LY3841136 for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing a new drug called LY3841136 to see if it is safe and well-tolerated. It involves healthy and overweight participants. Blood tests will be used to measure how much of the drug gets into the bloodstream and how long it takes for the body to get rid of it.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you have diabetes or chronic conditions involving the heart, liver, or kidneys, you may not be eligible to participate.
How does the drug LY3841136 differ from other obesity treatments?
LY3841136 is a novel treatment for obesity, potentially offering a unique mechanism of action or combination of ingredients compared to existing options like liraglutide, which is a GLP-1 receptor agonist used for weight loss. While specific details about LY3841136 are not provided, it may differ in its administration route, dosage, or schedule, setting it apart from current treatments.12345
What data supports the effectiveness of the drug LY3841136 for obesity?
Research on similar drugs, like LY3437943, shows that targeting multiple receptors can help with weight loss and improve metabolic health. In studies, LY3437943 helped reduce body weight in obese mice and showed promise in early human trials, suggesting that LY3841136 might have similar benefits.678910
Who Is on the Research Team?
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Principal Investigator
Eli Lilly and Company
Are You a Good Fit for This Trial?
This trial is for healthy or overweight males and non-childbearing potential females with a stable weight. Participants must have a BMI of 18.5-32 kg/m² (Part A) or 27-40 kg/m² (Part B). They should agree to use contraception. Those with diabetes, lactating women, allergies to LY3841136 components, significant heart/liver/kidney diseases, severe allergies, or drug hypersensitivity cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment Part A
Participants receive single ascending doses of LY3841136 or placebo administered subcutaneously
Treatment Part B
Participants receive multiple ascending doses of LY3841136 or placebo administered subcutaneously
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- LY3841136
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Eli Lilly and Company
Lead Sponsor
Dr. Daniel Skovronsky
Eli Lilly and Company
Chief Medical Officer since 2018
MD from Harvard Medical School
David A. Ricks
Eli Lilly and Company
Chief Executive Officer since 2017
BSc from Purdue University, MBA from Indiana University