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Pre- vs Post-operative SRS for Brain Cancer

Phase 3
Recruiting
Research Sponsored by AHS Cancer Control Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Previous SRS to lesions other than the one being resected is allowed
Ability to complete neurocognitive testing without assistance from family or friends
Timeline
Screening 3 weeks
Treatment Varies
Follow Up this will be assessed at 3,6,9,12,16 and 24 months.
Awards & highlights

Study Summary

This trial will compare how patients do when they have SRS before surgery versus surgery before SRS.

Who is the study for?
This trial is for adults with confirmed primary cancer who have brain metastases. They must be able to perform neurocognitive tests, not have had whole-brain radiotherapy or SRS on the lesion in question, and can't have specific cancers like germ cell tumors or small cell lung cancer.Check my eligibility
What is being tested?
The study is testing if performing stereotactic radiosurgery (SRS) before surgery gives better outcomes than doing surgery first for patients with brain metastases. It aims to see which sequence improves quality of life and reduces side effects.See study design
What are the potential side effects?
Potential side effects include tissue damage from radiation leading to headaches, nausea, hair loss at treatment site, fatigue, swelling and possible short-term worsening of neurological symptoms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had radiation therapy on cancer spots other than the one being removed.
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I can complete brain function tests on my own.
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I can make my own medical decisions or have someone who can.
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I can take care of myself and am up and about more than half of the day.
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I am 18 years old or older.
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My cancer diagnosis was confirmed through a biopsy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~this will be assessed at 3,6,9,12,16 and 24 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and this will be assessed at 3,6,9,12,16 and 24 months. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Secondary outcome measures
Controlled Oral Word Association
Distant Brain Recurrence Rate
Hopkins Verbal Learning Test
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: SRS followed by Surgical Resection (Experimental)Experimental Treatment2 Interventions
SRS followed by surgery within 1 week of radiotherapy end date.
Group II: Surgical Resection followed by SRS (Non-Experimental)Active Control2 Interventions
Surgical Resection followed by SRS within 3 weeks of surgery date.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Radiosurgery
2016
Completed Phase 2
~460

Find a Location

Who is running the clinical trial?

AHS Cancer Control AlbertaLead Sponsor
182 Previous Clinical Trials
36,124 Total Patients Enrolled

Media Library

Brain Surgery Clinical Trial Eligibility Overview. Trial Name: NCT04474925 — Phase 3
Brain Tumor Research Study Groups: Surgical Resection followed by SRS (Non-Experimental), SRS followed by Surgical Resection (Experimental)
Brain Surgery 2023 Treatment Timeline for Medical Study. Trial Name: NCT04474925 — Phase 3
Brain Tumor Clinical Trial 2023: Brain Surgery Highlights & Side Effects. Trial Name: NCT04474925 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a governing body that has accepted Brain Surgery?

"Although it is a major surgery, brain surgery has been shown to be safe in multiple clinical trials. It thus receives a score of 3."

Answered by AI

To be eligible for this experiment, what are the requirements?

"The target sample size for this study is 88 individuals aged 18-100 who have a brain tumor. In addition, these participants must have undergone SRS for lesions other than the one being resected, and their ECOG score must be 0-2."

Answered by AI

Are elderly individuals being included in this trial's pool of potential participants?

"This study is only looking for individuals that fall between 18 and 100 years of age, as specified in the inclusion criteria."

Answered by AI

How many people will be chosen to participate in this experiment?

"That is correct. The clinical trial in question, which was established on September 27th 2021 and edited September 28th, is looking for participants. In total, 88 patients will be accepted at 2 different locations."

Answered by AI

Are there any vacant slots in this clinical trial for new patients?

"The most recent information from clinicaltrials.gov suggests that this trial is actively recruiting patients. The listing was first created on September 27th, 2021 and updated the following day."

Answered by AI
~32 spots leftby Sep 2025