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Neurostimulation for Obsessive-Compulsive Disorder(OBSESS Trial)
OBSESS Trial Summary
This trial will test whether DBS can reduce symptoms of OCD in a domain-specific manner. The investigators will use Boston Scientific Illumina software to produce imaging-derived inverse solutions to determine the similarity between intracranial electrophysiology-based solutions vs. imaging-based solutions.
- Obsessive-Compulsive Disorder
OBSESS Trial Eligibility Criteria
Inclusion CriteriaYou will be eligible if you check “Yes” for the criteria below
OBSESS Trial Timeline
Study ObjectivesOutcome measures can provide a clearer picture of what you can expect from a treatment.
Awards & Highlights
OBSESS Trial Design
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Who is running the clinical trial?
- You require diathermy treatment.You have a high risk of thinking about or attempting to harm yourself or acting without thinking.You have symptoms of depression that are caused by your OCD and have a score of at least 16 on a depression assessment.You have already tried a sufficient amount of clomipramine (a medication) and it did not work for you.You may need to have regular MRI scans during the study.You have had severe OCD (obsessive-compulsive disorder) for at least five years, and it has not responded to previous treatments. It causes a lot of distress and makes it difficult for you to live your life normally.You have tried a type of therapy called CBT for OCD, where you had at least 20 sessions with a therapist who specializes in exposure and response prevention (ERP).If you have Tourette's Disorder and your tic symptoms are as severe or impairing as your OCD symptoms, you cannot participate in the study.You have struggled with alcohol or drug addiction within the past 6 months, but nicotine use is allowed.You have been diagnosed with a long-term mental health condition called schizophrenia.
- Group 1: Medtronic Percept RC neurostimulator
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are the criteria for individuals to become eligible to participate in this trial?
"Those suffering from OCD, aged between 21 to 70 years old are eligible for this trial. A total of 12 participants are required in order for it to commence."
Is this research open to individuals that are of legal age?
"The trial is open to adults ranging from 21-70 years old; those younger or older can take part in 23 and 67 other clinical trials respectively."
Is this research study currently open to new participants?
"Indications from clinicaltrials.gov suggest that this medical research is not accepting applicants at present. While the original posting was on June 1st, 2023 and it was last updated in mid-June 2022, there are 116 alternate trials actively seeking participants as we speak."
Who else is applying?
What state do they live in?
How old are they?
What portion of applicants met pre-screening criteria?
What site did they apply to?
How many prior treatments have patients received?
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