cTBS for Obsessive-Compulsive Disorder

Phase-Based Progress Estimates
McLean Hospital, Belmont, MAObsessive-Compulsive DisordercTBS - Device
18 - 55
All Sexes
What conditions do you have?

Study Summary

This trial will test whether a new method of transcranial magnetic stimulation can specifically help people with OCD who experience contamination/washing symptoms.

Eligible Conditions
  • Obsessive-Compulsive Disorder

Video Summary

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 6 weeks

6 weeks
Dimensional Yale-Brown Obsessive Compulsive Scale (D-YBOCS)
Functional activation of R MFG and brain regions within VAN during an RSVP task (expressed as a beta value)
Functional connectivity between R MFG and brain regions within VAN (expressed as a Z-score)
Yale-Brown Obsessive Compulsive Scale (YBOCS)

Trial Safety

Trial Design

3 Treatment Groups

1 of 3
1 of 3
1 of 3

Experimental Treatment

Non-Treatment Group

50 Total Participants · 3 Treatment Groups

Primary Treatment: cTBS · Has Placebo Group · N/A

Experimental Group · 1 Intervention: iTBS · Intervention Types: Device
Experimental Group · 1 Intervention: cTBS · Intervention Types: Device
ShamComparator Group · 1 Intervention: sham · Intervention Types: Device
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 3

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 6 weeks

Who is running the clinical trial?

Massachusetts General HospitalOTHER
2,725 Previous Clinical Trials
31,219,247 Total Patients Enrolled
26 Trials studying Obsessive-Compulsive Disorder
1,664 Patients Enrolled for Obsessive-Compulsive Disorder
Mclean HospitalLead Sponsor
195 Previous Clinical Trials
16,906 Total Patients Enrolled
7 Trials studying Obsessive-Compulsive Disorder
281 Patients Enrolled for Obsessive-Compulsive Disorder
Brian P Brennan, MDPrincipal InvestigatorMclean Hospital
3 Previous Clinical Trials
55 Total Patients Enrolled

Eligibility Criteria

Age 18 - 55 · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have been diagnosed with OCD as the main mental health issue.

Who else is applying?

What state do they live in?
What portion of applicants met pre-screening criteria?
Met criteria100.0%
How old are they?
18 - 65100.0%
What site did they apply to?
McLean Hospital100.0%

Frequently Asked Questions

What is the most populous cohort of individuals participating in this research?

"Affirmative. According to records on clinicaltrials.gov, this medical experiment – which was initialy posted on July 1st 2022 – is actively seeking out potential participants. There are 50 spots to fill at one trial site." - Anonymous Online Contributor

Unverified Answer

Are any individuals aged 20 or over permitted to join this experiment?

"In order to be considered for this medical study, the applicant must fall between 18 and 55 years old as stipulated in the eligibility requirements." - Anonymous Online Contributor

Unverified Answer

Are there any open slots remaining for this trial?

"Affirmative. Clinicaltrials.gov data shows that this clinical trial is still searching for participants as of November 14th, 2022; the study was initially published on July 1st, 2022 and requires 50 enrollees at a single site." - Anonymous Online Contributor

Unverified Answer

Can I join the research project?

"This trial seeks 50 individuals aged 18 to 55, who struggle with obsessive-compulsive disorder. Crucially, they must have CONTAM as their foremost symptom dimension (highest score on the Dimensional Yale-Brown Obsessive Compulsive Scale), not initiate a new course of exposure and response prevention therapy within 8 weeks of enrollment (continuing ERP will be allowed if begun more than 8 weeks before enrolment) and achieve at least an 8/20 on Dimension 4 of the DYBOCS." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.