This trial studies niraparib before surgery in treating patients with localized high risk prostate cancer with alterations in DNA repair pathways.
- Prostate Cancer
- FANCL Gene Mutation
- BRCA1 Gene Mutation
- ATM Gene Mutation
- DNA Repair Gene Mutation
- GEN1 Gene Mutation
- CHEK1 Gene Mutation
- BRIP1 Gene Mutation
- CHEK2 Gene Mutation
- RAD51C Gene Mutation
- BRCA2 Gene Mutation
- Fanconi Anemia
- Nijmegen Breakage Syndrome
- CDK12 Gene Mutation
- DNA Damage Response Gene Mutation
- RAD51 Gene Mutation
- FANCD2 Gene Mutation
1 Primary · 1 Secondary · Reporting Duration: Up to 5 years
Awards & Highlights
1 Treatment Group
1 of 1
30 Total Participants · 1 Treatment Group
Primary Treatment: Niraparib · No Placebo Group · Phase 2
Who is running the clinical trial?
Age 18+ · Male Participants · 3 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
Frequently Asked Questions
What makes this research so innovative?
"Myriad Genetics, Inc. first ran a clinical trial for Niraparib in 2016. This study completed Phase 3 and 733 people participated across 49 countries in 476 cities. 28 more trials have been conducted since then." - Anonymous Online Contributor
What is the Niraparib research landscape?
"There are a total of 96 clinical trials currently underway to research Niraparib. 13 of those studies are in the final Phase 3 stage. The majority of these pharmaceutical trials take place in Washington, D.C., but there 2645 different locations around the world conducting similar research." - Anonymous Online Contributor
To what extent does Niraparib pose a threat to people?
"There is some data supporting Niraparib's safety, but none yet attesting to its efficacy. For this reason, it received a score of 2." - Anonymous Online Contributor
Are we still enrolling patients in this experiment?
"That is correct. The clinical trial in question, which was posted on February 25th 2020 and updated October 27th 2020, appears to be actively recruiting patients according to the data available on clinicaltrials.gov. They are currently looking for 30 participants at 1 location." - Anonymous Online Contributor
How many people are allowed to participate in this research project at one time?
"That is correct. The website clinicaltrials.gov has updated information regarding this study, which was first posted on February 25th 2020 and last updated October 27th 2020. Currently, the trial is enrolling 30 patients from 1 site." - Anonymous Online Contributor