycine · Intervention Types: DietarySupplement, DietarySupplement, DietarySupplement
MCI-placeboPlaceboComparator Group · 2 Interventions: N- acetylcysteine plus Glycine v Placebo (alanine), Alanine · Intervention Types: DietarySupplement, DietarySupplement

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: change between 0-weeks and 12-weeks

Who is running the clinical trial?

The Methodist Hospital Research InstituteOTHER
243 Previous Clinical Trials
75,481 Total Patients Enrolled
Baylor College of MedicineLead Sponsor
946 Previous Clinical Trials
5,980,241 Total Patients Enrolled

Eligibility Criteria

Age 55 - 85 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have mild cognitive impairment.

Frequently Asked Questions

Is this investigation recruiting individuals aged 35 and over?

"According to the inclusion criteria, only those aged between 55 and 85 are eligible for this trial. In comparison, there are 24 studies that accept participants below 18 years of age, while 533 trials encompass people over 65." - Anonymous Online Contributor

Unverified Answer

To which demographic does this research opportunity extend?

"To be considered for admission to this trial, applicants must have mild cognitive impairment and fall between the ages of 55 and 85. Approximately 60 participants will ultimately be selected." - Anonymous Online Contributor

Unverified Answer

Is there availability to participate in this medical trial?

"Affirmative. According to, this research endeavor is actively recruiting participants since April 14th 2018 and was last updated on January 28th 2022. 60 individuals are needed from one medical centre for the trial's completion." - Anonymous Online Contributor

Unverified Answer

How many individuals are partaking in this experiment?

"Affirmative. states that this trial is actively recruiting, having been originally posted on April 14th 2018 and last updated January 28th 2022. In total 60 patients are necessary from 1 site to fulfil the requirements of the study." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.