← Back to Search

Hormone Therapy

High-dose oxytocin for Obesity in pregnancy (HILIO-PILOT Trial)

Phase 4

Waitlist Available

Research Sponsored by Ohio State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from start of induction thorough delivery

Awards & highlights

HILIO-PILOT Trial Summary

This trial will compare a high and low dose oxytocin dosing regimen for the induction of labor in women with obesity.

Eligible Conditions

Pregnant Patients With Obesity

HILIO-PILOT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 24 hours of delivery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 24 hours of delivery

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 24 hours of delivery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of Participants Delivered by Cesarean

Secondary outcome measures

Duration of Time From Start of Induction to Delivery

Duration of the First Stage of Labor

Incidence of Clinical Chorioamnionitis

+13 more

Side effects data

From 2022 Phase 4 trial • 20 Patients • NCT05289869

30%

Hospital readmission

100%

80%

60%

40%

20%

Study treatment Arm

Low-dose

High-dose

HILIO-PILOT Trial Design

2Treatment groups

Experimental Treatment

Group I: Low-dose oxytocin regimenExperimental Treatment1 Intervention

Starting dose 2 mU/min and increased by 2 mU/min every 30 minutes until adequate contractions achieved, at the discretion of the obstetric providers.

Group II: High-dose oxytocin regimenExperimental Treatment1 Intervention

Starting dose 6 mU/min and increased by 6 mU/min every 30 minutes until adequate contractions achieved, at the discretion of the obstetric providers.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Oxytocin

FDA approved

Oxytocin

FDA approved

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Ohio State UniversityLead Sponsor

830 Previous Clinical Trials

505,600 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Do I meet the criteria for this trial's enrolment?

"This medical trial seeks to enrol 20 individuals aged between 18 and 50 who have a pregnant patient with obesity. To qualify, the mother must be of legal age, in her 37th week or later of gestation, carrying a single fetus that is head-down facing downwards; there should be no contraindication for labor or vaginal delivery. The pre-pregnancy BMI has to exceed 30 kg/m2 as per self-reported figures confirmed by medical records from either before pregnancy or early trimester. Additionally, cervical dilation shouldn't surpass 4 cm upon induction initiation. Prospective applicants must also not have given birth previously and must come"

Answered by AI

Does the trial include participants within an age range younger than 45 years?

"This medical experiment is open to individuals aged 18 and over, but younger than 50 years old."

Answered by AI

Is high-dose oxytocin usage associated with any adverse effects?

"With Phase 4 trials indicating its approval, High-Dose Oxytocin scored a 3 on our team's safety assessment scale."

Answered by AI

Are volunteers still being admitted to this clinical trial?

"According to clinicaltrials.gov, the posting for this medical trial is now inactive. Posted on April 6th 2022 and last modified on September 23rd 2022, there are no longer any recruitment opportunities with this study; however, 957 other trials remain active presently."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Pilot Study: High Versus Low Oxytocin Dosing for Induction of Labor in Pregnant Patients With Obesity

Heather Frey 2022. "A Pilot Study: High Versus Low Oxytocin Dosing for Induction of Labor in Pregnant Patients With Obesity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05289869.