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Apple vs Cranberry Juice for UTI Prevention in Healthy Women

N/A
Recruiting
Led By Liwei Gu, PhD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy women participants;
Healthy women participants
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to 21 days of each intervention
Awards & highlights

Study Summary

This trial found that some women who drink cranberry juice are less likely to get UTIs, but they don't know why. It could be because of the way the body processes the juice, which varies from person to person.

Who is the study for?
This trial is for healthy women with a Body Mass Index (BMI) between 18.5 and 29.9, weighing at least 110 pounds. It's not suitable for those on medications that could affect the study results, pregnant or breastfeeding women, individuals with significant health issues, smokers, or frequent alcohol users.Check my eligibility
What is being tested?
The study is examining how apple juice and cranberry juice might influence urinary tract infection (UTI) susceptibility in women by looking at their gut microbiome. The goal is to understand why cranberry juice has had mixed results in preventing UTIs.See study design
What are the potential side effects?
Since the interventions involve common beverages like apple and cranberry juice, side effects are expected to be minimal but may include mild digestive discomfort or allergic reactions in rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a healthy woman.
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I am a healthy woman.
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I weigh at least 110 pounds.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to 21 days of each intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 21 days of each intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in the unrinary anti-adhesion activity of UTI susceptible women
Secondary outcome measures
Determine the compositional differences of gut microbiome in responders and non-responders after the cranberry juice intake
Identify anti-adhesion urinary biomarkers in responders versus non-responders after the cranberry juice intake

Trial Design

2Treatment groups
Experimental Treatment
Group I: Cranberry juice consumptionExperimental Treatment1 Intervention
Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) of cranberry juice daily for 3 weeks.
Group II: Apple juice consumptionExperimental Treatment1 Intervention
Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) apple juice with matching sugar and calories daily for 3 weeks.

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor
1,341 Previous Clinical Trials
715,527 Total Patients Enrolled
United States Department of Agriculture (USDA)FED
96 Previous Clinical Trials
350,512 Total Patients Enrolled
Liwei Gu, PhDPrincipal InvestigatorUniversity of Florida
6 Previous Clinical Trials
180 Total Patients Enrolled

Media Library

Cranberry juice Clinical Trial Eligibility Overview. Trial Name: NCT05065008 — N/A
Healthy Subjects Research Study Groups: Cranberry juice consumption, Apple juice consumption
Healthy Subjects Clinical Trial 2023: Cranberry juice Highlights & Side Effects. Trial Name: NCT05065008 — N/A
Cranberry juice 2023 Treatment Timeline for Medical Study. Trial Name: NCT05065008 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this clinical experiment open to individuals aged 70 or above?

"The age requirements for enrollment in this study stipulate that participants must be older than 21 and younger than 65 years old."

Answered by AI

How many individuals have been recruited for this medical experiment?

"Affirmative. The clinical trial is currently seeking to fill 160 slots at a single site, according to the most recent data posted on clinicaltrials.gov dated January 10th 2022. This research was originally initiated October 18 2021."

Answered by AI

Are there still vacancies for participants in this experiment?

"Clinicaltrials.gov states that this research programme is actively seeking applicants, since it's initial posting on October 18th 2021 and most recent update occurring on January 10th 2022."

Answered by AI

For which groups of individuals is enrollment in this experiment authorized?

"160 individuals, aged 21-65 and with healthy subject status (hs), are required for this trial. Additionally, only female participants of 110 lbs or more who have a body mass index between 18.5 - 29.9 kg/m2 can enroll in the study."

Answered by AI

Who else is applying?

What state do they live in?
Florida
How old are they?
18 - 65
What site did they apply to?
University of Florida
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

How responsive is this trial?

Typically responds via
Email
Recent research and studies
clinicaltrials.govStudy
The Roles of Gut Microbiome in UTI Susceptible Women
2021. "The Roles of Gut Microbiome in UTI Susceptible Women". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05065008.
All > Microbiome
~53 spots leftby Aug 2025
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