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Proton Beam Therapy

Proton radiation for Gliomas

N/A
Waitlist Available
Led By Helen A Shih, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 years
Awards & highlights

Study Summary

"This trial is studying proton radiation to see if it can effectively treat brain tumors with fewer side effects compared to traditional radiation therapy."

Who is the study for?
This trial is for people with specific brain tumors called low-grade gliomas or Grade III anaplastic glioma, which have certain genetic features. Participants must need radiation therapy, be expected to live more than 5 years, speak English, and be able to undergo MRI scans and cognitive tests.Check my eligibility
What is being tested?
The study is testing proton radiation therapy to see if it can control tumor growth as effectively as photon therapy while reducing side effects. Proton radiation aims to spare healthy tissue from exposure unlike conventional therapies.See study design
What are the potential side effects?
While the goal of proton radiation is fewer side effects compared to traditional treatments, potential risks may include skin reactions at the treatment site, fatigue, headaches, hair loss near treated areas and temporary swelling.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Efficacy
Secondary outcome measures
Overall survival
Safety and Tolerability

Trial Design

1Treatment groups
Experimental Treatment
Group I: Proton radiation therapyExperimental Treatment1 Intervention
Single arm study delivering fractionated proton therapy over 6 week (54-59.4 Gy(RBE))
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Proton radiation
2011
Completed Phase 2
~20

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,932,260 Total Patients Enrolled
5 Trials studying Gliomas
292 Patients Enrolled for Gliomas
Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,292 Total Patients Enrolled
Helen A Shih, MDPrincipal InvestigatorMassachusetts General Hospital
3 Previous Clinical Trials
204 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Proton Radiation Therapy for Gliomas
Helen A. Shih, MD 2011. "Proton Radiation Therapy for Gliomas". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01358058.
~4 spots leftby May 2025
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